A Brief Recent History of Women in Computational Chemistry at Vertex Pharmaceuticals.

Countless reports cite the importance of diversity in the academic, industrial, and government workplace. This article shares the different perspective on gender diversity from five women who have recently joined Vertex's computational chemistry group. It is written with the hope that other scientists will take the themes which resonant and adopt them to their own institutions to inspire the fostering of an inclusive environment while in pursuit of scientific discoveries.

Rothschild reversed: explaining the exceptionalism of biomedical research, 1971-1981.

The 'Rothschild reforms' of the early 1970s established a new framework for the management of government-funded science. The subsequent dismantling of the Rothschild system for biomedical research and the return of funds to the Medical Research Council (MRC) in 1981 were a notable departure from this framework and ran contrary to the direction of national science policy. The exceptionalism of these measures was justified at the time with reference to the 'particular circumstances' of biomedical research. Conventional explanations for the reversal in biomedical research include the alleged greater competence and higher authority of the MRC, together with its claimed practical difficulties. Although they contain some elements of truth, such explanations are not wholly convincing. Alternative explanations hinge on the behaviour of senior medical administrators, who closed ranks to ensure that de facto control was yielded to the MRC. This created an accountability deficit, which the two organizations jointly resolved by dismantling the system for commissioning biomedical research. The nature and working of medical elites were central to this outcome.

History and Outcomes of 50 Years of Physician-Scientist Training in Medical Scientist Training Programs.

Physician-scientists are needed to continue the great pace of recent biomedical research and translate scientific findings to clinical applications. MD-PhD programs represent one approach to train physician-scientists. MD-PhD training started in the 1950s and expanded greatly with the Medical Scientist Training Program (MSTP), launched in 1964 by the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health. MD-PhD training has been influenced by substantial changes in medical education, science, and clinical fields since its inception. In 2014, NIGMS held a 50th Anniversary MSTP Symposium highlighting the program and assessing its outcomes. In 2016, there were over 90 active MD-PhD programs in the United States, of which 45 were MSTP supported, with a total of 988 trainee slots. Over 10,000 students have received MSTP support since 1964. The authors present data for the demographic characteristics and outcomes for 9,683 MSTP trainees from 1975-2014. The integration of MD and PhD training has allowed trainees to develop a rigorous foundation in research in concert with clinical training. MSTP graduates have had relative success in obtaining research grants and have become prominent leaders in many biomedical research fields. Many challenges remain, however, including the need to maintain rigorous scientific components in evolving medical curricula, to enhance research-oriented residency and fellowship opportunities in a widening scope of fields targeted by MSTP graduates, to achieve greater racial diversity and gender balance in the physician-scientist workforce, and to sustain subsequent research activities of physician-scientists.

An Asymmetrical Network: National and International Dimensions of the Development of Mexican Physiology.

This article examines the history of Mexican physiology during the period 1910-60 when two noted investigators, José J. Izquierdo, first, and Arturo Rosenblueth, second, inscribed their work into an international network of medical research. The network had at its center the laboratory of Walter B. Cannon at Harvard University. The Rockefeller Foundation was its main supporter. Rosenblueth was quite familiar with the network because he worked with Cannon at Harvard for over ten years before returning to Mexico in the early 1940s. Izquierdo and Rosenblueth developed different strategies to face adverse conditions such as insufficient laboratory equipment, inadequate library resources, a small scientific community, and ephemeral political support. Both acquired local influence and international prestige, but the sources of financial and academic power remained in the United States. This case study provides insight into the circulation of scientific ideas and practices in an important Latin American country and suggests that the world's circulation of science among industrial and developing nations during the mid-twentieth century was intrinsically asymmetric but opened temporary opportunities for talented individuals and groups of researchers.

"To rid oneself of the uninvited guest": Robert Koch, Sergei Winogradsky and competing styles of practice in medical microbiology.

Does an infectious disease have one, singular pathogenic cause, or many interacting causes? In the discipline of medical microbiology, there is no definitive theoretical answer to this question: there, the conditions of aetiological possibility exist in a curious tension. Ever since the late 19th century, the "germ theory of disease"­"one disease, one cause"­ has co-existed with a much less well known theory of "multifactorality"­"one disease, many interacting causes". And yet, in practice, it is always a singular and never a multifactorial aetiology that emerges once the pathogenic world is brought into the field of medical perception. This paper seeks to understand why. Performing a detailed, genealogical reading of the 2003 severe acute respiratory syndrome (SARS) outbreak, it foregrounds a set of links that connect the practical diagnostic tools at work within contemporary, 21st century laboratories to the philosophical assumptions at work within late-19th century understandings of the "germ theory of disease".

The background to the proposition that plankton be used as food in the United Kingdom during the Second World War.

Food shortages, particularly of proteins, in Britain during the Second World War led to the suggestion re-surfacing that marine plankton might be harvested on an industrial scale first as human food, then turning to its potential use as a supplement to stock and poultry feed. The notion emanated in the United Kingdom from Sir John Graham Kerr, at Glasgow University. He encouraged Alister Hardy, at Hull, to develop the idea and the natural testing ground was the Clyde Sea Area (given the extensive history of plankton research at Millport). Unpublished documents from the archives of the Scottish Association for Marine Science shed new light on the interactions behind the scenes of this project between Kerr, Hardy and the Millport Marine Station's then director, Richard Elmhirst. Elmhirst, who was sceptical about the feasibility of the plan from the outset, went along with it; not least as a way of attracting welcome research funding during lean times but also, doubtless, regarding it as his patriotic duty in case the proposal proved worthwhile.

What more can plant scientists do to help save the green stuff?

The Global Strategy for Plant Conservation (GSPC) was the first such effort under the Convention on Biological Diversity (CBD), and had gone through a 3-year process to reach the level of maturity that enabled it to be approved by consensus by all Governments present at the key session in The Hague in April 2002. It provided a model for subsequent CBD workplans, with targets, and undoubtedly contributed to the 2010 target of reducing the rate of biodiversity loss. In the event, few of the targets were achieved, because of numerous constraints at both policy and implementation levels. Even so, the GSPC stands as an important milestone in the global effort to conserve biodiversity. However, few plant scientists can be satisfied that the essential steps are being taken to ensure the conservation of plants, although, of course, plant scientists are only one part of the complex effort that will be required. This paper offers some suggestions that might be worth consideration, building on the basic principle in politics that a strong constituency is necessary to victory. In other words, although plant scientists play a crucial role, plant conservation is too important to leave in their hands alone; far broader support is required, including from the private sector, agriculture, forestry, trade, economics, tourism and even the military. Although botanical science provides a solid foundation, other branches of science are also important, ranging from anthropology to zoology. The legal profession also has important contributions to make (as well as the ability to hamper progress ­ for example through using issues such as access and benefit sharing to limit the exchange of genetic materials for even noncommercial use). 2010 was the United Nations Year of Biodiversity, and the GSPC targets reached their due date. It therefore seems timely to add some additional perspectives to the effort to update the GSPC. This paper suggests ways to reach a far broader constituency, provides tools to those who are expected to achieve the targets, and suggests ways to build a strong international constituency to conserve the world's botanical wealth.

Strengthening the scientific contribution of botanic gardens to the second phase of the Global Strategy for Plant Conservation.

The need for action on the global environment is now well understood and governments, agencies, non-governmental organizations and botanic gardens have all been working in their various ways to promote environmental sustainability and reduce species and habitat loss for at least 10­20 years. The Global Strategy for Plant Conservation (GSPC) has been widely adopted, particularly by the botanic garden community, and has resulted in many successes despite failing to achieve its ultimate goal of halting the loss of plant biodiversity. The objectives and targets for Phase 2 of the GSPC, running from 2010 to 2020, mirror those of Phase 1 and had been largely agreed prior to their formal adoption at the Conference of the Parties to the Convention on Biological Diversity in Nagoya in October 2010. However, to be successful, the scientific contribution of botanic gardens needs to be strengthened, as does government policy and commitment. Botanic garden research to underpin conservation action, including the role of botanic garden horticulture, training and international capacity building, has a major part to play and needs to be better understood and better coordinated. We provide examples based on the experience of the Royal Botanic Garden Edinburgh in the UK and overseas. Government policy, at national and international levels, needs to reflect the fundamental importance of plant diversity in maintaining the biosphere and supporting humanity. The commitment of significant new resources is an essential prerequisite for success, but this needs to be well coordinated, inclusive of all stakeholders and carefully targeted. A further challenge is the need to integrate better the plant diversity-related activities of what are currently diverse and disconnected sectors, including agriculture, forestry, protected area management and botanic gardens.