RESUMO
Some new derivatives of 5-alkylaminomethyl-3-benzoyl-7-oxo-6,7-dihydroisoxazolo[4,3- d]pyrimidine [II-VI] and 7-amine substituted 3-benzoyl-5-phenylisoxazolo[4,3-d]pyrimidine [VIII-X] were synthesized. Preliminary results of pharmacological screening of compounds synthesized as [II-V,IX,X] have been presented.
Assuntos
Comportamento Animal/efeitos dos fármacos , Psicotrópicos/síntese química , Pirimidinas/metabolismo , Convulsões/prevenção & controle , Animais , Desenho de Fármacos , Eletrochoque , Dose Letal Mediana , Masculino , Camundongos , Pentilenotetrazol/antagonistas & inibidores , Psicotrópicos/farmacologia , Psicotrópicos/toxicidade , Pirimidinas/química , Convulsões/induzido quimicamenteRESUMO
Synthesis and properties of new N-substituted amides of alpha-(1,1-ethylenedioxy)-ethyl-gamma-hydroxybutyric acid are described. The compounds were obtained by aminolysis of 3-(1,1-ethylenedioxy)-ethyltetra-hydrofuran-2-on with primary alkylarylamines. Preliminary pharmacological assessment revealed that the compounds exert weaker influence on the central nervous system than the reference gamma-hydroxybutyric acid. Three of the novel compounds offered some protection against pentetrazole-induced tonic seizures in mice.