RESUMO
BACKGROUND: Reproductive health conditions such as endometriosis, uterine fibroids, and polycystic ovary syndrome (PCOS) affect a large proportion of women and people who menstruate worldwide. Prevalence estimates for these conditions range from 5% to 40% of women of reproductive age. Long diagnostic delays, up to 12 years, are common and contribute to health complications and increased health care costs. Symptom checker apps provide users with information and tools to better understand their symptoms and thus have the potential to reduce the time to diagnosis for reproductive health conditions. OBJECTIVE: This study aimed to evaluate the agreement between clinicians and 3 symptom checkers (developed by Flo Health UK Limited) in assessing symptoms of endometriosis, uterine fibroids, and PCOS using vignettes. We also aimed to present a robust example of vignette case creation, review, and classification in the context of predeployment testing and validation of digital health symptom checker tools. METHODS: Independent general practitioners were recruited to create clinical case vignettes of simulated users for the purpose of testing each condition symptom checker; vignettes created for each condition contained a mixture of condition-positive and condition-negative outcomes. A second panel of general practitioners then reviewed, approved, and modified (if necessary) each vignette. A third group of general practitioners reviewed each vignette case and designated a final classification. Vignettes were then entered into the symptom checkers by a fourth, different group of general practitioners. The outcomes of each symptom checker were then compared with the final classification of each vignette to produce accuracy metrics including percent agreement, sensitivity, specificity, positive predictive value, and negative predictive value. RESULTS: A total of 24 cases were created per condition. Overall, exact matches between the vignette general practitioner classification and the symptom checker outcome were 83% (n=20) for endometriosis, 83% (n=20) for uterine fibroids, and 88% (n=21) for PCOS. For each symptom checker, sensitivity was reported as 81.8% for endometriosis, 84.6% for uterine fibroids, and 100% for PCOS; specificity was reported as 84.6% for endometriosis, 81.8% for uterine fibroids, and 75% for PCOS; positive predictive value was reported as 81.8% for endometriosis, 84.6% for uterine fibroids, 80% for PCOS; and negative predictive value was reported as 84.6% for endometriosis, 81.8% for uterine fibroids, and 100% for PCOS. CONCLUSIONS: The single-condition symptom checkers have high levels of agreement with general practitioner classification for endometriosis, uterine fibroids, and PCOS. Given long delays in diagnosis for many reproductive health conditions, which lead to increased medical costs and potential health complications for individuals and health care providers, innovative health apps and symptom checkers hold the potential to improve care pathways.
Assuntos
Endometriose , Leiomioma , Humanos , Feminino , Endometriose/diagnóstico , Endometriose/complicações , Saúde Reprodutiva , Leiomioma/diagnóstico , Leiomioma/complicações , PrevalênciaRESUMO
The current study aimed to analyse and compare the vascularity of FIGO Type 4-7 leiomyoma specimens obtained from women with or without abnormal uterine bleeding (AUB). The records of 31 women who underwent myomectomy for FIGO Type 4-7 leiomyomas in a university hospital setting were analysed. Group I (n = 16) was composed of women that were symptomatic for AUB and group II (n = 15) consisted of asymptomatic cases. The myomectomy material(s) of each case were processed with CD34 staining and evaluated by Image J® software (Image J 1.52a, Wayne Rasband National Institutes of Health, Bethesda, MD). There was no statistically significant difference between the rates of vascular areas in the specimens of the two groups (p>.05). Although areas with large vessels were higher in group I compared to group II, the difference did not reach statistical significance (p>.05). AUB caused by FIGO Type 4-7 leiomyomas seems to be related to factors other than vascular density.Impact StatementWhat is already known on this subject? Uterine leiomyomas are the most common benign gynaecologic neoplasms with a prevalence of approximately 40% in women of reproductive age. They are most often asymptomatic but when symptomatic, abnormal uterine bleeding (AUB) is one of the most commonly observed symptoms. Although there are some hypothetical explanations, the exact pathogenesis underlying leiomyoma-associated AUB has not yet been elucidated. Almost a century ago, the vascular abnormalities of fibroids were hypothesised as one of the etiopathological factors correlated with clinical symptoms, such as AUB, and current data suggest that the vascular map of leiomyomas consists of an avascular core surrounded by a vascularised capsule. To our knowledge, there are no studies in the literature comparing the histopathological evaluation of the vascularity scores of FIGO Type 4-7 leiomyomas in symptomatic (with AUB) and asymptomatic (without AUB) women.What the results of this study add? The study revealed that there was no statistically significant difference between the vascularity scores of FIGO Type 4-7 leiomyomas excised from the symptomatic and asymptomatic women. Large vessel densities also did not statistically significantly differ between the two groups.What the implications are of these findings for clinical practice and/or further research? This study revealed that AUB caused by FIGO Type 4-7 leiomyomas was related to factors other than vascular density.
Assuntos
Leiomioma/irrigação sanguínea , Neovascularização Patológica/patologia , Hemorragia Uterina/patologia , Miomectomia Uterina , Neoplasias Uterinas/irrigação sanguínea , Adulto , Feminino , Humanos , Leiomioma/complicações , Leiomioma/cirurgia , Pessoa de Meia-Idade , Neovascularização Patológica/complicações , Hemorragia Uterina/etiologia , Hemorragia Uterina/cirurgia , Neoplasias Uterinas/complicações , Neoplasias Uterinas/cirurgiaRESUMO
Background: Heavy menstrual bleeding (HMB) is one of the most common distressing complications of uterine fibroids (UF); however, data on the health care costs for treatments in women experiencing HMB associated with UF are lacking. The objective of this study was to compare the direct costs and treatments patterns for women diagnosed with UF+HMB, UF only, and HMB only in the United States. Materials and Methods: The study design was retrospective matched cohort study using claims data. Women, aged 18-51 years, comprising four cohorts (HMB only, UF only, UF+HMB, and controls) were identified in the IBM MarketScan® Commercial Claims and Encounters Database (October 1, 2007âSeptember 30, 2018) and matched by demographics and Charlson Comorbidity Index score. Baseline characteristics and treatments during the 12 months post-diagnosis were summarized descriptively. Costs (2018 U.S. dollars) during the post-diagnosis year were compared using analysis of variance. Results: Before matching, women with UF+HMB represented 54% of UF cases. Following diagnosis, 32% in the matched UF+HMB cohort had no treatment, 49% underwent surgeries/procedures with (12%) or without (37%) medications, and 18% received medications only. The mean all-cause total costs for UF+HMB ($16,762) exceeded that for UF only by 24% ($13,506) and HMB only by 50% ($11,135), and almost tripled the mean cost for the control cohort ($6,691) (all, p < 0.001). The mean diagnosis-related costs were significantly higher for UF+HMB ($8,741) than for UF only ($4,550) and HMB only ($3,081) (all, p < 0.0001). Surgery/procedure costs comprised 80% of diagnosis-related medical costs for UF+HMB. Conclusions: UF with HMB were associated with significant economic burden, driven primarily by surgical/procedural costs and treatment patterns.
Assuntos
Leiomioma , Menorragia , Estudos de Coortes , Feminino , Custos de Cuidados de Saúde , Humanos , Revisão da Utilização de Seguros , Leiomioma/complicações , Leiomioma/terapia , Menorragia/tratamento farmacológico , Menorragia/terapia , Estudos Retrospectivos , Estados Unidos/epidemiologiaRESUMO
OBJECTIVE: Evidence for an association between uterine leiomyoma and increased risk of endometriosis is limited by small sample sizes and short follow-up periods. We assessed this association in a large nationwide sample with 14 years of data. DESIGN: Data were sourced from Taiwan's Longitudinal Health Insurance Database 2000 (LHID2000). MATERIALS AND METHODS: We identified 31,239 women aged ≥20 years diagnosed with uterine leiomyoma (International Classification of Disease, Ninth Revision, Clinical Modification [ICD-9-CM] code 218) between Jan 1, 2000 and Dec 31, 2012, who were matched with 124,956 controls (1:4) by 5-year age groups and year of diagnosis. Follow-up was from the date of LHID2000 entry to the first occurrence of endometriosis, loss to follow-up, insurance termination, or until December 31, 2013, whichever was earlier. RESULTS: In Cox regression analysis, the adjusted hazard ratio (aHR) for endometriosis in women with uterine leiomyoma was 6.44 (95% CI, 6.18, 6.72) compared with controls. The risk of endometriosis was significantly increased in women with uterine leiomyoma and comorbidities of tube-ovarian infection (aHR 2.86; 95% CI, 1.28, 6.36), endometritis (1.14; 1.06, 1.24), infertility (1.26; 1.16, 1.37), or allergic diseases (1.11; 1.05, 1.17). Having both uterine leiomyoma and endometritis significantly increased the risk of endometriosis (aHR 6.73; 95% CI, 6.07, 7.45) versus having only uterine leiomyoma (6.61; 6.33, 6.91) or endometritis (1.49; 1.31, 1.69). Similarly, having both uterine leiomyoma and infertility significantly increased the risk of endometriosis (aHR 6.95; 95% CI, 6.21, 7.78) versus having only uterine leiomyoma (6.66; 6.38, 6.96) or infertility (1.78; 1.57, 2.02). CONCLUSIONS: A diagnosis of uterine leiomyoma appears to increase the risk of endometriosis. Patients presenting with uterine fibroids should be encouraged to give informed consent for possible simultaneous surgical treatment of endometriosis.
Assuntos
Endometriose/epidemiologia , Infertilidade/epidemiologia , Leiomioma/epidemiologia , Adulto , Idoso , Endometriose/etiologia , Endometriose/patologia , Feminino , Humanos , Infertilidade/patologia , Seguro Saúde , Leiomioma/complicações , Leiomioma/patologia , Pessoa de Meia-IdadeRESUMO
BACKGROUND: Uterine fibroids, the most common cause of gynecologic surgery, have a reported cumulative incidence of 59% among Black women in the U.S. Uterine fibroids negatively impact the quality of women's lives. No study has been found in the literature about fibroids in Haiti. We conducted a mixed methods study to assess the burden and risk factors of uterine fibroids, as well as their effects on women's quality of life. METHODS: A convergent mixed methods study was conducted between October 1, 2019 and January 31, 2020 at MUH's (Mirebalais University Hospital) OB-GYN outpatient department. Quantitatively, in a cross-sectional study 211 women completed consecutively a structured questionnaire. In-depth interviews with 17 women with fibroids and 7 family members were implemented for the qualitative component. Descriptive statistics were calculated for clinical and social demographic variables. Logistic regression was performed to examine associations between fibroids and related risk factors. An inductive thematic process was used to analyze the qualitative data. A joint display technique was used to integrate the results. RESULTS: Of 193 women analyzed 116 had fibroids (60.1%). The mean age was 41.3. Anemia was the most frequent complication- 61 (52.6%). Compared to women without uterine fibroids, factors associated with uterine fibroids included income decline (AOR = 4.7, 95% CI: 2.1-10.9, p = < 0.001), excessive expenses for transport (AOR = 4.4, 95% CI: 1.6-12.4, p = 0.005), and family history with uterine fibroids (AOR = 4.6, 95% CI: 1.6-13.6, p = 0.005). In contrast, higher level of education and micro polycystic ovarian syndrome were associated with lower prevalence (AOR = 0.3, 95% CI: 0.1-0.9, p = 0.021) and (AOR = 0.2, 95% CI: 0.1-0.97, p = 0.044), respectively. The qualitative findings delineate how contextual factors such as health system failures, long wait times, gender inequality and poverty negatively affect the quality of women's lives. The poverty cycle of uterine fibroids emerged. CONCLUSIONS: A vicious cycle of poverty negatively impacts access to care for uterine fibroids in Haiti. Health insurance, social support, and income generating activities may be keys to promote social justice through access to adequate care for women with uterine fibroids in Haiti.
Assuntos
Equidade em Saúde/estatística & dados numéricos , Leiomioma/complicações , Qualidade de Vida/psicologia , População Rural/estatística & dados numéricos , Neoplasias Uterinas/complicações , Adulto , Estudos Transversais , Feminino , Haiti , Humanos , Leiomioma/psicologia , Pessoa de Meia-Idade , Pobreza/estatística & dados numéricos , Prevalência , Fatores de Risco , Inquéritos e Questionários , Neoplasias Uterinas/psicologiaRESUMO
OBJECTIVES: To report patterns and patient characteristics associated with initiation of and persistence with medical therapies for uterine fibroid-related heavy menstrual bleeding. DESIGN: Retrospective cohort study. SETTING: US commercial insurance claims database. POPULATION: 41 561 women aged 18-54 years with uterine fibroids and heavy menstrual bleeding who initiated medical therapies from January 2000 through December 2013. METHOD: Multinomial logistic regression was used to assess patient characteristics associated with initiation and persistence. Cox proportional hazards regression was used on propensity score-matched cohorts to examine change from index medication. MAIN OUTCOMES MEASURES: Initiation of and persistence with four first-line medical therapies: short- and long-acting reversible contraceptive steroids, leuprolide acetate, and tranexamic acid. RESULTS: Most women (79.4%) took short-acting reversible contraceptive steroids as first-line therapy (index medication), whereas 9.5%, 8.5%, and 2.7% used long-acting reversible contraceptive steroids, leuprolide acetate, and tranexamic acid, respectively. During follow-up, 16 594 women (39.9%) switched to nonindex medication (18.4%) or procedural treatment (81.6%). In comparison with women taking short-acting steroids, those receiving long-acting steroids were less likely to switch [hazard ratio (HR) 0.84, 95% CI 0.79-0.91], whereas women taking leuprolide acetate (HR 2.44, 95% CI 2.27-2.62) or tranexamic acid (HR 1.44, 95% CI 1.26-1.65) were more likely to switch. Older age, emergency department visits, anaemia, and inflammatory disease diagnoses at baseline were associated with increased probability of discontinuing the index medication or switching to another therapy. CONCLUSIONS: Women with uterine fibroid-related heavy menstrual bleeding were more likely to persist with their initial therapy of long-acting reversible contraceptive steroid compared with other medical options. TWEETABLE ABSTRACT: 80% women with fibroid-related heavy menstrual bleeding use SARC, but LARC users are more persistent.
Assuntos
Anticoncepcionais Femininos/uso terapêutico , Leiomioma/complicações , Contracepção Reversível de Longo Prazo/estatística & dados numéricos , Menorragia/tratamento farmacológico , Adolescente , Adulto , Bases de Dados Factuais , Feminino , Humanos , Seguro Saúde , Menorragia/etiologia , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento , Estados Unidos , Adulto JovemRESUMO
BACKGROUND: Since 1995 uterine artery embolization has been described as an alternative for hysterectomy in patients with symptomatic fibroids. Many studies including several randomized controlled trials established uterine artery embolization as a valuable treatment. These randomized controlled trials reported outcomes in terms of health-related quality of life, clinical outcomes, efficacy, and cost-effectiveness after 1, 2, and 5 years of follow-up. OBJECTIVE: The purpose of this study was to compare clinical outcome and health-related quality of life 10 years after uterine artery embolization or hysterectomy in the treatment of heavy menstrual bleeding caused by uterine fibroids in a randomized controlled trial. STUDY DESIGN: In all, 28 Dutch hospitals recruited patients with symptomatic uterine fibroids who were eligible for hysterectomy. Patients were 1:1 randomly assigned to uterine artery embolization or hysterectomy. The outcomes assessed at 10 years postintervention were reintervention rates, health-related quality of life, and patient satisfaction, which were obtained through validated questionnaires. Study outcomes were analyzed according to original treatment assignment (intention to treat). RESULTS: A total of 177 patients were randomized from 2002 through 2004. Eventually 81 uterine artery embolization and 75 hysterectomy patients underwent the allocated treatment shortly after randomization. The remaining patients withdrew from the trial. The 10-year questionnaire was mailed when the last included patient had been treated 10 years earlier. The mean duration of follow-up was 133 months (SD 8.58) accompanied by a mean age of 57 years (SD 4.53). Questionnaires were received from 131 of 156 patients (84%). Ten years after treatment, 5 patients underwent secondary hysterectomy resulting in a total of 28 of 81 (35%) (24/77 [31%] after successful uterine artery embolization). Secondary hysterectomies were performed for persisting symptoms in all cases but 1 (for prolapse). After the initial treatment health-related quality of life improved significantly. After 10 years, generic health-related quality of life remained stable, without differences between both groups. The urogenital distress inventory and the defecation distress inventory showed a decrease in both groups, probably related to increasing age, without significant differences between study arms. Satisfaction in both groups remained comparable. The majority of patients declared being (very) satisfied about the received treatment: 78% of the uterine artery embolization group vs 87% in the hysterectomy group. CONCLUSION: In about two thirds of uterine artery embolization-treated patients with symptomatic uterine fibroids a hysterectomy can be avoided. Health-related quality of life 10 years after uterine artery embolization or hysterectomy remained comparably stable. Uterine artery embolization is a well-documented and less invasive alternative to hysterectomy for symptomatic uterine fibroids on which eligible patients should be counseled.
Assuntos
Histerectomia/métodos , Leiomioma/terapia , Menorragia/terapia , Embolização da Artéria Uterina/métodos , Neoplasias Uterinas/terapia , Adulto , Análise Custo-Benefício , Feminino , Seguimentos , Nível de Saúde , Humanos , Histerectomia/economia , Leiomioma/complicações , Menorragia/etiologia , Pessoa de Meia-Idade , Satisfação do Paciente , Qualidade de Vida , Retratamento , Inquéritos e Questionários , Resultado do Tratamento , Embolização da Artéria Uterina/economia , Neoplasias Uterinas/complicaçõesRESUMO
Even if usually asymptomatic, uterine myomas have been associated with a number of clinical issues such as abnormal uterine bleeding (AUB), heavy menstrual bleeding (HMB), infertility, recurrent pregnancy loss, especially when these masses are submucous. Golden standard treatment for symptomatic submucous fibroids has long been considered their laparotomic removal or a total hysterectomy. The development of endoscopy has made these fibroids accessible and removable from the inner surface of uterus. Hysteroscopy arose as a diagnostic technique, but then it also became an alternative surgical technique for many diseases, offering therapeutic and irreplaceable possibilities of treatment, avoiding major surgery on the one hand, and allowing the correction of pathologies specifically related to female fertility, on the other hand. Excision by slicing has been described as traditional resectoscopic submucosal myomectomy, but today there are new procedures among which the operator can choose, that allow overcoming the initial limitations of the traditional resectoscopic myomectomy in clinical practice.
Assuntos
Histeroscopia/métodos , Leiomioma/cirurgia , Miomectomia Uterina/métodos , Neoplasias Uterinas/cirurgia , Feminino , Humanos , Leiomioma/complicações , Leiomioma/patologia , Cuidados Pré-Operatórios/métodos , Neoplasias Uterinas/complicações , Neoplasias Uterinas/patologiaRESUMO
OBJECTIVE: To analyze the association between patient characteristics and the probability of undergoing any uterine-sparing procedure (endometrial ablation, myomectomy, and uterine artery embolization) compared with hysterectomy as the first uterine leiomyoma (index) procedure and the probability of undergoing a specific uterine-sparing procedure. METHODS: We conducted a retrospective analysis using a commercial insurance claims database containing more than 13 million enrollees annually. Based on the index procedure performed 2004-2009, women were classified into one of the four procedure cohorts. Eligible women were aged 25-54 years on the index date, continuously insured through 1-year baseline and 1-year follow-up, and had a baseline uterine leiomyoma diagnosis. Logistic regression was used to assess the association between patient characteristics and leiomyoma procedure. RESULTS: The study sample comprised 96,852 patients (endometrial ablation=12,169; myomectomy=7,039; uterine artery embolization=3,835; and hysterectomy=73,809). Patient characteristics associated with undergoing any uterine-sparing procedure compared with hysterectomy included health maintenance organization health plan enrollment, Northeast region residence, the highest income and education quintiles based on zip code, an age-race interaction, and baseline diagnoses including menstrual disorders, pelvic pain, anemia, endometriosis, genital prolapse, and infertility. Among those who had a uterine-sparing procedure, characteristics associated with undergoing uterine artery embolization or endometrial ablation compared with myomectomy included increasing age, being from the Midwest relative to the Northeast, and certain baseline conditions including menstrual disorder, pelvic pain, endometriosis, and infertility. CONCLUSION: Both clinical and nonclinical factors were associated with the receipt of alternatives to hysterectomy for uterine leiomyomas in commercially insured women.
Assuntos
Ablação por Cateter/estatística & dados numéricos , Histerectomia/estatística & dados numéricos , Leiomioma/cirurgia , Tratamentos com Preservação do Órgão/estatística & dados numéricos , Embolização da Artéria Uterina/estatística & dados numéricos , Miomectomia Uterina/estatística & dados numéricos , Neoplasias Uterinas/cirurgia , Adulto , Negro ou Afro-Americano/estatística & dados numéricos , Fatores Etários , Escolaridade , Endometriose/complicações , Feminino , Sistemas Pré-Pagos de Saúde/estatística & dados numéricos , Humanos , Renda/estatística & dados numéricos , Infertilidade Feminina/complicações , Leiomioma/complicações , Distúrbios Menstruais/complicações , Pessoa de Meia-Idade , Dor Pélvica/complicações , Probabilidade , Estudos Retrospectivos , Estados Unidos , Neoplasias Uterinas/complicações , Prolapso Uterino/complicaçõesRESUMO
OBJECTIVE: To provide recommendations regarding the best management of fibroids in couples who present with infertility. Usual and novel treatment options for fibroids will be reviewed with emphasis on their applicability in women who wish to conceive. OPTIONS: Management of fibroids in women wishing to conceive first involves documentation of the presence of the fibroid and determination of likelihood of the fibroid impacting on the ability to conceive. Treatment of fibroids in this instance is primarily surgical, but must be weighed against the evidence of surgical management improving clinical outcomes, and risks specific to surgical management and approach. OUTCOMES: The outcomes of primary concern are the improvement in pregnancy rates and outcomes with management of fibroids in women with infertility. EVIDENCE: Published literature was retrieved through searches of PubMed, MEDLINE, the Cochrane Library in November 2013 using appropriate controlled vocabulary (e.g., leiomyoma, infertility, uterine artery embolization, fertilization in vitro) and key words (e.g., fibroid, myomectomy). Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies published in English and French. There were no date restrictions. Searches were updated on a regular basis and incorporated in the guideline to November 2013. Grey (unpublished literature) was identified through searching the websites of health technology assessment and health technology-related agencies, clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies. VALUES: The quality of evidence in this document was rated using the criteria described by the Canadian Task Force on Preventive Health Care (Table). BENEFITS, HARMS, AND COSTS: These recommendations are expected to allow adequate management of women with fibroids and infertility, maximizing their chances of pregnancy by minimizing risks introduced by unnecessary myomectomies. Reducing complications and eliminating unnecessary interventions are also expected to decrease costs to the health care system. Summary Statements 1. Subserosal fibroids do not appear to have an impact on fertility; the effect of intramural fibroids remains unclear. If intramural fibroids do have an impact on fertility, it appears to be small and to be even less significant when the endometrium is not involved. (II-3) 2. Because current medical therapy for fibroids is associated with suppression of ovulation, reduction of estrogen production, or disruption of the target action of estrogen or progesterone at the receptor level, and it has the potential to interfere in endometrial development and implantation, there is no role for medical therapy as a stand-alone treatment for fibroids in the infertile population. (III) 3. Preoperative assessment of submucosal fibroids is essential to the decision on the best approach for treatment. (III) 4. There is little evidence on the use of Foley catheters, estrogen, or intrauterine devices for the prevention of intrauterine adhesions following hysteroscopic myomectomy. (II-3) 5. In the infertile population, cumulative pregnancy rates by the laparoscopic and the minilaparotomy approaches are similar, but the laparoscopic approach is associated with a quicker recovery, less postoperative pain, and less febrile morbidity. (II-2) 6. There are lower pregnancy rates, higher miscarriage rates, and more adverse pregnancy outcomes following uterine artery embolization than after myomectomy. (II-3) Studies also suggest that uterine artery embolization is associated with loss of ovarian reserve, especially in older patients. (III) Recommendations 1. In women with infertility, an effort should be made to adequately evaluate and classify fibroids, particularly those impinging on the endometrial cavity, using transvaginal ultrasound, hysteroscopy, hysterosonography, or magnetic resonance imaging. (III-A) 2. Preoperative assessment of submucosal fibroids should include, in addition to an assessment of fibroid size and location within the uterine cavity, evaluation of the degree of invasion of the cavity and thickness of residual myometrium to the serosa. A combination of hysteroscopy and transvaginal ultrasound or hysterosonography are the modalities of choice. (III-B) 3. Submucosal fibroids are managed hysteroscopically. The fibroid size should be < 5 cm, although larger fibroids have been managed hysteroscopically, but repeat procedures are often necessary. (III-B) 4. A hysterosalpingogram is not an appropriate exam to evaluate and classify fibroids. (III-D) 5. In women with otherwise unexplained infertility, submucosal fibroids should be removed in order to improve conception and pregnancy rates. (II-2A) 6. Removal of subserosal fibroids is not recommended. (III-D) 7. There is fair evidence to recommend against myomectomy in women with intramural fibroids (hysteroscopically confirmed intact endometrium) and otherwise unexplained infertility, regardless of their size. (II-2D) If the patient has no other options, the benefits of myomectomy should be weighed against the risks, and management of intramural fibroids should be individualized. (III-C) 8. If fibroids are removed abdominally, efforts should be made to use an anterior uterine incision to minimize the formation of postoperative adhesions. (II-2A) 9. Widespread use of the laparoscopic approach to myomectomy may be limited by the technical difficulty of this procedure. Patient selection should be individualized based on the number, size, and location of uterine fibroids and the skill of the surgeon. (III-A) 10. Women, fertile or infertile, seeking future pregnancy should not generally be offered uterine artery embolization as a treatment option for uterine fibroids. (II-3E).
Objectif : Formuler des recommandations quant à la façon optimale d'assurer la prise en charge des fibromes dans le contexte de l'infertilité. Les options habituelles et novatrices de prise en charge des fibromes seront analysées en mettant l'accent sur leur applicabilité chez les femmes qui souhaitent obtenir une grossesse. Options : La prise en charge des fibromes chez les femmes qui souhaitent obtenir une grossesse met d'abord en jeu la documentation de la présence des fibromes en question et la détermination de la probabilité que ces derniers affectent le potentiel génésique. Dans un tel contexte, la prise en charge des fibromes s'effectue principalement de façon chirurgicale; toutefois, il faut s'assurer au préalable de mettre en balance les avantages factuels de l'approche chirurgicale en matière d'amélioration des issues cliniques et les risques propres à une telle approche. Issues : L'amélioration des taux et des issues de grossesse que permet la prise en charge des fibromes chez les femmes aux prises avec l'infertilité constitue l'issue principale sur laquelle nous nous sommes attardés. Résultats : La littérature publiée a été récupérée par l'intermédiaire de recherches menées dans PubMed, CINAHL et Cochrane Systematic Reviews en novembre 2013 au moyen d'un vocabulaire contrôlé (p. ex. « leiomyoma ¼, « infertility ¼, « uterine artery embolization ¼, « fertilization in vitro ¼) et de mots clés (p. ex. « fibroid ¼, « myomectomy ¼) appropriés. Les résultats ont été restreints aux analyses systématiques, aux études observationnelles et aux essais comparatifs randomisés / essais cliniques comparatifs publiés en anglais et français. Aucune restriction n'a été appliquée en matière de date. Les recherches ont été mises à jour de façon régulière et intégrées à la directive clinique jusqu'en novembre 2013. La littérature grise (non publiée) a été identifiée par l'intermédiaire de recherches menées dans les sites Web d'organismes s'intéressant à l'évaluation des technologies dans le domaine de la santé et d'organismes connexes, dans des collections de directives cliniques, dans des registres d'essais cliniques, et auprès de sociétés de spécialité médicale nationales et internationales. Valeurs : La qualité des résultats est évaluée au moyen des critères décrits par le Groupe d'étude canadien sur les soins de santé préventifs (Tableau). Avantages, désavantages et coûts : Les présentes recommandations devraient permettre la prise en charge adéquate des femmes qui présentent des fibromes et qui sont aux prises avec l'infertilité, et ce, par la maximisation de leurs chances de grossesse grâce à la minimisation des risques mis en cause par la tenue de myomectomies inutiles. L'atténuation des complications et l'élimination des interventions inutiles devraient également mener à une baisse des coûts pour le système de santé. Déclarations sommaires 1. Les fibromes sous-séreux ne semblent pas exercer un effet sur la fertilité; la question de savoir si les fibromes intramuraux exercent un effet quelconque à cet égard demeure sans réponse définitive. Quoi qu'il en soit, si les fibromes intramuraux exercent bel et bien un effet sur la fertilité, ce dernier semble être faible et être encore moins significatif lorsque l'endomètre n'est pas mis en cause. (II-3) 2. Puisque la prise en charge médicale des fibromes est actuellement associée à la suppression de l'ovulation, à la diminution de la production d'Åstrogènes ou à la perturbation de l'action ciblée des Åstrogènes ou de la progestérone au niveau des récepteurs et qu'une telle prise en charge dispose du potentiel de nuire au développement endométrial et à l'implantation, elle ne peut être utilisée à titre traitement autonome pour contrer les fibromes au sein de la population infertile. (III) 3. La tenue d'une évaluation préopératoire des fibromes sous-muqueux constitue un facteur essentiel pour la prise d'une décision quant à la meilleure approche thérapeutique à adopter. (III) 4. Nous ne disposons que de peu de données probantes quant à l'utilisation de sondes de Foley, d'Åstrogènes ou de dispositifs intra-utérins pour la prévention des adhérences intra-utérines à la suite d'une myomectomie hystéroscopique. (II-3) 5. Au sein de la population infertile, les approches laparoscopique et par minilaparotomie donnent lieu à des taux de grossesse cumulatifs semblables; toutefois, l'approche « laparoscopique ¼ est associée à une récupération plus rapide, à une atténuation de la douleur postopératoire et à moins de cas de morbidité fébrile. (II-2) 6. Par comparaison avec la myomectomie, l'embolisation de l'artère utérine donne lieu à des taux moindres de grossesse, à des taux accrus de fausse couche et à plus d'issues de grossesse indésirables. (II-3) Des études laissent également entendre que l'embolisation de l'artère utérine est associée à une atténuation de la réserve ovarienne, particulièrement chez les patientes plus âgées. (III) Recommandations 1. Chez les femmes qui sont aux prises avec l'infertilité, des efforts devraient être déployés pour que l'évaluation et la classification des fibromes (plus particulièrement en ce qui concerne ceux qui exercent des effets sur la cavité endométriale) soient adéquatement menées au moyen de l'échographie transvaginale, de l'hystéroscopie, de l'hystéroéchographie ou de l'imagerie par résonance magnétique. (III-A). 2. L'évaluation préopératoire des fibromes sous-muqueux devrait non seulement comprendre la détermination de la taille des fibromes et de leur emplacement dans la cavité utérine, mais également la détermination de l'épaisseur du myomètre résiduel se situant entre ces fibromes et la séreuse et celle du degré d'envahissement de la cavité. À cette fin, les modalités à privilégier sont les suivantes : l'utilisation combinée de l'hystéroscopie et de l'échographie transvaginale ou l'hystéroéchographie. (III-B) 3. La prise en charge des fibromes sous-muqueux s'effectue par hystéroscopie. La taille des fibromes devrait être inférieure à 5 cm, et ce, bien que des fibromes de plus grandes dimensions aient déjà été pris en charge par hystéroscopie; toutefois, la tenue d'une deuxième intervention est souvent nécessaire. (III-B) 4. L'hystérosalpingogramme ne constitue pas une modalité adéquate pour l'évaluation et la classification des fibromes. (III-D) 5. Chez les femmes qui présentent une infertilité autrement inexpliquée, les fibromes sous-muqueux devraient être retirés de façon à permettre une amélioration des taux de conception et de grossesse. (II-2) 6. Le retrait des fibromes sous-séreux n'est pas recommandé. (III-D) 7. Nous disposons de données probantes assez bonnes pour nous prononcer contre le recours à la myomectomie chez les femmes qui présentent des fibromes intramuraux (l'intégrité de l'endomètre ayant été confirmée par hystéroscopie) et une infertilité autrement inexpliquée, peu importe la taille des fibromes en question. (II-2D) Lorsque la patiente ne dispose d'aucune autre option, les avantages de la myomectomie devraient être mis en balance avec les risques mis en cause; de plus, la prise en charge des fibromes intramuraux devrait alors être personnalisée. (III-C) 8. Lorsque les fibromes sont retirés par voie abdominale, l'utilisation d'une incision utérine antérieure devrait être favorisée pour minimiser la formation postopératoire d'adhérences. (II-2A) 9. L'élargissement du recours à l'approche laparoscopique en matière de myomectomie pourrait être limité par le degré de difficulté technique qui est associé à cette intervention. La sélection des patientes devrait être personnalisée en fonction du nombre, de la taille et de l'emplacement des fibromes utérins, ainsi qu'en fonction des habiletés du chirurgien. (III-A) 10. D'ordre général, les femmes (fertiles ou infertiles) qui cherchent à obtenir une grossesse ne devraient pas se voir offrir une embolisation de l'artère utérine à titre d'option pour la prise en charge de leurs fibromes utérins. (II-3E).
Assuntos
Infertilidade Feminina/terapia , Leiomioma/terapia , Neoplasias Uterinas/terapia , Feminino , Humanos , Infertilidade Feminina/etiologia , Leiomioma/complicações , Leiomioma/patologia , Imagem por Ressonância Magnética Intervencionista , Masculino , Gravidez , Resultado do Tratamento , Procedimentos Cirúrgicos Ultrassônicos/métodos , Embolização da Artéria Uterina , Miomectomia Uterina , Neoplasias Uterinas/complicações , Neoplasias Uterinas/patologiaRESUMO
AIMS AND OBJECTIVES: This study was designed to document the Transvaginal Scan (TVS) findings in women presenting with infertility and menstrual irregularities at the University of Calabar Teaching Hospital. MATERIALS AND METHODS: Subjects were women of reproductive age presenting at the University of Calabar Teaching Hospital with menstrual irregularities and infertility over a two year period, February 2011-January 2013. As part of their management, transvaginal scans were done and findings included a substantial number with polycystic ovarian cysts. Therefore the ovaries were further analysed with controls. RESULTS: Out of seventy-one women with age distribution of 22 to 46years, twenty- four(33.8%) presented with infertility, the rest presented with either menstrual irregularity alone or in combination with infertility. Polycystic ovaries (PCO), chronic pelvic inflammatory disease and fibroids were the main pathologies seen. PCO was by far the commonest. Ovarian volumes and follicular numbers were significantly higher in women with PCO than in controls, whereas their average follicular sizes were lower. CONCLUSION: PCO is the major finding in women with menstrual irregularity and infertility in the Calabar area. This hitherto poorly recorded pathology should be actively investigated in women representing with these symptoms by the use of TVS.
Assuntos
Infertilidade Feminina/diagnóstico por imagem , Distúrbios Menstruais/diagnóstico por imagem , Adulto , Estudos de Casos e Controles , Endossonografia , Feminino , Humanos , Infertilidade Feminina/etiologia , Leiomioma/complicações , Leiomioma/diagnóstico por imagem , Distúrbios Menstruais/etiologia , Pessoa de Meia-Idade , Nigéria , Cistos Ovarianos/complicações , Cistos Ovarianos/diagnóstico por imagem , Doença Inflamatória Pélvica/complicações , Doença Inflamatória Pélvica/diagnóstico por imagem , Estudos Prospectivos , Neoplasias Uterinas/complicações , Neoplasias Uterinas/diagnóstico por imagem , Adulto JovemRESUMO
STUDY OBJECTIVE: To explore the interindividual and intraindividual variation of Pictorial Blood Loss Assessment Chart (PBAC) registrations of subjective perception of minimal, normal, and heavy menstrual bleeding in women using their usual sanitary protection. DESIGN: Retrospective study (Canadian Task Force classification II-3). SETTING: University tertiary hospital. PATIENTS: Women who had participated in 4 previously published prospective studies using PBAC as the outcome measure. INTERVENTIONS: Patients underwent hysteroscopic removal of polyps, laparoscopic occlusion of uterine vessels, or uterine artery embolization, and control subjects received no treatment. MEASUREMENTS AND MAIN RESULTS: PBAC scores, hemoglobin concentration, and subjective assessment of periodic blood loss were recorded in 429 women during 1049 menstrual cycles. The median PBAC values in groups of women who assessed their bleeding as light, normal, and heavy were 45.0, 116.0, and 254.5, respectively (p < .001). Sensitivity and specificity for specific PBAC cutoff points were calculated using a receiver operating characteristic curve. The maximum sensitivity for assessment of heavy periodic blood loss (78.5) was reached at a PBAC score of 160. The corresponding specificity was 75.8. At PBAC values below 130, 90% of the women reported normal blood loss, and 91% had hemoglobin values >12.0 g/dL. The reliability of repeated PBAC scores for individual measures was assessed via calculation of the intraclass correlation coefficient, which for repeated PBAC measurements was 0.86 (95% confidence interval, 0.80-0.90) for average measures. CONCLUSION: The interindividual variation was high, and the intraindividual variation was low. A low PBAC score may be used to define treatment end points for clinical use or in trials.
Assuntos
Menorragia/diagnóstico , Menstruação , Adulto , Feminino , Hemoglobinas , Humanos , Individualidade , Leiomioma/complicações , Leiomioma/cirurgia , Menorragia/etiologia , Menorragia/cirurgia , Pessoa de Meia-Idade , Pólipos/complicações , Pólipos/cirurgia , Reprodutibilidade dos Testes , Estudos Retrospectivos , Autorrelato , Sensibilidade e Especificidade , Embolização da Artéria Uterina , Doenças Uterinas/complicações , Doenças Uterinas/cirurgia , Hemorragia Uterina/diagnóstico , Hemorragia Uterina/etiologia , Hemorragia Uterina/cirurgia , Neoplasias Uterinas/complicações , Neoplasias Uterinas/cirurgiaRESUMO
BACKGROUND: In 2009 the Uterine Bleeding and Pain Women's Research Study (UBP-WRS) was conducted interviewing 21,479 women across 8 countries in order to gain patient-based prevalence data on uterine pain and bleeding indications and investigate uterine symptoms and women's treatment experiences. This article shows relevant results of the study for the indication uterine fibroids providing data on self-reported prevalence, symptomatology and management of uterine fibroids. METHODS: 2,500 women (USA: 4,500 women) in each country (Brazil, Canada, France, Germany, Italy, South Korea, the UK, the USA) completed an online survey. Women included were in their reproductive age (age group 15-49 years; USA: 18-49 years) and had ever experienced menstrual bleedings. Quotas were applied for age, region, level of education and household income of respondents. Variables have been analyzed descriptively and exploratory statistical tests have been performed. RESULTS: The self-reported prevalence of uterine fibroids ranged from 4.5% (UK) to 9.8% (Italy), reaching 9.4% (UK) to 17.8% (Italy) in the age group of 40-49 years. Women with a diagnosis of uterine fibroids reported significantly more often about bleeding symptoms than women without a diagnosis: heavy bleedings (59.8% vs. 37.4%), prolonged bleedings (37.3% vs. 15.6%), bleeding between periods (33.3% vs. 13.5%), frequent periods (28.4% vs. 15.2%), irregular and predictable periods (36.3% vs. 23.9%). Furthermore women with diagnosed uterine fibroids reported significantly more often about the following pain symptoms: pressure on the bladder (32.6% vs. 15.0%), chronic pelvic pain (14.5% vs. 2.9%), painful sexual intercourse (23.5% vs. 9.1%) and pain occurring mid-cycle, after and during menstrual bleeding (31.3%, 16.7%, 59.7%, vs. 17.1%, 6.4%, 52.0%). 53.7% of women reported that their symptoms had a negative impact on their life in the last 12 month, influencing their sexual life (42.9%), performance at work (27.7%) and relationship & family (27.2%). CONCLUSIONS: Uterine fibroid is a common concern in women at fertile age causing multiple bleeding and pain symptoms which can have a negative impact on different aspects in women's life.
Assuntos
Dispareunia/etiologia , Histerectomia/estatística & dados numéricos , Leiomioma , Distúrbios Menstruais/etiologia , Dor/etiologia , Hemorragia Uterina/etiologia , Adolescente , Adulto , Distribuição por Idade , Comparação Transcultural , Estudos Transversais , Dispareunia/epidemiologia , Feminino , Humanos , Internet , Leiomioma/complicações , Leiomioma/diagnóstico , Leiomioma/epidemiologia , Leiomioma/terapia , Distúrbios Menstruais/epidemiologia , Pessoa de Meia-Idade , Dor/epidemiologia , Prevalência , Hemorragia Uterina/epidemiologia , Adulto JovemRESUMO
OBJECTIVE: Submucous fibroids are a common cause of menstrual disturbance that can be treated by hysteroscopic resection. Preoperative patient selection is critical for the success of surgery and it is usually based on hysteroscopic assessment of fibroid protrusion into the uterine cavity. Three-dimensional saline contrast sonohysterography (3D-SCSH) provides additional information about the size and location of submucous fibroids, but it has not yet been evaluated for its usefulness in preoperative assessment. The aim of this study was to examine the potential value of various demographic and ultrasound variables for the prediction of successful submucous fibroid resection. METHODS: This was a prospective study of symptomatic women diagnosed with submucous fibroids who underwent 3D-SCSH prior to hysteroscopic resection. The women's age and parity and fibroid position, diameter, protrusion ratio, size of the intramural component and distance from the internal cervical os were all recorded. The outcome measure was success of a single hysteroscopic resection in achieving a complete excision of the fibroid. Univariate analysis and multivariate logistic regression analysis using a training set and a testing set were performed to investigate the prediction of successful fibroid resection. RESULTS: A total of 61 women with 67 fibroids were included in the study. There was a statistically significant difference between women who had complete and those who had incomplete resection in the mean protrusion ratio (67.8 (SD 14.5)% vs. 47.0 (SD 17.8)%; P = 0.001), the median maximum fibroid diameter (24.0 (interquartile range (IQR), 19.0-30.5) mm vs. 45.0 (IQR, 28.8-51.3) mm; P = 0.001) and the median size of the intramural component of the fibroid (8.0 (IQR, 4.0-11.5) mm vs. 16.5 (IQR, 12.5-29.3) mm; P = 0.001). Stepwise multivariate logistic regression analysis retained size of intramural component (odds ratio (OR) 0.511), parity (OR 0.002) and fibroid diameter (OR 0.843) as significant independent predictors of a complete fibroid resection. The model had an area under the receiver-operating characteristics curve of 0.975 (SE 0.039) for the training set (n = 39) and 0.864 (SE 0.090) for the testing set (n = 28). CONCLUSION: Submucous fibroid protrusion ratio, fibroid diameter and size of the fibroid's intramural component are significantly associated with the likelihood of successful fibroid resection. A logistic regression model can calculate individual probability of complete resection and may improve preoperative counseling of patients.
Assuntos
Endométrio/diagnóstico por imagem , Leiomioma/diagnóstico por imagem , Distúrbios Menstruais/diagnóstico por imagem , Miométrio/efeitos da radiação , Hemorragia Uterina/etiologia , Adulto , Endométrio/patologia , Feminino , Humanos , Leiomioma/complicações , Leiomioma/patologia , Modelos Logísticos , Distúrbios Menstruais/etiologia , Distúrbios Menstruais/patologia , Análise Multivariada , Miométrio/patologia , Período Pré-Operatório , Estudos Prospectivos , Ultrassonografia , Hemorragia Uterina/diagnóstico por imagem , Hemorragia Uterina/patologiaRESUMO
The objective of this literature review was to evaluate the results obtained at vaginal myomectomy. The databases consulted were Medline, Cochrane Library, National Guideline Clearinghouse, and Health Technology Assessment Database. Keywords used for research were colpotomy, myomectomy, and vaginal myomectomy, and then abdominal myomectomy, laparoscopic-assisted vaginal myomectomy, and laparoscopic myomectomy. Eight case series and 2 case reports were analyzed, and included 372 patients. Reported rates of conversion to laparotomy during the operation ranged from 0% to 17.6%. The most frequently described risk factors for conversion to laparotomy were location of the myoma in the fundus and a large volume of myoma to be extracted, although no maximum threshold size can be defined. Performing laparoscopy first does not seem to limit the risk. Reported rates of transfusion during the operation ranged from 0% to 40%. Several cases of pelvic abscess have been described, with reported frequency of 2.2% to 5.7%. Authors mentioned the role of the vaginal drain that is inserted at the end of the procedure. No specific studies have been performed on long-term effectiveness, postoperative adhesions, integrity of the scar, or subsequent fertility. There are no good controlled studies of this technique. Feasibility seems to be acceptable, although the risk of pelvic infection in the postoperative period may be increased. Long-term effectiveness and safety were not assessed. A vaginal approach may be considered an alternative to laparotomy or laparoscopy in surgery to treat accessible myomas, and seems to be the simplest method.
Assuntos
Histerectomia Vaginal , Laparoscopia , Leiomioma/cirurgia , Neoplasias Uterinas/cirurgia , Feminino , Humanos , Leiomioma/complicações , Leiomioma/patologia , Resultado do Tratamento , Neoplasias Uterinas/complicações , Neoplasias Uterinas/patologiaAssuntos
Histerectomia Vaginal , Distúrbios Menstruais/terapia , Adulto , Anticoncepcionais Femininos/administração & dosagem , Anticoncepcionais Femininos/economia , Análise Custo-Benefício , Embolização Terapêutica/efeitos adversos , Feminino , Humanos , Histerectomia Vaginal/economia , Dispositivos Intrauterinos Medicados/economia , Leiomioma/complicações , Leiomioma/terapia , Levanogestrel/administração & dosagem , Levanogestrel/economia , Menorragia/complicações , Menorragia/terapia , Pessoa de Meia-Idade , Neoplasias Uterinas/complicações , Neoplasias Uterinas/terapiaRESUMO
OBJECTIVE: To assess hysterectomy rates, type of hysterectomy, and other factors associated within the United States from 1990-1997. METHODS: A descriptive statistical analysis of national discharge data was undertaken. Data from the nationwide Inpatient Sample of the Healthcare Cost and Utilization Project (from which national estimates are generated based on a 20% stratified sample of US community hospitals) were used for the years 1990-1997. All women who underwent hysterectomy were identified using International Classification of Diseases, 9th Revision, Clinical Modification, procedure codes. Outcome measures included rate, type of hysterectomy, age of patients, length of stay, total hospital charges, and diagnostic categories. RESULTS: Rates of hysterectomy have not changed significantly over the years from 1990-1997. Rates for hysterectomy in 1990 were 5.5 per 1000 women and increased slightly by 1997 to 5.6 per 1000 women. The type of hysterectomy has changed, with laparoscopic hysterectomy accounting for 9.9% of cases by 1997, with a concomitant decline in abdominal hysterectomy but no substantial change in vaginal hysterectomy rates. Length of stay decreased and total charges increased for all types of hysterectomy. Vaginal hysterectomy and laparoscopic hysterectomy are associated with shorter length of stay than abdominal hysterectomy. Abdominal hysterectomy is the most common procedure (63.0% in 1997). CONCLUSION: The majority of hysterectomies are abdominal, and the most common indication is uterine fibroids. The introduction of alternative techniques for controlling abnormal uterine bleeding such as endometrial ablation has not had an impact on hysterectomy rates, and there has only been a limited uptake of laparoscopic approaches.
Assuntos
Histerectomia/estatística & dados numéricos , Adulto , Fatores Etários , Feminino , Custos Hospitalares , Hospitais Comunitários , Humanos , Histerectomia/economia , Histerectomia/métodos , Leiomioma/complicações , Leiomioma/cirurgia , Tempo de Internação/estatística & dados numéricos , Pessoa de Meia-Idade , Alta do Paciente/estatística & dados numéricos , Estados Unidos/epidemiologia , Hemorragia Uterina/complicações , Hemorragia Uterina/cirurgiaRESUMO
OVERVIEW: Abnormal uterine bleeding is a common gynecological symptom. The curettage can asses only 50-60% of endometrium surface, thereby leaving some changes unrevealed. Sonohysterography (SHG), which combines the distention of the uterine cavity trough saline solution and ultrasound examination, allows a more exact evaluation of uterine cavity abnormalities. OBJECTIVES: To assess the value of sonohysterography in the diagnosis and management of abnormal uterine bleeding. MATERIALS AND METHODS: 67 women with abnormal uterine bleeding and uterine cavity abnormalities confirmed by transvaginal ultrasound were examined with sonohysterography. RESULTS: Sonohysterography revealed 21 cases of submucous myomas, 22 endometrial polyps and 24 cases of endometrial hyperplasia. All patients underwent diagnostic hysteroscopy to verify the results. The sensitivity and specificity for sonohysterography were both 93%. The positive and negative predictive values were 96% and 93%, respectively. CONCLUSIONS: Sonohysterography is a sensitive and specific method for diagnosis of abnormal uterine bleeding. It allows faster and less invasive diagnosis. Given the low costs of examination sonhysterography can be used as an ambulatory procedure reducing delay of treatment.
Assuntos
Hemorragia Uterina/diagnóstico por imagem , Hemorragia Uterina/etiologia , Útero/diagnóstico por imagem , Adulto , Idoso , Hiperplasia Endometrial/complicações , Hiperplasia Endometrial/diagnóstico por imagem , Feminino , Humanos , Leiomioma/complicações , Leiomioma/diagnóstico por imagem , Pessoa de Meia-Idade , Sensibilidade e Especificidade , Cloreto de Sódio/uso terapêutico , Ultrassonografia , Neoplasias Uterinas/complicações , Neoplasias Uterinas/diagnóstico por imagemRESUMO
Uterine myomas are the most common tumours of the female genital tract and with menorrhagia provide the most common indications for hysterectomy. Whilst myomectomy is a surgical alternative, it is associated with greater morbidity and a higher blood transfusion rate. Arterial embolization of myomas is a nonsurgical treatment option that can be performed as an outpatient procedure, is cheaper than myomectomy, permits preservation of reproductive potential, and may not only be associated with less morbidity than myomectomy but also may not cause adhesions which could compromise fertility. This paper details 2 cases treated by this technique.