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1.
Front Public Health ; 11: 1256254, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38026375

RESUMO

Background: Hypothermia is common and active warming is recommended in major surgery. The potential effect on hospitals and payer costs of aggressive warming to a core temperature target of 37°C is poorly understood. Methods: In this sub-analysis of the PROTECT trial (clinicaltrials.gov, NCT03111875), we included patients who underwent radical procedures of colorectal cancer and were randomly assigned to aggressive warming or routine warming. Perioperative outcomes, operation room (OR) scheduling process, internal cost accounting data from the China Statistical yearbook (2022), and price lists of medical and health institutions in Beijing were examined. A discrete event simulation (DES) model was established to compare OR efficiency using aggressive warming or routine warming in 3 months. We report base-case net costs and sensitivity analyses of intraoperative aggressive warming compared with routine warming. Costs were calculated in 2022 using US dollars (USD). Results: Data from 309 patients were analyzed. The aggressive warming group comprised 161 patients and the routine warming group comprised 148 patients. Compared to routine warming, there were no differences in the incidence of postoperative complications and total hospitalization costs of patients with aggressive warming. The potential benefit of aggressive warming was in the reduced extubation time (7.96 ± 4.33 min vs. 10.33 ± 5.87 min, p < 0.001), lower incidence of prolonged extubation (5.6% vs. 13.9%, p = 0.017), and decreased staff costs. In the DES model, there is no add-on or cancelation of operations performed within 3 months. The net hospital costs related to aggressive warming were higher than those related to routine warming in one operation (138.11 USD vs. 72.34 USD). Aggressive warming will have an economic benefit when the OR staff cost is higher than 2.37 USD/min/person, or the cost of disposable forced-air warming (FAW) is less than 12.88 USD/piece. Conclusion: Despite improving OR efficiency, the economic benefits of aggressive warming are influenced by staff costs and the cost of FAW, which vary from different regions and countries. Clinical trial registration: clinicaltrials.gov, identifier (NCT03111875).


Assuntos
Hipotermia , Humanos , Hipotermia/etiologia , Hospitais , China
2.
Comput Math Methods Med ; 2022: 8661324, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35465016

RESUMO

Objective: To explore the application of machine learning algorithm in the prediction and evaluation of cesarean section, predicting the amount of blood transfusion during cesarean section and to analyze the risk factors of hypothermia during anesthesia recovery. Methods: (1)Through the hospital electronic medical record of medical system, a total of 600 parturients who underwent cesarean section in our hospital from June 2019 to December 2020 were included. The maternal age, admission time, diagnosis, and other case data were recorded. The routine method of cesarean section was intraspinal anesthesia, and general anesthesia was only used for patients' strong demand, taboo, or failure of intraspinal anesthesia. According to the standard of intraoperative bleeding, the patients were divided into two groups: the obvious bleeding group (MH group, N = 154) and nonobvious hemorrhage group (NMH group, N = 446). The preoperative, intraoperative, and postoperative indexes of parturients in the two groups were analyzed and compared. Then, the risk factors of intraoperative bleeding were screened by logistic regression analysis with the occurrence of obvious bleeding as the dependent variable and the factors in the univariate analysis as independent variables. In order to further predict intraoperative blood transfusion, the standard cases of recesarean section and variables with possible clinical significance were included in the prediction model. Logistic regression, XGB, and ANN3 machine learning algorithms were used to construct the prediction model of intraoperative blood transfusion. The area under ROC curve (AUROC), accuracy, recall rate, and F1 value were calculated and compared. (2) According to whether hypothermia occurred in the anesthesia recovery room, the patients were divided into two groups: the hypothermia group (N = 244) and nonhypothermia group (N = 356). The incidence of hypothermia was calculated, and the relevant clinical data were collected. On the basis of consulting the literatures, the factors probably related to hypothermia were collected and analyzed by univariate statistical analysis, and the statistically significant factors were analyzed by multifactor logistic regression analysis to screen the independent risk factors of hypothermia in anesthetic convalescent patients. Results: (1) First of all, we compared the basic data of the blood transfusion group and the nontransfusion group. The gestational age of the transfusion group was lower than that of the nontransfusion group, and the times of cesarean section and pregnancy in the transfusion group were higher than those of the non-transfusion group. Secondly, we compared the incidence of complications between the blood transfusion group and the nontransfusion group. The incidence of pregnancy complications was not significantly different between the two groups (P > 0.05). The incidence of premature rupture of membranes in the nontransfusion group was higher than that in the transfusion group (P < 0.05). There was no significant difference in the fetal umbilical cord around neck, amniotic fluid index, and fetal heart rate before operation in the blood transfusion group, but the thickness of uterine anterior wall and the levels of Hb, PT, FIB, and TT in the blood transfusion group were lower than those in the nontransfusion group, while the number of placenta previa and the levels of PLT and APTT in the blood transfusion group were higher than those in the nontransfusion group. The XGB prediction model finally got the 8 most important features, in the order of importance from high to low: preoperative Hb, operation time, anterior wall thickness of the lower segment of uterus, uterine weakness, preoperative fetal heart, placenta previa, ASA grade, and uterine contractile drugs. The higher the score, the greater the impact on the model. There was a linear correlation between the 8 features (including the correlation with the target blood transfusion). The indexes with strong correlation with blood transfusion included the placenta previa, ASA grade, operation time, uterine atony, and preoperative Hb. Placenta previa, ASA grade, operation time, and uterine atony were positively correlated with blood transfusion, while preoperative Hb was negatively correlated with blood transfusion. In order to further compare the prediction ability of the three machine learning methods, all the samples are randomly divided into two parts: the first 75% training set and the last 25% test set. Then, the three models are trained again on the training set, and at this time, the model does not come into contact with the samples in any test set. After the model training, the trained model was used to predict the test set, and the real blood transfusion status was compared with the predicted value, and the F1, accuracy, recall rate, and AUROC4 indicators were checked. In terms of training samples and test samples, the AUROC of XGB was higher than that of logistic regression, and the F1, accuracy, and recall rate of XGB of ANN were also slightly higher than those of logistic regression and ANN. Therefore, the performance of XGB algorithm is slightly better than that of logistic regression and ANN. (2) According to the univariate analysis of hypothermia during the recovery period of anesthesia, there were significant differences in ASA grade, mode of anesthesia, infusion volume, blood transfusion, and operation duration between the normal body temperature group and hypothermia group (P < 0.05). Logistic regression analysis showed that ASA grade, anesthesia mode, infusion volume, blood transfusion, and operation duration were all risk factors of hypothermia during anesthesia recovery. Conclusion: In this study, three machine learning algorithms were used to analyze the large sample of clinical data and predict the results. It was found that five important predictive variables of blood transfusion during recesarean section were preoperative Hb, expected operation time, uterine weakness, placenta previa, and ASA grade. By comparing the three algorithms, the prediction effect of XGB may be more accurate than that of logistic regression and ANN. The model can provide accurate individual prediction for patients and has good prediction performance and has a good prospect of clinical application. Secondly, through the analysis of the risk factors of hypothermia during the recovery period of cesarean section, it is found that ASA grade, mode of anesthesia, amount of infusion, blood transfusion, and operation time are all risk factors of hypothermia during the recovery period of cesarean section. In line with this, the observation of this kind of patients should be strengthened during cesarean section.


Assuntos
Anestesia , Hipotermia , Placenta Prévia , Inércia Uterina , Algoritmos , Transfusão de Sangue , Cesárea/efeitos adversos , Feminino , Humanos , Hipotermia/epidemiologia , Hipotermia/etiologia , Aprendizado de Máquina , Placenta Prévia/cirurgia , Gravidez , Estudos Retrospectivos , Fatores de Risco
3.
Am Surg ; 88(6): 1062-1070, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33375834

RESUMO

BACKGROUND: Hypothermia is an uncommon, potentially life-threatening condition. We hypothesized (1) advanced rewarming techniques were more frequent with increased hypothermia severity, (2) active rewarming is increasingly performed with smaller intravascular catheters and decreased cardiopulmonary bypass, and (3) mortality was associated with age, hypothermia severity, and type. METHODS: Trauma patients with temperatures <35°C at 4 ACS-verified trauma centers in Wisconsin and Minnesota from 2006 to 2016 were reviewed. Statistical analysis included chi-square and Fisher's exact tests. A P value < .05 was considered significant. RESULTS: 337 patients met inclusion criteria; primary hypothermia was identified in 127 (38%), secondary in 113 (34%), and mixed primary/secondary in 96 (28%) patients. Hypothermia was mild in 69%, moderate in 26%, and severe in 5% of patients. Intravascular rewarming catheter was the most frequent advanced modality (2%), used increasingly since 2014. Advanced techniques were used for primary (12%) vs. secondary (0%) and mixed (5%) (P = .0002); overall use increased with hypothermia severity but varied by institution. Dysrhythmia, acute kidney injury, and frostbite risk worsened with hypothermia severity (P < .0001, P = .031, and P < .0001, respectively). Mortality was greatest in patients with mixed hypothermia (39%, P = .0002) and age >65 years (33%, P = .03). Thirty-day mortality rates were similar among severe, moderate, and mild hypothermia (P = .44). CONCLUSION: Advanced rewarming techniques were used more frequently in severe and primary hypothermia but varied among institutions. Advanced rewarming was less common in mixed hypothermia; mortality was highest in this subgroup. Reliance on smaller intravascular catheters for advanced rewarming increased over time. Given inconsistencies in management, implementation of guidelines for hypothermia management appears necessary.


Assuntos
Injúria Renal Aguda , Hipotermia , Idoso , Catéteres , Humanos , Hipotermia/epidemiologia , Hipotermia/etiologia , Hipotermia/terapia , Minnesota/epidemiologia , Reaquecimento/métodos
4.
Injury ; 50(2): 308-317, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30409730

RESUMO

BACKGROUND: Vehicle extrication of crash victims is a highly-demanding challenge, due to the frequently life-threatening injuries of entrapped occupants. In this phase, crash victims are often exposed to the outdoor-temperature, with the risk of sustained hypothermia. Hypothermia can significantly raise the morbidity and mortality rates of crash victims. Therefore, we have correlated the incidence of severe car accidents with entrapped patients, the outdoor conditions, and expenditure of time for extrication. Furthermore, different warming strategies have been evaluated regarding their integrability within the rescue procedure. METHODS: To estimate the incidence of severe car accidents with entrapped patients, we performed retrospective data mining for the cold season of a three-year period in a rural district in Germany. We evaluated the integrability of a chemical heated blanket, its combined application with a forced-air warmer, or with an infrared radiator for patient warming. Therefore, we analysed the time tracking of extrication reference points during extrication exercises undertaken by the rescue services, simulating a severe vehicle accident and evaluated questionnaires administered to rescue personnel and subjects. Furthermore, we monitored subjects' physiologic parameters to estimate the warming effect. RESULTS: Incidence analysis resulted in extrication times of up to 80 min, representing two severely-entrapped patients per month in the cold seasons, corresponding to about four entrapments per 100.000 inhabitants every year. Of the different warming strategies analysed, the chemical blanket and the combination infrared radiator/chemical blanket were favoured regarding the items 'operator convenience', 'weight/size/handling', 'stability in positioning', 'time needed for installation', 'manpower requirement', 'hindrance during extrication operation', 'versality during extrication process', and 'robustness' by the rescue personnel; the forced-air warmer and the infrared radiator were preferred with regard to 'warming effect', the forced-air warmer and the chemical blanket was advantageous with regard to 'physical protection'. CONCLUSIONS: Vehicle extrication procedures are time consuming, a relevant finding that provides a rationale for discussing and optimising the rescue procedure to prevent sustained hypothermia. We determined that combined application of an infrared radiator and a chemical blanket is advantageous in terms of integration into the rescue process. However, a more detailed investigation, focussing on warming efficacy, must be performed.


Assuntos
Acidentes de Trânsito , Regulação da Temperatura Corporal/fisiologia , Temperatura Baixa/efeitos adversos , Exposição Ambiental/efeitos adversos , Calefação/métodos , Hipotermia/prevenção & controle , Trabalho de Resgate , Superfície Corporal , Serviços Médicos de Emergência , Alemanha , Calefação/instrumentação , Humanos , Hipotermia/etiologia , Incidência , Trabalho de Resgate/métodos , Trabalho de Resgate/organização & administração , Estudos Retrospectivos , Fatores de Tempo
5.
Artigo em Inglês | MEDLINE | ID: mdl-29601479

RESUMO

Exposure to cold weather can cause cold-related illness and death, which are preventable. To understand the current burden, risk factors, and circumstances of exposure for illness and death directly attributed to cold, we examined hospital discharge, death certificate, and medical examiner data during the cold season from 2005 to 2014 in New York City (NYC), the largest city in the United States. On average each year, there were 180 treat-and-release emergency department visits (average annual rate of 21.6 per million) and 240 hospital admissions (29.6 per million) for cold-related illness, and 15 cold-related deaths (1.8 per million). Seventy-five percent of decedents were exposed outdoors. About half of those exposed outdoors were homeless or suspected to be homeless. Of the 25% of decedents exposed indoors, none had home heat and nearly all were living in single-family or row homes. The majority of deaths and illnesses occurred outside of periods of extreme cold. Unsheltered homeless individuals, people who use substances and become incapacitated outdoors, and older adults with medical and psychiatric conditions without home heat are most at risk. This information can inform public health prevention strategies and interventions.


Assuntos
Temperatura Baixa/efeitos adversos , Efeitos Psicossociais da Doença , Hipotermia/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Pessoas Mal Alojadas , Humanos , Hipotermia/etiologia , Lactente , Recém-Nascido , Masculino , Transtornos Mentais/complicações , Pessoa de Meia-Idade , Cidade de Nova Iorque/epidemiologia , Fatores de Risco , Estações do Ano , Adulto Jovem
6.
J Infect Chemother ; 23(11): 757-762, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28847586

RESUMO

Quick sequential organ failure assessment (qSOFA) was proposed in the new sepsis definition (Sepsis-3). Although qSOFA was created to identify patients with suspected infection and likely to have poor outcomes, the clinical utility of qSOFA to screen sepsis has not been fully evaluated. We investigated the number of patients diagnosed as having severe sepsis who could not be identified by the qSOFA criteria and what clinical signs could complement the qSOFA score. This retrospective analysis of a multicenter prospective registry included adult patients with severe sepsis diagnosed outside the intensive care unit (ICU) by conventional criteria proposed in 2003. We conducted receiver operating characteristic (ROC) analyses to assess the predictive value for in-hospital mortality and compared clinical characteristics between survivors and non-survivors with qSOFA score ≤ 1 point (qSOFA-negative). Among 387 eligible patients, 63 (16.3%) patients were categorized as qSOFA-negative, and 10 (15.9%) of these patients died. The area under the ROC curve for the qSOFA score was 0.615, which was superior to that for the systemic inflammatory response syndrome score (0.531, P = 0.019) but inferior to that for the SOFA score (0.702, P = 0.005). Multivariate logistic regression analysis showed that hypothermia might be associated with poor outcome independently of qSOFA criteria. Our findings suggested that qSOFA had a suboptimal level of predictive value outside the ICU and could not identify 16.3% of patients who were once actually diagnosed with sepsis. Hypothermia might be associated with an increased risk of death that cannot be identified by qSOFA.


Assuntos
Mortalidade Hospitalar , Hipotermia/mortalidade , Escores de Disfunção Orgânica , Sistema de Registros/estatística & dados numéricos , Sepse/mortalidade , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Hipotermia/etiologia , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Prognóstico , Estudos Prospectivos , Curva ROC , Estudos Retrospectivos , Sepse/complicações , Sobreviventes/estatística & dados numéricos
7.
Scand J Trauma Resusc Emerg Med ; 25(1): 43, 2017 Apr 24.
Artigo em Inglês | MEDLINE | ID: mdl-28438222

RESUMO

BACKGROUND: Hypothermia is common in trauma victims and is associated with increased mortality, however its causes are little known. The objective of this study was to identify the risk factors associated with hypothermia in prehospital management of trauma victims. METHODS: This was an ancillary analysis of data recorded in the HypoTraum study, a prospective multicenter study conducted by the emergency medical services (EMS) of 8 hospitals in France. Inclusion criteria were: trauma victim, age over 18 years, and victim receiving prehospital care from an EMS team and transported to hospital by the EMS team in a medically equipped mobile intensive care unit. The following data were recorded: victim demographics, circumstances of the trauma, environmental factors, patient presentation, clinical data and time from accident to EMS arrival. Independent risk factors for hypothermia were analyzed in a multivariate logistic regression model. RESULTS: A total of 461 trauma patients were included in the study. Road traffic accidents (N = 261; 57%) and falls (N = 65; 14%) were the main causes of trauma. Hypothermia (<35 °C) was present in 136/461 cases (29%). Independent factors significantly associated with the presence of hypothermia were: a low GCS (Odds Ratio (OR) = 0,87 ([0,81-0,92]; p < 0.0001), a low air temperature (OR = 0,93 [0,91-0,96]; p < 0.0001) and a wet patient (OR = 2,08 [1,08-4,00]; p = 0.03). CONCLUSION: The incidence of hypothermia was high on EMS arrival at the scene. Body temperature measurement and immediate thermal protection should be routine, and special attention should be given to patients who are wet. LEVEL OF EVIDENCE: Prospective, multicenter, open, observational study; Level IV.


Assuntos
Serviços Médicos de Emergência , Hipotermia/epidemiologia , Ferimentos e Lesões/epidemiologia , Adulto , Ambulâncias , Feminino , França/epidemiologia , Humanos , Hipotermia/etiologia , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Fatores de Risco , Ferimentos e Lesões/complicações
8.
Crit Care ; 20(1): 107, 2016 Apr 20.
Artigo em Inglês | MEDLINE | ID: mdl-27095272

RESUMO

Hypothermia is present in up to two-thirds of patients with severe injury, although it is often disregarded during the initial resuscitation. Studies have revealed that hypothermia is associated with mortality in a large percentage of trauma cases when the patient's temperature is below 32 °C. Risk factors include the severity of injury, wet clothing, low transport unit temperature, use of anesthesia, and prolonged surgery. Fortunately, associated coagulation disorders have been shown to completely resolve with aggressive warming. Selected passive and active warming techniques can be applied in damage control resuscitation. While treatment guidelines exist for acidosis and bleeding, there is no evidence-based approach to managing hypothermia in trauma patients. We synthesized a goal-directed algorithm for warming the severely injured patient that can be directly incorporated into current Advanced Trauma Life Support guidelines. This involves the early use of warming blankets and removal of wet clothing in the prehospital phase followed by aggressive rewarming on arrival at the hospital if the patient's injuries require damage control therapy. Future research in hypothermia management should concentrate on applying this treatment algorithm and should evaluate its influence on patient outcomes. This treatment strategy may help to reduce blood loss and improve morbidity and mortality in this population of patients.


Assuntos
Hipotermia/etiologia , Reação Transfusional , Ferimentos e Lesões/complicações , Transfusão de Sangue/mortalidade , Gerenciamento Clínico , Humanos , Hipotermia/mortalidade , Ressuscitação/efeitos adversos , Reaquecimento/métodos , Ferimentos e Lesões/mortalidade , Ferimentos e Lesões/fisiopatologia
9.
Int Surg ; 100(1): 105-8, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25594647

RESUMO

Perioperative temperature management is imperative for positive surgical outcomes. This study assessed the clinical and wellbeing benefits of extending normothermia by using a portable warming gown. A total of 94 patients undergoing elective surgery were enrolled. They were randomized pre-operatively to either a portable warming gown or the standard warming procedure. The warming gown stayed with patients from pre-op to operating room to postrecovery room discharge. Core temperature was tracked throughout the study. Patients also provided responses to a satisfaction and comfort status survey. The change in average core temperature did not differ significantly between groups (P = 0.23). A nonsignificant 48% relative decrease in hypothermic events was observed for the extended warming group (P = 0.12). Patients receiving the warming gown were more likely to report always having their temperature controlled (P = 0.04) and significantly less likely to request additional blankets for comfort (P = 0.006). Clinical outcomes and satisfaction were improved for patients with extended warming.


Assuntos
Procedimentos Cirúrgicos Eletivos , Temperatura Alta/uso terapêutico , Hipotermia/prevenção & controle , Complicações Intraoperatórias/prevenção & controle , Assistência Perioperatória/métodos , Complicações Pós-Operatórias/prevenção & controle , Roupa de Proteção , Adulto , Idoso , Temperatura Corporal , Feminino , Custos Hospitalares/estatística & dados numéricos , Humanos , Hipotermia/diagnóstico , Hipotermia/economia , Hipotermia/epidemiologia , Hipotermia/etiologia , Complicações Intraoperatórias/diagnóstico , Complicações Intraoperatórias/economia , Complicações Intraoperatórias/epidemiologia , Masculino , Michigan , Pessoa de Meia-Idade , Satisfação do Paciente , Assistência Perioperatória/economia , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/economia , Complicações Pós-Operatórias/epidemiologia , Roupa de Proteção/economia , Resultado do Tratamento
10.
Injury ; 40 Suppl 4: S47-52, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19895952

RESUMO

Damage control orthopaedics (DCO) is a staged approach for the management of multiply injured patients. It is ideal for trauma patients presenting in an unstable or extremis physiological state. It focuses on the rapid resuscitation of these patients by providing temporary stabilisation of fractures while at the same time reducing the biological load of surgery. Early findings support its usefulness in controlling the lethal triad of hypothermia, acidosis and coagulopathy. Furthermore, recent evidence indicates that it regulates the evolving systemic inflammatory response, reducing the detrimental complications of adult respiratory distress syndrome, multiple organ dysfunction and subsequent mortality. Although DCO has been proven a useful surgical strategy for efficiently managing patients with multiple trauma, further work is required to establish fully its indications, results and cost implications.


Assuntos
Traumatismo Múltiplo/terapia , Procedimentos Ortopédicos/métodos , Ressuscitação/métodos , Acidose/etiologia , Acidose/prevenção & controle , Transtornos da Coagulação Sanguínea/etiologia , Transtornos da Coagulação Sanguínea/terapia , Protocolos Clínicos , Fraturas Ósseas/cirurgia , Humanos , Hipotermia/etiologia , Escala de Gravidade do Ferimento , Tempo de Internação , Insuficiência de Múltiplos Órgãos/etiologia , Insuficiência de Múltiplos Órgãos/prevenção & controle , Traumatismo Múltiplo/complicações , Seleção de Pacientes , Síndrome do Desconforto Respiratório/etiologia , Síndrome do Desconforto Respiratório/prevenção & controle , Gestão de Riscos , Resultado do Tratamento
12.
Ind Health ; 47(3): 235-41, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19531909

RESUMO

Protection of humans working in open areas during a cold period is of great importance. Cold influences human heat state, health and functional capacity. The assessment criteria for optimal permissible heat state during work time and maximum permissible heat state demanding regulation of cold exposure time are described. They form the basis for estimation and forecast of cold risk. Classification of cooling risk is made on the basis of factors such as mean skin temperature, heat deficit, strain of thermo regulative reactions, thermal sensation, and occupational conditions. Cooling risk is also dependent on human factors such as metabolic rate and clothing thermal insulation and ambient conditions such as air temperature, wind velocity, and exposure time. For evaluation of the cooling risk a regression equation is presented for determination of the integral index of cooling conditions (IICC). On basis of the IICC value, presented in a nomogram it is possible to predict the probability of cooling risk of various rates. In consideration of the shifting climate conditions of Russia, requirements for thermal insulation of protective clothing for four major climate regions of the country are presented.


Assuntos
Temperatura Baixa/efeitos adversos , Hipotermia/etiologia , Previsões , Humanos , Hipotermia/metabolismo , Hipotermia/prevenção & controle , Análise de Regressão , Medição de Risco/métodos , Medição de Risco/estatística & dados numéricos , Federação Russa
13.
Crit Care Med ; 37(7 Suppl): S265-72, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19535957

RESUMO

Exsanguinating hemorrhage is a common clinical feature of multisystem trauma that results in death or severe disability. Cardiovascular collapse resulting from hemorrhage is unresponsive to conventional methods of cardiopulmonary resuscitation. Even when bleeding is controlled rapidly, adequate circulation cannot be restored in time to avoid neurologic consequences that appear after only 5 mins of cerebral ischemia and hypoperfusion. Reperfusion adds further insult to injury. A novel solution to this problem would be to institute a therapy that makes cells and organs more resistant to ischemic injury, thereby extending the time they can tolerate such an insult. Hypothermia can attenuate some effects of ischemia and reperfusion. Accumulating preclinical data demonstrate that hypothermia can be induced safely and rapidly to achieve emergency preservation for resuscitation during lethal hemorrhage. Hypothermia may be an effective therapeutic approach for otherwise lethal traumatic hemorrhage, and a clinical trial to determine its utility is warranted.


Assuntos
Cuidados Críticos/métodos , Hipotermia Induzida/métodos , Traumatismo Múltiplo/terapia , Animais , Reanimação Cardiopulmonar/métodos , Causas de Morte , Efeitos Psicossociais da Doença , Cuidados Críticos/tendências , Modelos Animais de Doenças , Estudos de Viabilidade , Previsões , Humanos , Hipotermia/etiologia , Hipotermia Induzida/tendências , Estudos Multicêntricos como Assunto , Traumatismo Múltiplo/complicações , Traumatismo Múltiplo/epidemiologia , Seleção de Pacientes , Traumatismo por Reperfusão/etiologia , Traumatismo por Reperfusão/prevenção & controle , Choque Hemorrágico/etiologia , Resultado do Tratamento , Estados Unidos/epidemiologia
14.
Crit Care Med ; 36(7 Suppl): S304-10, 2008 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-18594257

RESUMO

BACKGROUND: Although the use of damage control surgery for blunt and penetrating injury has been widely reported and defined, the use of damage control surgery on the battlefield (combat damage control surgery) has not been well detailed. DISCUSSION: Damage control surgery is now well established as the standard of care for severely injured civilian patients requiring emergent laparotomy in the United States. The civilian damage control paradigm is based on a "damage control trilogy." This trilogy comprises an abbreviated operation, intensive care unit resuscitation, and a return to the operating room for the definitive operation. The goal of damage control surgery and the triology is avoidance of irreversible physiological insult termed the lethal triad. The lethal triad comprises the vicious cycle of hypothermia, acidosis, and coagulopathy. Although the damage control model involves the damage control trilogy, abbreviated operation, intensive care unit resuscitation, and definitive operation, all in the same surgical facility, the combat damage control paradigm must incorporate global evacuation through several military surgical facilities and involves up to ten stages to allow for battlefield evacuation, surgical operations, multiple resuscitations, and transcontinental transport. SUMMARY: Combat damage control surgery represents many unique challenges for those who care for the severely injured patients in a combat zone.


Assuntos
Cuidados Críticos/organização & administração , Medicina Militar/organização & administração , Traumatologia/organização & administração , Ferimentos e Lesões/cirurgia , Acidose/etiologia , Transtornos da Coagulação Sanguínea/etiologia , Necessidades e Demandas de Serviços de Saúde , Hemorragia/etiologia , Humanos , Hipotermia/etiologia , Guerra do Iraque 2003-2011 , Modelos Organizacionais , Objetivos Organizacionais , Assistência Perioperatória/organização & administração , Reoperação , Ressuscitação/métodos , Transporte de Pacientes/organização & administração , Estados Unidos , Ferimentos e Lesões/complicações , Ferimentos e Lesões/mortalidade
15.
Best Pract Res Clin Anaesthesiol ; 22(4): 645-57, 2008 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19137808

RESUMO

Perioperative hypothermia is a common and serious complication of anesthesia and surgery and is associated with many adverse perioperative outcomes. It prolongs the duration of action of inhaled and intravenous anesthetics as well as the duration of action of neuromuscular drugs. Mild core hypothermia increases thermal discomfort, and is associated with delayed post anaesthetic recovery. Mild hypothermia significantly increases perioperative blood loss and augments allogeneic transfusion requirement. Only 1.9 degrees C core hypothermia triples the incidence of surgical wound infection following colon resection and increases the duration of hospitalization by 20%. Hypothermia adversely affects antibody- and cell-mediated immune defences, as well as the oxygen availability in the peripheral wound tissues. Furthermore mild hypothermia triples the incidence of postoperative adverse myocardial events. Thus, even mild hypothermia contributes significantly to patient care costs and needs to be avoided.


Assuntos
Hipotermia/fisiopatologia , Assistência Perioperatória/métodos , Complicações Pós-Operatórias/fisiopatologia , Anestesia Geral/efeitos adversos , Animais , Regulação da Temperatura Corporal/fisiologia , Humanos , Hipotermia/etiologia , Hipotermia/prevenção & controle , Assistência Perioperatória/economia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Estremecimento/fisiologia , Procedimentos Cirúrgicos Operatórios/efeitos adversos
16.
J Am Coll Nutr ; 26(5): 412-5, 2007 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-17914128

RESUMO

OBJECTIVE: Hypothermia is a known symptom of neonatal polycythemia (NP) and its pathophysiology is unclear. The effect of partial dilutional exchange transfusion (PET) upon resting energy expenditure (REE) is unknown. We aimed to test the hypothesis that PET leads to an increase in REE. STUDY DESIGN: 11 patients with NP who underwent PET and 10 controls without polycythemia were studied. NP was defined as a venous HCT >/=0.65. Per protocol, symptomatic infants and/or those with venous HCT > or =0.70 underwent PET. REE was measured just prior and 23 hours after PET in patients with NP and at identical ages in the control group. Infants were studied in a skin servo controlled radiant warmer, while clinically and thermally stable, prone and asleep. Measurements were stopped during body movements (less than 5% of the time of measurement). Metabolic measurements were performed by indirect calorimetry, using the Deltatrac II Metabolic monitor (Datex-Ohmeda, Helsinki, Finland). This instrument uses the principle of the open circuit system that allows continuous measurements of oxygen consumption (Vo(2)) and carbon dioxide production (Vco(2)) using a constant flow generator. REE measurements were corrected for the infant weight (Kcal/kg/d). Comparison of REE values between groups was performed using paired Wilcoxon ranked test. RESULTS: Patients with and without NP had nearly identical baseline REE. In patients with NP, REE increased from 44.0 +/- 6.6 Kcal/Kg/d to 48.3 +/- 5.1 Kcal/Kg/d after PET (P<0.05). Furthermore, the increase in REE following PET correlated inversely with the decrease in hematocrit. There was no significant change in REE over time in the control group. In the NP group, symptomatic infants (n=5) had a significantly greater increase in REE following PET than non-symptomatic ones (1.4 +/- 6.3 vs. 7.8 +/- 4.9 Kcal/Kg/d, p<0.05). CONCLUSIONS: Energy expenditure of polycythemic infants increases following PET, in a manner proportional to the decrease in hematocrit. Symptomatic polycythemic infants have a greater rise in REE following PET than non-symptomatic ones. We speculate that polycythemia leads to a decreased REE that might be remedied by PET.


Assuntos
Metabolismo Basal/fisiologia , Transfusão Total/métodos , Hipotermia/terapia , Policitemia/fisiopatologia , Policitemia/terapia , Calorimetria Indireta , Estudos de Casos e Controles , Metabolismo Energético/fisiologia , Feminino , Hematócrito , Humanos , Hipotermia/etiologia , Recém-Nascido , Masculino , Estatísticas não Paramétricas
17.
Br J Community Nurs ; 12(1): 23-6, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17353808

RESUMO

Excess winter mortality of some thousands of deaths of older people has occurred in the UK for the past 150 years and shows only moderate abatement. Government policies in both health and social care have had little apparent effect, other than a slow decline in seasonality due largely to secular trends. There are a number of apparent misconceptions, commonly held in the public mind and subsumed in public policy, which need to be corrected in order to reduce the toll of winter cold on older people. The evidence shows that winter deaths are to a large extent avoidable. They are not due to hypothermia as is widely believed, may not be necessarily reduced by climate change in the foreseeable future and may only be partially reduced by improving indoor warmth alone. The key is an integrated policy which reduces all risks equally. Community nursing is well placed to play a pivotal role in such policies.


Assuntos
Temperatura Baixa/efeitos adversos , Hipotermia/mortalidade , Infarto do Miocárdio/mortalidade , Doenças Respiratórias/mortalidade , Estações do Ano , Acidente Vascular Cerebral/mortalidade , Idoso , Atitude Frente a Saúde , Causas de Morte , Clima , Enfermagem em Saúde Comunitária/organização & administração , Planejamento em Saúde Comunitária , Monitoramento Ambiental , Monitoramento Epidemiológico , Europa (Continente) , Política de Saúde , Necessidades e Demandas de Serviços de Saúde , Serviços de Saúde para Idosos , Calefação , Humanos , Hipotermia/etiologia , Hipotermia/prevenção & controle , Infarto do Miocárdio/etiologia , Infarto do Miocárdio/prevenção & controle , Papel do Profissional de Enfermagem , Opinião Pública , Doenças Respiratórias/etiologia , Doenças Respiratórias/prevenção & controle , Fatores de Risco , Medicina Estatal , Acidente Vascular Cerebral/etiologia , Acidente Vascular Cerebral/prevenção & controle , Reino Unido/epidemiologia
18.
Disaster Manag Response ; 5(1): 8-13, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17306748

RESUMO

OBJECTIVE: To identify the health needs of patients with chronic diseases who lived through the great Hanshin earthquake of 1995. METHODS: Twenty-nine patients with rheumatism, diabetes, or chronic respiratory disease were enrolled in the study. Semi-structured interviews were performed by the authors in 2004. RESULTS: Priorities for patients with all three diseases were securing medications and ensuring that they were able to take their medications. Rheumatism patients required methods of preventing their bodies from becoming cold, fatigued, and stressed in order to prevent aggravation of their disease; they also wanted relief workers to understand the physical limitations they experience. The health needs of diabetic patients included receiving an appropriate diet and developing ways to cope with the stress caused by the change in living environment. Patients with chronic respiratory diseases reported that their health needs included developing methods to prevent their bodies from becoming cold, fatigued, and stressed in order to prevent aggravation of their disease, access to respiratory masks to minimize dust and cold air exposure, and guidance in methods to alleviate respiratory symptoms. CONCLUSIONS: The emergency preparedness planning and care priorities for individuals with chronic health problems, such as rheumatism, diabetes, and pulmonary disease, should include attention to medication availability, stress management, support for activities of daily living, appropriate food, and availability of support devices necessary to minimize exacerbation of symptoms.


Assuntos
Atitude Frente a Saúde , Diabetes Mellitus/psicologia , Planejamento em Desastres/organização & administração , Desastres , Avaliação das Necessidades/organização & administração , Doença Pulmonar Obstrutiva Crônica/psicologia , Doenças Reumáticas/psicologia , Atividades Cotidianas , Adaptação Psicológica , Idoso , Doença Crônica , Fadiga/etiologia , Fadiga/prevenção & controle , Feminino , Abastecimento de Alimentos , Prioridades em Saúde , Acessibilidade aos Serviços de Saúde , Humanos , Hipotermia/etiologia , Hipotermia/prevenção & controle , Japão , Masculino , Pessoa de Meia-Idade , Pesquisa Metodológica em Enfermagem , Socorro em Desastres/organização & administração , Estresse Psicológico/etiologia , Estresse Psicológico/prevenção & controle , Inquéritos e Questionários
19.
Surg Technol Int ; 15: 19-22, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-17029156

RESUMO

Forced-air warming is known as an effective procedure in prevention and treatment of perioperative hypothermia. Hypothermia is associated with disturbances of coagulation, raises postoperative oxygen consumption by shivering, increases cardiac morbidity, leads to a higher incidence of wound infection, and prolongs hospital stay. Additionally, preoperative local warming reduces the incidence of wound infection after clean surgery. In an animal experiment it has been demonstrated that even during large abdominal operations the major source of heat loss was the skin. Although evaporation accounted for the largest heat loss from the abdominal cavity, it was a minor source due to the smaller heat losing area. As a consequence, reduction of heat loss from the skin is the most promising approach to avoid hypothermia. During abdominal surgery and lower-limb surgery, the use of upper blankets is favourable. The use of upper-body blankets implies a reduction of heat loss in a relevant area and, furthermore, a heat gain. The covered area is approximately 0.35 m2, or approximately 15%-20% of body surface. The heat balance in this area can be changed by 46.1W to 55.0W by forced-air warming systems with upper body blankets. Depending on the surgical procedure and resulting fluid demand, forced-air warming with upper-body blankets-in combination with insulation and fluid warming-is an effective method to prevent perioperative hypothermia.


Assuntos
Calefação/instrumentação , Hipotermia/etiologia , Hipotermia/prevenção & controle , Assistência Perioperatória/instrumentação , Complicações Pós-Operatórias/prevenção & controle , Reaquecimento/instrumentação , Procedimentos Cirúrgicos Operatórios/efeitos adversos , Movimentos do Ar , Animais , Convecção , Desenho de Equipamento , Calefação/métodos , Humanos , Assistência Perioperatória/métodos , Reaquecimento/métodos , Avaliação da Tecnologia Biomédica
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