Economic benefit analysis of lithium battery recycling based on machine learning algorithm.

Lithium batteries, as an important energy storage device, are widely used in the fields of renewable vehicles and renewable energy. The related lithium battery recycling industry has also ushered in a golden period of development. However, the high cost of lithium battery recycling makes it difficult to accurately evaluate its recycling value, which seriously restricts the development of the industry. To address the above issues, machine learning will be applied in the field of economic benefit analysis for lithium battery recycling, and backpropagation neural networks will be combined with stepwise regression. On the basis of considering social and commercial values, a lithium battery recycling and utilization economic benefit analysis model based on stepwise regression backpropagation neural network was designed. The experimental results show that the mean square error of the model converges between 10-6 and 10-7, and the convergence speed is improved by 33%. In addition, in practical experiments, the model predicted the actual economic benefits of recycling a batch of lithium batteries. The results show that the predictions are basically in line with the true values. Therefore, the economic benefit analysis and prediction model for lithium battery recycling proposed in the study has the advantages of high accuracy and fast operation speed, providing new ideas and tools for promoting innovation in the field of economic benefit analysis. It has certain application potential in the evaluation of the benefits of lithium battery recycling.

Review of lithium-ion batteries' supply-chain in Europe: Material flow analysis and environmental assessment.

European legislation stated that electric vehicles' sale must increase to 35% of circulating vehicles by 2030, and concern is associated to the batteries' supply chain. This review aims at analysing the impacts (about material flows and CO2 eq emissions) of Lithium-Ion Batteries' (LIBs) recycling at full-scale in Europe in 2030 on the European LIBs' supply-chain. Literature review provided the recycling technologies' (e.g., pyro- and hydrometallurgy) efficiencies, and an inventory of existing LIBs' production and recycling plants in Europe. European production plants exhibit production capacity adequate for the expected 2030 needs. The key critical issues associated to recycling regard pre-treatments and the high costs and environmental impacts of metallurgical processes. Then, according to different LIBs' composition and market shares in 2020, and assuming a 10-year battery lifetime, the Material Flow Analysis (MFA) of the metals embodied in End of Life (EoL) LIBs forecasted in Europe in 2030 was modelled, and the related CO2 eq emissions calculated. In 2030 the European LIBs' recycling structure is expected to receive 664 t of Al, 530 t of Co, 1308 t of Cu, 219 t of Fe, 175 t of Li, 287 t of Mn and 486 t of Ni. Of these, 99% Al, 86% Co, 96% Cu, 88% Mn and 98% Ni will be potentially recovered by pyrometallurgy, and 71% Al, 92% Co, 92% Fe, 96% Li, 88 % Mn and 90% Ni by hydrometallurgy. However, even if the recycling efficiencies of the technologies applied at full-scale are high, the treatment capacity of European recycling plants could supply as recycled metals only 2%-wt of the materials required for European LIBs' production in 2030 (specifically 278 t of Al, 468 t of Co, 531 t of Cu, 114 t of Fe, 95 t of Li, 250 t of Mn and 428 t of Ni). Nevertheless, including recycled metals in the production of new LIBs could cut up 28% of CO2 eq emissions, compared to the use of virgin raw materials, and support the European batteries' value chain.

A study on the treatment of brain tumors with BNCT using several moderators with different thicknesses.

Boron neutron capture therapy (BNCT) is an effective binary radiation therapy that depends on nuclear capture reactions. In recent years, BNCT can be performed without a reactor owing to the development of accelerator-based neutron sources. A new BNCT irradiation facility is proposed, which is based on a 15 mA 2.5 MeV proton accelerator with a 100 µm thickness natural lithium target as a neutron converter. A great quantity of studies has shown that neutron beams with different spectra have unique therapeutic effects on tumors. An appropriate neutron beam for BNCT is obtained by Beam Shaping Assembly (BSA) and the moderator plays a main role in determining the BSA outlet beam spectrum. To figure out the dose distribution in phantom with various kinds of neutron spectrum modes during BNCT, a series of cases are calculated by MCNPX code. The results give a database for treatment of brain tumors with BNCT by using different moderators.

Risk assessment and strontium isotopic tracing of potentially toxic metals in creek sediments around a uranium mine, China.

The contamination of creek sediments near industrially nuclear dominated site presents significant environmental challenges, particularly in identifying and quantifying potentially toxic metal (loid)s (PTMs). This study aims to measure the extent of contamination and apportion related sources for nine PTMs in alpine creek sediments near a typical uranium tailing dam from China, including strontium (Sr), rubidium (Rb), manganese (Mn), lithium (Li), nickel (Ni), copper (Cu), vanadium (V), cadmium (Cd), zinc (Zn), using multivariate statistical approach and Sr isotopic compositions. The results show varying degrees of contamination in the sediments for some PTMs, i.e., Sr (16.1-39.6 mg/kg), Rb (171-675 mg/kg), Mn (224-2520 mg/kg), Li (11.6-78.8 mg/kg), Cd (0.31-1.38 mg/kg), and Zn (37.1-176 mg/kg). Multivariate statistical analyses indicate that Sr, Rb, Li, and Mn originated from the uranium tailing dam, while Cd and Zn were associated with abandoned agricultural activities, and Ni, Cu, and V were primarily linked to natural bedrock weathering. The Sr isotope fingerprint technique further suggests that 48.22-73.84% of Sr and associated PTMs in the sediments potentially derived from the uranium tailing dam. The combined use of multivariate statistical analysis and Sr isotopic fingerprint technique in alpine creek sediments enables more reliable insights into PTMs-induced pollution scenarios. The findings also offer unique perspectives for understanding and managing aqueous environments impacted by nuclear activities.

Resource recovery and regeneration strategies for spent lithium-ion batteries: Toward sustainable high-value cathode materials.

Traditional cathode recycling methods have become outdated amid growing concerns for high-value output and environmental friendliness in spent Li-ion battery (LIB) recycling. Our study presents a closed-loop approach that involves selective sulfurization roasting, water leaching, and regeneration, efficiently transforming spent ternary Li batteries (i.e., NCM) into high-performance cathode materials. By combining experimental investigations with density functional theory (DFT) calculations, we elucidate the mechanisms within the NCM-C-S roasting system, providing a theoretical foundation for selective sulfidation. Utilizing in situ X-ray diffraction techniques and a series of consecutive experiments, the study meticulously tracks the evolution of regenerating cathode materials that use transition metal sulfides as their primary raw materials. The Li-rich regenerated NCM exhibits exceptional electrochemical performance, including long-term cycling, high-rate capabilities, reversibility, and stability. The closed-loop approach highlights the sustainability and environmental friendliness of this recycling process, with potential applications in other cathode materials, such as LiCoO2 and LiMn2O4. Compared with traditional methods, this short process approach avoids the complexity of leaching, solvent extraction, and reverse extraction, significantly increasing metal utilization and Li recovery rates while reducing pollution and resource waste.

Assessment of a one-week ketogenic diet on brain glycolytic metabolism and on the status epilepticus stage of a lithium-pilocarpine rat model.

The ketogenic diet (KD) has been shown to be effective in refractory epilepsy after long-term administration. However, its interference with short-term brain metabolism and its involvement in the early process leading to epilepsy remain poorly understood. This study aimed to assess the effect of a short-term ketogenic diet on cerebral glucose metabolic changes, before and after status epilepticus (SE) in rats, by using [18F]-FDG PET. Thirty-nine rats were subjected to a one-week KD (KD-rats, n = 24) or to a standard diet (SD-rats, n = 15) before the induction of a status epilepticus (SE) by lithium-pilocarpine administrations. Brain [18F]-FDG PET scans were performed before and 4 h after this induction. Morphological MRIs were acquired and used to spatially normalize the PET images which were then analyzed voxel-wisely using a statistical parametric-based method. Twenty-six rats were analyzed (KD-rats, n = 15; SD-rats, n = 11). The 7 days of the KD were associated with significant increases in the plasma ß-hydroxybutyrate level, but with an unchanged glycemia. The PET images, recorded after the KD and before SE induction, showed an increased metabolism within sites involved in the appetitive behaviors: hypothalamic areas and periaqueductal gray, whereas no area of decreased metabolism was observed. At the 4th hour following the SE induction, large metabolism increases were observed in the KD- and SD-rats in areas known to be involved in the epileptogenesis process late-i.e., the hippocampus, parahippocampic, thalamic and hypothalamic areas, the periaqueductal gray, and the limbic structures (and in the motor cortex for the KD-rats only). However, no statistically significant difference was observed when comparing SD and KD groups at the 4th hour following the SE induction. A one-week ketogenic diet does not prevent the status epilepticus (SE) and associated metabolic brain abnormalities in the lithium-pilocarpine rat model. Further explorations are needed to determine whether a significant prevention could be achieved by more prolonged ketogenic diets and by testing this diet in less severe experimental models, and moreover, to analyze the diet effects on the later and chronic stages leading to epileptogenesis.

Life cycle assessment of secondary use and physical recycling of lithium-ion batteries retired from electric vehicles in China.

With the rapid development of the global new energy vehicle industry, how to minimize the environmental impact of the recovery has become a common concern and urgent concern. China is a major production and consumption market for electric vehicles, there are no specific and extensive resource and environmental assessment system for batteries. In this paper, the retired Electric vehicles lithium-ion batteries (LIBs) was the research object, and a specific analysis of the recycling treatment and gradual use stages of power batteries were based on life cycle assessment. Different battery assessment scenarios were established according to the development of battery recycling in China. The results showed that the secondary use has the optimal performance compared to the full-component physical, pyrometallurgical and hydrometallurgy recycling. The results showed that direct recycling has a GWP of 0.037 kg-CO2 eq·kg LIB-1, which is lower than others. Secondary use of LIB accounts for the most emission reductions with Global warming (GWP) as 12.134 kg-CO2 eq·kg LIB-1. The secondary use has the greatest impact on the assessment results, especially in dynamic scenarios. Through a comprehensive comparison of different recycling technologies, the secondary use, increasing the recycling rate, reducing resource, energy consumption and pollution emissions.

Circular economy strategies for mitigating metals shortages in electric vehicle batteries under China's carbon-neutral target.

Concerns over supply risks of critical metals used in electric vehicle (EV) batteries are frequently underscored as impediments to the widespread development of EVs. With the progress to achieve carbon neutrality by 2060 for China, projecting the critical metals demand for EV batteries and formulating strategies, especially circular economy strategies, to mitigate the risks of demand-supply imbalance in response to potential obstacles are necessary. However, the development scale of EVs in the transport sector to achieve China's carbon neutrality is unclear, and it remains uncertain to what extent circular economy strategies might contribute to the reduction of primary raw materials extraction. Consequently, we explore the future quantity of EVs in China required to achieve carbon neutrality and quantify the primary supply security levels of critical metals with the effort of battery cascade utilization, technology substitutions, recycling efficiency improvement, and novel business models, by integrating dynamic material flow analysis and national energy technology model. This study reveals that although 18%-30% of lithium and 20%-41% of cobalt, nickel, and manganese can be supplied to EVs through the reuse and recycling of end-of-life batteries, sustainable circular economy strategies alone are insufficient to obviate critical metals shortages for China's EV development. However, the supplementary capacity offered by second-life EV batteries, which refers to the use of batteries after they have reached the end of their first intended life, may prove adequate for China's prospective novel energy storage applications. The cumulative primary demand for lithium, cobalt, and nickel from 2021 to 2060 would reach 5-7 times, 23-114 times, and 4-19 times the corresponding mineral reserves in China. Substantial reduction of metals supply risks apart from lithium can be achieved by the cobalt-free battery technology developments combined with efficient recycling systems, where secondary supply can satisfy the demand as early as 2054.

A review on the recycling of spent lithium iron phosphate batteries.

Lithium iron phosphate (LFP) batteries have gained widespread recognition for their exceptional thermal stability, remarkable cycling performance, non-toxic attributes, and cost-effectiveness. However, the increased adoption of LFP batteries has led to a surge in spent LFP battery disposal. Improper handling of waste LFP batteries could result in adverse consequences, including environmental degradation and the mismanagement of valuable secondary resources. This paper presents a comprehensive examination of waste LFP battery treatment methods, encompassing a holistic analysis of their recycling impact across five dimensions: resources, energy, environment, economy, and society. The recycling of waste LFP batteries is not only crucial for reducing the environmental pollution caused by hazardous components but also enables the valuable components to be efficiently recycled, promoting resource utilization. This, in turn, benefits the sustainable development of the energy industry, contributes to economic gains, stimulates social development, and enhances employment rates. Therefore, the recycling of discarded LFP batteries is both essential and inevitable. In addition, the roles and responsibilities of various stakeholders, including governments, corporations, and communities, in the realm of waste LFP battery recycling are also scrutinized, underscoring their pivotal engagement and collaboration. Notably, this paper concentrates on surveying the current research status and technological advancements within the waste LFP battery lifecycle, and juxtaposes their respective merits and drawbacks, thus furnishing a comprehensive evaluation and foresight for future progress.

Direct regeneration of spent LiFePO4 materials via a green and economical one-step hydrothermal process.

The rapid development of electronic devices, electric vehicles and mobile energy storage devices, has increasingly emphasized the shortage of lithium resources for us in lithium-ion batteries are developing rapidly. The key to the disposal of spent lithium-ion batteries is to carry out green and efficient regeneration. Herein, we propose a one-step hydrothermal process for the direct regeneration of spent LiFePO4. To reduce the Fe3+ in the spent LiFePO4, the hydroxyl group was oxidized to an aldehyde group via a decarburization reaction, with DL-malic acid utilized as a low-cost and environmentally friendly reducing agent. The effects of various different Li concentrations, hydrothermal times and hydrothermal temperatures on the performance of regenerated LiFePO4 were investigated. The results revealed optimal electrochemical performance under a Li concentration of 1.2 mol L-1, a hydrothermal time of 6 h, and a hydrothermal temperature of 100 °C. The cycling stability of LiFePO4 regenerated under these conditions considerably improved. The initial discharge specific capacity and the discharge specific capacity of the regenerated LFP after 200 cycles were 138.4 mAh g-1 and 136.6 mAh g-1. All coulomb efficiencies of the regenerated LFP were above 97.2 %, and the capacity retention rate was 98.7%. This developed method can therefore be considered a green and feasible means for regeneration of LiFePO4.

Closed-loop recycling of spent lithium-ion batteries based on selective sulfidation: An unconventional approach.

The facile recycling of spent lithium-ion batteries (LIBs) has attracted considerable attention because of its great importance to environmental protection and resource utilization. A novel process is developed for cyclic utilization of spent LiNixCoyMnzO2 (NCM) batteries. The spent NCM was converted into water-soluble Li2CO3, acid-dissolved MnO, and nickel-cobalt sulfides through selective sulfidation, based on roasting condition optimization and thermodynamic calculation. More than 98 % of lithium is extracted preferentially from calcined NCM through water leaching, and over 99 % of manganese is extracted selectively from water leaching residue with H2SO4 solution of 0.4 mol/L in the absence of additional reductant. The nickel and cobalt sulfides were concentrated into the leaching residue without metal impurities. The obtained Li2CO3, MnSO4, and nickel-cobalt sulfides can be regenerated as new NCM, showing good electrochemical performance, and its discharge capacity is 169.8 mAh/g at 0.2C. After 100 cycles at 0.2C, the discharge specific capacity can still be maintained at 143.24 mAh/g, and its capacity retention ratio is as high as 92  %. An environmental assessment and economic evaluation indicate that the process is an economical and eco-friendly approach for green recycling of spent LIBs.

Sustainability and affordability of Chinese-funded renewable energy project in sub-Saharan Africa: a hybridized solid oxide fuel cell, temperature sensors, and lithium-based solar system approach.

Renewable energy projects are at the crux of all Chinese-funded investment in sub-Saharan Africa, which accounts for some 56% of all Chinese-led investments globally. However, the prevailing problem is that about 568 million people were still without electricity access in 2019 across urban and rural areas in sub-Saharan Africa, which does not commensurate with the United Nations Sustainable Development Goal (SDG7) of ensuring affordable and clean energy for all. Previous studies have assessed and improved the efficiency of integrated power generation systems often combined on three levels, power plant, solar panel, and fuel cells, and integrated into national grids or off-grid systems for a sustainable supply of power. This study has included a lithium-ion storage system as a key component in a hybridized renewable energy generation system for the first time that has proven to be efficient and investment worthy. The study also examines the operational parameters of Chinese-funded power plant projects in sub-Saharan Africa and their effectiveness in achieving SDG-7. The novelty of this study is evident in the proposed integrated multi-level hybrid technology model of solid oxide fuel cells, temperature point sensors, and lithium batteries powered by a solar system and embedded in thermal power plants as an alternative electrical energy system for domestic and industrial use in sub-Saharan Africa. Performance analysis of the proposed power generation model indicates its complementary capacity of generating additional energy output with thermodynamics energy and exergy efficiencies of 88.2% and 67.0% respectively. The outcome of this study draws the attention of Chinese investors, governments in sub-Saharan African countries, and top industry players to the following: to consider refocusing their energy sector policy initiatives and strategies towards exploring the lithium resource base in Africa, optimizing energy generation cost, recouping optimal profit from their renewable energy technology investments, and making electricity supply clean, sustainable, and affordable for use in sub-Saharan Africa.

Assessment of lithium bioaccumulation by quinoa (Chenopodium quinoa willd.) and its implication for human health.

Lithium (Li) is the lightest alkali metal and 27th most abundant element in the earth crust. In traces, the element has medicinal value for various disorders in humans, however, its higher concentrations may lead to treatment-resistant depression and altered thyroid functioning. Quinoa (Chenopodium quinoa) has gained popularity owing to its halophytic nature and its potential use as an alternative to the traditional staple foods. However, quinoa response to Li-salt in terms of growth, Li accumulation potential and health risks associated with consumption of the quinoa seeds grown on Li-contaminated soils has not been explored yet. During this study, quinoa was exposed to various concentrations of Li (0, 2, 4, 8 and 16 mM) at germination as well as seedling stages. The results showed that seed germination was the highest (64% higher than control) at Li concentration of 8 mM. Similarly, at 8 mM doses of Li shoot length, shoot dry weight, root length, root dry weight and grain yield were increased by 130%, 300%, 244%, 858% and 185% than control. It was also revealed that Li increased the accumulation of calcium and sodium in quinoa shoots. Carotenoids contents were increased, but chlorophyll contents remained un-changed under Li application. The activities of antioxidants viz. Peroxide dismutase, catalase and super oxide dismutase were also increased with an increase in the levels of Li in the soil. Estimated daily intake and hazard quotient of Li in quinoa were less than the threshold level. It was concluded that Li concentration of 8 mM is useful for quinoa growth and it can be successfully grown on Li contaminated soils without causing any human health risks.

Environmental Benefit Assessment of Second-Life Use of Electric Vehicle Lithium-Ion Batteries in Multiple Scenarios Considering Performance Degradation and Economic Value.

Second-life use of electric vehicle lithium-ion batteries (LIBs) is an inevitable trend; however, battery performance degradation increases environmental loads. This study evaluated the life cycle environmental impacts of second-life use of LIBs in multiple scenarios, considering performance degradation and economic value. The results showed that a component replacement rate of retired LIBs below 50% made the batteries worthy of repurposing. Reusing whole packs of retired LIBs was better than using only cells or modules owing to the environmental loads from diagnosis, disassembly, replacement, and test processes. The battery energy density and performance degradation significantly affect the maximum return on the environmental input. Compared with lithium iron phosphate (LFP) batteries, new lithium nickel manganese cobalt oxide (NMC) batteries, or lead-acid batteries, using retired NMC-811 batteries with capacities as low as 60.7% for energy storage systems to store wind electricity rather than hybrid or photovoltaic electricity, had substantial environmental benefits, including a low global warming potential. Considering the costs of battery recycling, labor, and electricity, using whole packs of retired LIBs could simultaneously achieve high economic and environmental values in energy storage and peak shaving scenarios.

Lithium Ferrocyanide Catholyte for High-Energy and Low-cost Aqueous Redox Flow Batteries.

Aqueous redox flow batteries (ARFBs) are a promising technology for grid-scale energy storage, however, their commercial success relies on redox-active materials (RAM) with high electron storage capacity and cost competitiveness. Herein, a redox-active material lithium ferrocyanide (Li4 [Fe(CN)6 ]) is designed. Li+ ions not only greatly boost the solubility of [Fe(CN)6 ]4- to 2.32 M at room temperature due to weak intermolecular interactions, but also improves the electrochemical performance of [Fe(CN)6 ]4-/3- . By coupling with Zn, ZIRFBs were built, and the capacity of the batteries was as high as 61.64 Ah L-1 (pH-neutral) and 56.28 Ah L-1 (alkaline) at a [Fe(CN)6 ]4- concentration of 2.30 M and 2.10 M. These represent unprecedentedly high [Fe(CN)6 ]4- concentrations and battery energy densities reported to date. Moreover, benefiting from the low cost of Li4 [Fe(CN)6 ], the overall chemical cost of alkaline ZIRFB is as low as $11 per kWh, which is one-twentieth that of the state-of-the-art VFB ($211.54 per kWh). This work breaks through the limitations of traditional electrolyte composition optimization and will strongly promote the development of economical [Fe(CN)6 ]4-/3- -based RFBs in the future.

Low-Cost, High-Strength Cellulose-based Quasi-Solid Polymer Electrolyte for Solid-State Lithium-Metal Batteries.

Solid-state lithium-metal batteries are considered as the next generation of high-energy-density batteries. However, their solid electrolytes suffer from low ionic conductivity, poor interface performance, and high production costs, restricting their commercial application. Herein, a low-cost cellulose acetate-based quasi-solid composite polymer electrolyte (C-CLA QPE) was developed with a high Li+ transference number ( t L i + ${{t}_{{{\rm L}{\rm i}}^{+}}}$ ) of 0.85 and excellent interface stability. The prepared LiFePO4 (LFP)|C-CLA QPE|Li batteries exhibited excellent cycle performance with a capacity retention of 97.7 % after 1200 cycles at 1 C and 25 °C. The experimental results and Density Function Theory (DFT) simulation revealed that the partially esterified side groups in the CLA matrix contribute to the migration of Li+ and enhance electrochemical stability. This work provides a promising strategy for fabricating cost-effective, stable polymer electrolytes for solid-state lithium batteries.

The Toxicological Analysis and Toxicological Risk Assessment of Chosen Elemental Impurities (Ag, Au, Co, Cr, Cs, Li, Mo, Se, and Sr) in Green Tea (Camellia sinensis (L.)) Infusions.

Our study's objective is to evaluate the potential health effects of elemental impurities (Ag, Au, Co, Cr, Cs, Li, Mo, Se, and Sr) found in green tea infusions (Camellia sinensis (L.)). The ICP-MS-based methodology was employed for elemental analysis and a detailed health risk evaluation based on weekly consumption (µg/L of infusion/week). The provisional tolerable weekly intake (PTWI), established by the Joint FAO Expert Committee on infusion/week/month based on existing literature data, was then compared to the subjects with data from the available literature. The exposure of the study items to Co ranged from 0.07904 to 0.85421 µg/day. On the contrary, the ICH (International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use) guidelines state that the established permitted daily exposure PDE (oral exposure) for Co is 50 µg/day. The PDE of lithium is around 560 µg/day, and according to our study, the estimated daily exposure of the evaluated products to Li fell between 0.0185 and 0.7170 µg/day. Our research also revealed modest concentrations of Cs (0.399-2.654 µg/L), Mo (0.0113-0.107 µg/L), and Sr (9.848-22.331 µg/L) in infusions. The recognized PDE for molybdenum is approximately 3400 µg/day. Only two samples contained silver, and when considering daily consumption, the predicted daily exposure to Ag is between 4.4994 and 0.03122 µg/day. The amounts of all evaluated elements in a daily dose of green tea infusions should not harm the consumer's health. Further considerations should take aspects, such as constant change and environmental pollution, into account.

SARS-CoV-2 specific T-cell humoral response assessment after COVID-19 vaccination using a rapid direct real-time PCR amplification.

OBJECTIVES: The SARS-CoV-2 immune response is mediated by both humoral and cellular immunity. In this study, SARS-CoV-2 specific cellular immunity was tested by a novel direct real-time PCR (dRT-PCR) assay, targeting mRNA of CXCL10, and compared with respect to an ELISA measuring interferon gamma (IFN-γ) release. METHODS: Whole blood (Li-He) and serum samples were collected from 92 healthcare workers (HCW), with three doses of homologous (Pfizer/BioNTech, n=74) or heterologous (Pfizer/BioNTech and Vaxzevria or Moderna, n=18) vaccinations. Li-He samples were incubated with SCV2 PANEL-1-T-ACTIVATION (Hyris srl, Lodi, Italy), or CoV-2 IGRA TUBE ELISA (Euroimmune, Lubeck, Germany). CXCL10 mRNA expression was analyzed by bCube/bApp (Hyris), while IFN-γ was evaluated by quant-T-Cell SARS-CoV-2 ELISA (Euroimmune). Anti-SARS-CoV-2 S-RBD IgG levels were measured in sera using a CLIA assay (Snibe, Shenzen, China). RESULTS: Imprecision of dRT-PCR assay was found to be satisfactory, and the two methods for measuring T cell immunity to SARS-CoV-2 peptides agreed in 82/87 (94.2%) of results. At qualitative dRT-PCR analyses, 81 subjects (93.2%) resulted as reactive to SARS-CoV-2 peptides, 3 (3.4%) were borderline and 3 were negative (3.4%). At univariate and multivariate analyses of quantitative dRT-PCR mRNA of CXCL10 and IFN-γ release results showed no difference between HCW with previous infection, homologous/heterologous vaccination, or demographical features. Anti-SARS-CoV-2 S-RBD IgG was associated with the previous infection and the time between the last vaccination or positivity. CONCLUSIONS: Direct RT-PCR appeared accurate for determining the presence or absence of immunoreactivity of SARS-CoV-2 specific T cells, especially when rapid analyses are required, such as for organ transplantation.

Private and External Costs and Benefits of Replacing High-Emitting Peaker Plants with Batteries.

Falling costs of lithium-ion (Li-ion) batteries have made them attractive for grid-scale energy storage applications. Energy storage will become increasingly important as intermittent renewable generation and more frequent extreme weather events put stress on the electricity grid. Environmental groups across the United States are advocating for the replacement of the highest-emitting power plants, which run only at times of peak demand, with Li-ion battery systems. We analyze the life-cycle cost, climate, and human health impacts of replacing the 19 highest-emitting peaker plants in California with Li-ion battery energy storage systems (BESS). Our results show that designing Li-ion BESS to replace peaker plants puts them at an economic disadvantage, even if facilities are only sized to meet 95% of the original plants' load events and are free to engage in arbitrage. However, five of 19 potential replacements do achieve a positive net present value after including monetized climate and human health impacts. These BESS cycle far less than typical front-of-the-meter batteries and rely on the frequency regulation market for most of their revenue. All projects offer net air pollution benefits but increase net greenhouse gas emissions due to electricity demand during charging and upstream emissions from battery manufacturing.

Electronic Health Record-Nested Reminders for Serum Lithium Level Monitoring in Patients With Mood Disorder: Randomized Controlled Trial.

BACKGROUND: Clinical guidelines recommend regular serum lithium monitoring every 3 to 6 months. However, in the real world, only a minority of patients receive adequate monitoring. OBJECTIVE: This study aims to examine whether the use of the electronic health record (EHR)-nested reminder system for serum lithium monitoring can help achieve serum lithium concentrations within the therapeutic range for patients on lithium maintenance therapy. METHODS: We conducted an unblinded, single-center, EHR-nested, parallel-group, superiority randomized controlled trial comparing EHR-nested reminders with usual care in adult patients receiving lithium maintenance therapy for mood disorders. The primary outcome was the achievement of therapeutically appropriate serum lithium levels between 0.4 and 1.0 mEq/L at 18 months after enrollment. The key secondary outcomes are included as follows: the number of serum lithium level monitoring except for the first and final monitoring; exacerbation of the mood disorder during the study period, defined by hospitalization, increase in lithium dose, addition of antipsychotic drugs or mood stabilizers, or addition or increase of antidepressants; adherence defined by the proportion of days covered by lithium carbonate prescription during the study period. RESULTS: A total of 111 patients were enrolled in this study. A total of 56 patients were assigned to the reminder group, and 55 patients were assigned to the usual care group. At the follow-up, 38 (69.1%) patients in the reminder group and 33 (60.0%) patients in the usual care group achieved the primary outcome (odds ratio 2.14, 95% CI 0.82-5.58, P=.12). The median number of serum lithium monitoring was 2 in the reminder group and 0 in the usual care group (rate ratio 3.62; 95% CI 2.47-5.29, P<.001). The exacerbation of mood disorders occurred in 17 (31.5%) patients in the reminder group and in 16 (34.8%) patients in the usual care group (odds ratio 0.97, 95% CI 0.42-2.28, P=.95). CONCLUSIONS: We found insufficient evidence for an EHR-nested reminder to increase the achievement of therapeutic serum lithium concentrations. However, the number of monitoring increased with relatively simple and inexpensive intervention. The EHR-based reminders may be useful to improve quality of care for patients on lithium maintenance therapy, and they have potentials to be applied to other problems. TRIAL REGISTRATION: University Hospital Medical Information Network Clinical Trials Registry UMIN000033633; https://tinyurl.com/5n7wtyav.