Reducing the GAP between science and clinic: lessons from academia and professional practice - part A: perceptual-auditory judgment of vocal quality, acoustic vocal signal analysis and voice self-assessment. / Reduzindo o GAP entre a ciência e a clínica: lições da academia e da prática profissional ­ parte A: julgamento perceptivo-auditivo da qualidade vocal, análise acústica do sinal vocal e autoavaliação em voz.

During the XXVIII Brazilian Congress of SBFa, 24 specialists met and, from a leading position on scientific research as a tool for connecting laboratory and clinic, five fronts of knowledge of the voice specialty were discussed as following: Perceptual-auditory judgment of vocal quality; 2. Acoustic analysis of the vocal signal; 3. Voice self-assessment; 4. Traditional techniques of therapy; 5. Modern techniques of electrostimulation and photobiomodulation (PBMT) in voice. Part "a" of this publication was associated with the consolidation of the analyses of the first three aspects. The trend in the perceptual-auditory judgment of vocal quality was related to the use of standard protocols. The acoustic evaluation of the vocal signal is accessible and can be done descriptively or by extraction of parameters, thus preferring multiparametric measures. Finally, the analysis of the individual himself closes this triad of voice documentation, which will be the basis for the conclusion of the evaluation, reference for monitoring progress, and evaluation of treatment results.

No XXVIII Congresso Brasileiro da SBFa, 24 especialistas reuniram-se e, a partir de um posicionamento condutor sobre pesquisa científica como ferramenta de conexão entre laboratório e clínica, cinco frentes de conhecimento da especialidade de voz foram discutidas: 1. Julgamento perceptivo-auditivo da qualidade vocal; 2. Análise acústica do sinal vocal; 3. Autoavaliação em voz; 4. Técnicas tradicionais de terapia; 5. Técnicas modernas de eletroestimulação e fotobiomodulação em voz. A parte "a" desta publicação é a consolidação das análises dos três primeiros aspectos. A tendência no julgamento perceptivo-auditivo da qualidade vocal é o uso de protocolos padrão. A avaliação acústica do sinal vocal é acessível e pode ser feita de modo descritivo ou por extração de parâmetros, preferindo-se medidas multiparamétricas. Finalmente, a análise do próprio indivíduo fecha essa tríade de documentação fonoaudiológica, que será base para a conclusão da avaliação, referência para monitoramento do progresso e avaliação de resultado de tratamento.

Expressiveness of voice professionals: construction process of a speech-language pathology assessment script. / Expressividade do profissional da voz: processo de construção de um roteiro fonoaudiológico de observação.

PURPOSE: To create a consensus version of a speech-language pathology (SLP) script to assess the expressiveness of voice professionals. METHODS: The process was divided into three stages: stage 1 included a survey of the literature and classification of the variables found in the instruments used; in steps 2 and 3, through teamwork, expert judges (focus groups I and II) created and adapted, along with the researcher, a consensus version of the expressiveness assessment script. RESULTS: The initial list presented to the judges contained 48 variables found in the literature: 11 related to emotional and interpretation aspects, 20 associated with oral expressiveness, three related to issues of verbal expressiveness, and 14 related to nonverbal expressiveness. In stage 2, the initial version of the script of the focus group I resulted in a document with 28 parameters, distributed in three thematic assessment groups: general aspects of communication, with three parameters; aspects related to oral expressiveness, with 16 parameters; aspects associated with body expressiveness, with nine parameters. In stage 3, after adequacy by focus group II, the consensus version also resulted in 28 parameters, distributed in two thematic groups. CONCLUSION: The consensus version of the SLP expressiveness assessment script for voice professionals was finalized with 28 parameters, distributed in two thematic axes: initial impact of communication, with six parameters; expressiveness, with 22 parameters.

OBJETIVO: criar uma versão consenso de roteiro de observação fonoaudiológica da expressividade. MÉTODO: o processo foi dividido em três etapas sendo a primeira levantamento e classificação das variáveis encontradas nos instrumentos apresentados na literatura; e nas etapas 2 e 3, na direção de trabalho coletivo, juízes especialistas (grupo focal I e II) criaram e adequaram, junto com a pesquisadora, a versão consenso do roteiro de avaliação da expressividade. RESULTADOS: a lista inicial apresentada aos juízes continha 48 variáveis presentes na literatura, sendo 11 relacionados a aspectos emocionais e de interpretação, 20 à expressividade oral, três a aspectos relacionados à expressividade verbal e, finalmente, 14 à expressividade não verbal. Na etapa 2, a versão inicial do roteiro do grupo focal I resultou num documento com 28 parâmetros distribuídos em três grupos temáticos de avaliação: aspectos gerais de comunicação, com três parâmetros; aspectos relacionados à expressividade oral, com 16; e aspectos relacionados à expressividade corporal, com nove parâmetros. Na etapa 3, a versão consenso, após a adequação do grupo focal II, também foi finalizada com 28 parâmetros, distribuídos em dois eixos temáticos. CONCLUSÃO: a versão consenso do Roteiro Fonoaudiológico de Observação da Expressividade foi finalizada com 28 parâmetros, distribuídos em dois eixos temáticos sendo: de impacto inicial da comunicação, com seis parâmetros; e expressividade, com 22.

Expressividade do profissional da voz: processo de construção de um roteiro fonoaudiológico de observação / Expressiveness of voice professionals: construction process of a speech-language pathology assessment script

RESUMO Objetivo criar uma versão consenso de roteiro de observação fonoaudiológica da expressividade. Método o processo foi dividido em três etapas sendo a primeira levantamento e classificação das variáveis encontradas nos instrumentos apresentados na literatura; e nas etapas 2 e 3, na direção de trabalho coletivo, juízes especialistas (grupo focal I e II) criaram e adequaram, junto com a pesquisadora, a versão consenso do roteiro de avaliação da expressividade. Resultados a lista inicial apresentada aos juízes continha 48 variáveis presentes na literatura, sendo 11 relacionados a aspectos emocionais e de interpretação, 20 à expressividade oral, três a aspectos relacionados à expressividade verbal e, finalmente, 14 à expressividade não verbal. Na etapa 2, a versão inicial do roteiro do grupo focal I resultou num documento com 28 parâmetros distribuídos em três grupos temáticos de avaliação: aspectos gerais de comunicação, com três parâmetros; aspectos relacionados à expressividade oral, com 16; e aspectos relacionados à expressividade corporal, com nove parâmetros. Na etapa 3, a versão consenso, após a adequação do grupo focal II, também foi finalizada com 28 parâmetros, distribuídos em dois eixos temáticos. Conclusão a versão consenso do Roteiro Fonoaudiológico de Observação da Expressividade foi finalizada com 28 parâmetros, distribuídos em dois eixos temáticos sendo: de impacto inicial da comunicação, com seis parâmetros; e expressividade, com 22.

ABSTRACT Purpose To create a consensus version of a speech-language pathology (SLP) script to assess the expressiveness of voice professionals. Methods The process was divided into three stages: stage 1 included a survey of the literature and classification of the variables found in the instruments used; in steps 2 and 3, through teamwork, expert judges (focus groups I and II) created and adapted, along with the researcher, a consensus version of the expressiveness assessment script. Results The initial list presented to the judges contained 48 variables found in the literature: 11 related to emotional and interpretation aspects, 20 associated with oral expressiveness, three related to issues of verbal expressiveness, and 14 related to nonverbal expressiveness. In stage 2, the initial version of the script of the focus group I resulted in a document with 28 parameters, distributed in three thematic assessment groups: general aspects of communication, with three parameters; aspects related to oral expressiveness, with 16 parameters; aspects associated with body expressiveness, with nine parameters. In stage 3, after adequacy by focus group II, the consensus version also resulted in 28 parameters, distributed in two thematic groups. Conclusion The consensus version of the SLP expressiveness assessment script for voice professionals was finalized with 28 parameters, distributed in two thematic axes: initial impact of communication, with six parameters; expressiveness, with 22 parameters.

Developing a large scale population screening tool for the assessment of Parkinson's disease using telephone-quality voice.

Recent studies have demonstrated that analysis of laboratory-quality voice recordings can be used to accurately differentiate people diagnosed with Parkinson's disease (PD) from healthy controls (HCs). These findings could help facilitate the development of remote screening and monitoring tools for PD. In this study, 2759 telephone-quality voice recordings from 1483 PD and 15 321 recordings from 8300 HC participants were analyzed. To account for variations in phonetic backgrounds, data were acquired from seven countries. A statistical framework for analyzing voice was developed, whereby 307 dysphonia measures that quantify different properties of voice impairment, such as breathiness, roughness, monopitch, hoarse voice quality, and exaggerated vocal tremor, were computed. Feature selection algorithms were used to identify robust parsimonious feature subsets, which were used in combination with a random forests (RFs) classifier to accurately distinguish PD from HC. The best tenfold cross-validation performance was obtained using Gram-Schmidt orthogonalization and RF, leading to mean sensitivity of 64.90% (standard deviation, SD, 2.90%) and mean specificity of 67.96% (SD 2.90%). This large scale study is a step forward toward assessing the development of a reliable, cost-effective, and practical clinical decision support tool for screening the population at large for PD using telephone-quality voice.

Vocal assessment of addicts on methadone therapy via the RBH scale and objective acoustic parameters / Avaliação da voz de drogaditos em terapia com metadona através da escala de rugosidade, soprosidade e aspereza, e parâmetros acústicos objetivos

Abstract Introduction: A large number of people around the world struggle daily to become free of their addiction to illegal psychoactive substances. In order to create an atmosphere of improved supervision, established communication and improved quality of life for drug addicts, centers have been set up to provide methadone as a substitute. Objective: The aim of the research was to assess the vocal features of drug addicts on methadone therapy via subjective and objective parameters, to ascertain if vocal damage has occurred and to determine whether subjective and objective acoustic vocal parameters are related, and how. Methods: The research included 34 adults of both genders who were undergoing methadone treatment. A subjective vocal evaluation assessed voice pitch and clarity, while the subjective acoustic analysis utilized the Roughness-Breathiness-Hoarseness scale of roughness-breathiness-hoarseness. Objective acoustic analysis was conducted after recording and analyzing an uninterrupted vocal /a/ of at least three seconds duration, using the "GllotisController" software. Results: The subjective acoustic analysis using the Roughness-Breathiness-Hoarseness scale showed pathological values in 52.9% male and 47% female participants. The average values of the roughness-breathiness-hoarseness for the entire sample were 0.91, 0.38 and 0.50, respectively. Lower roughness was associated with a higher fundamental frequency (f0) and lower jitter and shimmer values (p < 0.05). There was a statistically significant correlation between breathiness, jitter (p < 0.01) and shimmer (p < 0.05), and between hoarseness and jitter (p < 0.01). Conclusion: A statistically significant correlation was found between the two subjective vocal assessments, voice clarity and pitch, and Roughness-Breathiness-Hoarseness scale, and the parameters of the objective acoustic vocal assessment.

Resumo Introdução: Um grande número de pessoas em todo o mundo luta diariamente para livrar-se de seu vício em substâncias psicoativas ilegais. Com o objetivo de criar uma atmosfera de supervisão melhorada, comunicação estabelecida e melhora da qualidade de vida para drogaditos, foram criados centros que fornecem a substância substitutiva metadona. Objetivo: Avaliar a voz de drogaditos que recebem terapia com metadona através de parâmetros subjetivos e objetivos, para determinar o eventual dano à voz, bem como determinar se os parâmetros vocais acústicos subjetivos e objetivos estão interligados e como isso ocorre. Método: A pesquisa incluiu 34 participantes, usuários de terapia com metadona, de ambos os sexos. A avaliação vocal subjetiva consistiu na avaliação do tom (pitch) e clareza da voz, enquanto a análise acústica subjetiva consistiu no uso da escala RSA, de rugosidade, soprosidade e aspereza. A análise acústica objetiva foi realizada após a gravação e análise da vocalização ininterrupta de /a/ com duração de no mínimo três segundos, com o software GllotisController. Resultados: A análise acústica subjetiva utilizando a escala RSA mostrou valores patológicos em 52,9% de homens e 47% em mulheres. Os valores médios dos parâmetros rugosidade, soprosidade e aspereza para toda a amostra foram 0,91, 0,38 e 0,50, respectivamente. O parâmetro rugosidade mais baixo esteve associado a valores mais altos de frequência fundamental (f0) e menor jitter e o shimmer (p < 0,05). Entre o parâmetro soprosidade e o jitter (p < 0,01) e o shimmer (p < 0,05) houve uma correlação estatisticamente significante, bem como entre o parâmetro aspereza e o jitter (p < 0,01). Conclusão: Foi encontrada uma correlação estatisticamente significante entre a avaliação vocal subjetiva da clareza e do tom (pitch) da voz e os parâmetros da avaliação vocal acústica objetiva, bem como os parâmetros da análise vocal acústica subjetiva utilizando a escala de rugosidade, soprosidade e aspereza e os parâmetros acústicos objetivos.

Vocal assessment of addicts on methadone therapy via the RBH scale and objective acoustic parameters.

INTRODUCTION: A large number of people around the world struggle daily to become free of their addiction to illegal psychoactive substances. In order to create an atmosphere of improved supervision, established communication and improved quality of life for drug addicts, centers have been set up to provide methadone as a substitute. OBJECTIVE: The aim of the research was to assess the vocal features of drug addicts on methadone therapy via subjective and objective parameters, to ascertain if vocal damage has occurred and to determine whether subjective and objective acoustic vocal parameters are related, and how. METHODS: The research included 34 adults of both genders who were undergoing methadone treatment. A subjective vocal evaluation assessed voice pitch and clarity, while the subjective acoustic analysis utilized the Roughness-Breathiness-Hoarseness scale of roughness-breathiness-hoarseness. Objective acoustic analysis was conducted after recording and analyzing an uninterrupted vocal /a/ of at least three seconds duration, using the "GllotisController" software. RESULTS: The subjective acoustic analysis using the Roughness-Breathiness-Hoarseness scale showed pathological values in 52.9% male and 47% female participants. The average values of the roughness-breathiness-hoarseness for the entire sample were 0.91, 0.38 and 0.50, respectively. Lower roughness was associated with a higher fundamental frequency (f0) and lower jitter and shimmer values (p<0.05). There was a statistically significant correlation between breathiness, jitter (p<0.01) and shimmer (p<0.05), and between hoarseness and jitter (p<0.01). CONCLUSION: A statistically significant correlation was found between the two subjective vocal assessments, voice clarity and pitch, and Roughness-Breathiness-Hoarseness scale, and the parameters of the objective acoustic vocal assessment.

Influence of preoperative voice assessment on treatment plan prior to airway surgery.

OBJECTIVES/HYPOTHESIS: Voice quality has emerged as an additional long-term outcome measure for patients with a history of airway surgery. The goal of this study was to evaluate the impact of preoperative voice assessment on the surgical management of patients who required complex airway surgery. STUDY DESIGN: Retrospective case series. METHODS: We analyzed clinical data for all patients who underwent an airway reconstruction procedure from September 1, 2012 to September 1, 2017 and had a voice clinic evaluation prior to surgery at a tertiary-care pediatric hospital. Each participant underwent a full clinical voice evaluation that yielded acoustic, imaging, perceptual, and handicapping index data. RESULTS: Six hundred forty-three patients underwent 831 airway surgeries (laryngotracheoplasty, cricotracheal resection, slide tracheoplasty, laryngeal cleft repair). Ninety-one (14.2%) of the 643 patients underwent a formal voice clinic evaluation prior to airway surgery; 39/91 (42.9%) were female. The mean age was 10.4 years (95% confidence interval [CI]: 9.2-11.6) with 31/91 (32.9%) participants demonstrating vocal fold immobility and 33/91 (36.3%) vocal fold hypomobility. A voice clinic evaluation provided new information for 62/91 (68.1%) patients, mainly for laryngeal dynamic components (vocal fold motion, source of phonation, arytenoid prolapse) and confirmed suspected disorders for the remaining patients. The average baseline Pediatric Voice Handicap Index overall score was 38.9 (95% CI: 33.3-44.5), and the average overall severity rating of the Consensus Auditory-Perceptual Evaluation of Voice was 54 (95% CI: 45.2-62.8). A voice clinic evaluation influenced management of 56/91 (61.5%) patients either by modification of the surgical plan (26/56, 46%) and/or adjusting voice therapy (21/56, 37.5%). CONCLUSIONS: Voice evaluation prior to airway reconstruction provided key information that influenced the management for most of the patients. Formal voice evaluation should be considered prior to complex airway surgery. LEVEL OF EVIDENCE: 4 Laryngoscope, 128:2858-2863, 2018.

Assessment of Clinical and Social Characteristics That Distinguish Presbylaryngis From Pathologic Presbyphonia in Elderly Individuals.

Importance: An aging population experiences an increase in age-related problems, such as presbyphonia. The causes of pathologic presbyphonia are incompletely understood. Objective: To determine what distinguishes pathologic presbyphonia from presbylaryngis. Design, Setting, and Participants: This was a cohort study at an outpatient otolaryngology subspecialty clinic of a tertiary academic referral center. Participants were consecutive consenting adults older than 74 years without laryngeal pathologic abnormalities who visited the clinic as participants or companions. Patient questionnaires, otolaryngologic, video stroboscopic, and voice examinations were compiled. Patients were divided into groups based on whether they endorsed a voice complaint. Three blinded authors graded stroboscopic examinations for findings consistent with presbylaryngis (vocal fold bowing, vocal process prominence, glottic insufficiency). Main Outcomes and Measures: Voice Handicap Index-10, Reflux Symptom Index, Cough Severity Index, Dyspnea Index, Singing Voice Handicap Index-10 , Eating Assessment Tool -10, Voice-Related Quality of Life (VRQOL), and Short-Form Health Survey; face-sheet addressing social situation, work, marital status, education, voice use, transportation; acoustic and aerodynamic measures; and a full otolaryngologic examination, including videostroboscopic imaging. Results: A total of 31 participants with dysphonia (21 were female; their mean age was 83 years [range, 75-97 years]) and 26 control participants (16 were female; their mean age was 81 years [range, 75-103 years]) completed the study. Presbylaryngis was visible in 27 patients with dysphonia (87%) and 22 controls (85%). VHI-10 and VRQOL scores were worse in patients with pathologic presbyphonia (median [range] VHI-10 scores, 15 (0-40) vs 0 (0-16) and median VRQOL score, 19 [0-43] vs 10 [10-23]). All other survey results were indistinguishable, and no social differences were elucidated. Acoustic measures revealed that both groups averaged lower than normal speaking fundamental frequency (mean [SD], 150.01 [36.23] vs 150.85 [38.00]). Jitter was 3.44% (95% CI, 2.46%-4.61%) for pathologic presbyphonia and 1.74% (95% CI, 1.35%-2.14%) for controls (d = 0.75). Shimmer means (95% CI) were 7.8 2 (6.08-10.06) for the pathologic presbyphonia group and 4.84 (3.94-5.72) for controls (d = 0.69). Aerodynamic measures revealed an odds ratio of 3.03 (95% CI, 0.83-11.04) for patients with a maximum phonation time of less than 12 seconds who had complaints about dysphonia. Conclusions and Relevance: Presbylaryngis is present in most ambulatory people older than 74 years. Some will endorse pathologic presbyphonia that has a negative effect on their voice and quality of life. Pathologic presbyphonia seems to be influenced by respiratory capacity and sex. Further study is required to isolate other social, physiologic, and general health characteristics that contribute to pathologic presbyphonia.

[The comparative assessment of the vocal function in the professional voice users and non-occupational voice users in the late adulthood]. / Sravnitel'naia otsenka golosovoi funktsii u professionalov golosa pozhilogo vozrasta i lits negolosovykh professii.

The objective of the present study was to evaluate the clinical and functional condition of the voice apparatus in the elderly patients and to elaborate recommendations for the prevention of disturbances of the vocal function in the professional voice users. This comprehensive study involved 95 patients including the active professional voice users (n=48) and 45 non-occupational voice users at the age from 61 to 82 years with the employment history varying from 32 to 51 years. The study was designed to obtain the voice characteristics by means of the subjective auditory assessment, microlaryngoscopy, video laryngostroboscopy, determination of maximum phonation time (MPT), and computer-assisted acoustic analysis of the voice with the use of the MDVP Kay Pentaxy system. The level of anxiety of the patients was estimated based on the results of the HADS questionnaire study. It is concluded that the majority of the disturbances of the vocal function in the professional voice users have the functional nature. It is concluded that the method of neuro-muscular electrophonopedic stimulation (NMEPS) of laryngeal muscles is the method of choice for the diagnostics of the vocal function of the voice users in the late adulthood. It is recommended that the professional vocal load for such subjects should not exceed 12-14 hours per week. Rational psychotherapy must constitute an important component of the system of measures intended to support the working capacity of the voice users belonging to this age group.

A quantitative method for the assessment of dysarthrophonia in myasthenia gravis.

Speech and voice symptomatology (dysarthrophonia) are often reported by patients with myasthenia gravis (MG). However, they have been poorly investigated despite their significant impact on quality of life. Quantitative methods for the assessment of dysarthrοphonia could facilitate the evaluation of these common MG symptoms. The goal of this study was to investigate the phonatory (sustained phonation and reading) and speech (diadochokinesis) function in MG patients using quantitative measures. The voice/speech of 12 MG patients (7 with anti-AchR and 5 with anti-MuSK antibodies) and 24 age-matched healthy controls was recorded and analyzed using electroglottography (EGG) and speech acoustics. For the analysis of voice, the variables that were found to distinguish MG patients compared to healthy controls were a higher average fundamental frequency (P<0.05), a higher standard deviation of the average fundamental frequency (P<0.001), a higher mean fundamental frequency of the vibrating vocal folds (P<0.005) and a higher fundamental frequency range (P<0.005). The analysis of diadochokinesis showed that MG patients had a higher mean duration of the silent interval between a series of repetitive /pa/ syllables (P<0.05), of the sound /t/ (P=0.05) and of the silent interval between a series of repetitive /ka/syllables (P<0.05). No statistical differences were found in any of these variables between the MG subgroups with anti-AchR or anti-MuSK antibodies. This study demonstrates that non-invasive physiological methods (EGG and speech acoustics) offer essential tools for the assessment of dysarthrophonia in MG patients.

Assessment of Vibratory Characteristics in Children Following Airway Reconstruction Using Flexible and Rigid Endoscopy and Stroboscopy.

IMPORTANCE: Up to half of children have substantial dysphonia after airway reconstruction. Visual assessment of vocal function is valuable. Feasibility of flexible and rigid endoscopy has been reported; however, the clinical utility of stroboscopy has not been examined. Rating of vibratory characteristics, such as mucosal wave and amplitude of vibration, is essential for the development of interventions to improve voice outcomes. OBJECTIVE: To examine (1) clinicians' ratings of anatomical and physiological features in children following airway reconstruction on initial voice evaluation using videolaryngostroboscopy and (2) the relationship of age to the type of endoscopy used. DESIGN, SETTING, AND PARTICIPANTS: Retrospective medical record review of 32 patients aged 3 to 21 years evaluated for post­airway reconstruction dysphonia between July 2011 and July 2012 at a quaternary care children's hospital. INTERVENTIONS: Clinical voice evaluation protocol including rigid and/or flexible endoscopy with stroboscopy. MAIN OUTCOMES AND MEASURES: Demographic and voice quality characteristics were collected. The ability to complete endoscopy and ratings of anatomical and/or physiological features were assessed by a consensus of 4 clinicians. A t test was used to determine whether age was a significant factor in successful completion of videolaryngostroboscopy. RESULTS: Of 31 children who underwent flexible videolaryngostroboscopy, 22 (71%) examinations were completed with a distal chip endoscope and 9 (29%) with a fiberoptic. Significant differences were found in age between children who completed the distal chip vs. fiberoptic examination (mean [SD], 7.3 [2.7] vs. 5.5 [6.2] years; P = .05). Rigid endoscopy was attempted for 14 (44%) of 32 patients; 9 examinations (64%) were successful. Significant differences were found in age between patients for whom a rigid endoscopy could be successfully completed vs. those for whom it was not (mean [SD], 12.9 [3.4] vs. 6.2 [2.1] years; P < .001). Eighteen (56%) were glottic phonators, 8 (25%) supraglottic, and 6 (19%) aphonic. Vibratory characteristics were visible in 10 of 37 examinations (27%); 6 (16%) had ratable characteristics. CONCLUSIONS AND RELEVANCE: Endoscopy can be successfully completed in most children who have undergone airway reconstruction, most often using a distal chip endoscope.We found that vibratory characteristics were often not assessed adequately using videolaryngostroboscopy. Further work identifying imaging modalities that better display vibratory characteristics, such as high-speed videoendoscopy, may provide new insight into vocal function and lead to a more thorough evaluation.

Parameters of the assessment of voice quality and clinical manifestation of rheumatoid arthritis.

PURPOSE: The aim of the study was to investigate the voice quality parameters in 72 rheumatoid arthritis (RA) patients and their relationships with the clinical manifestations and disease activity. The control group consisted of 30 healthy subjects. MATERIAL AND METHODS: All RA patients were evaluated by extensive clinical, laboratory and radiographic studies. The phoniatric assessment included the analysis of vocal folds vibrations by digital stroboscopy (DS) of the larynx using HRES ENDOCAM 5562 system, digital kymography (DKG) and High-Speed Digital Imaging (HSDI) technique. The acoustic voice analysis was conducted using DiagnoScope Specialist program. RESULTS: Voice quality disorders were registered in 32 (44.44%) RA patients and observed more frequently in patients with moderate and severe activity (DAS28≥3.2) than in mild RA. In digital stroboscopy, confirmed by digital kymography, the hypofunctional dysphonia was observed especially in patients with DAS28≥3.2. Outcomes of the subjective assessment of voice quality were in accordance with the objective parameters and acoustic voice examination. CONCLUSIONS: In RA patients the most frequent voice quality disorders with hypofunctional dysphonia were registered. The relationships between voice quality disorders, clinical activity and radiographic progression of RA patients were observed. Digital stroboscopy, digital kymography, High-Speed Digital Imaging and acoustic voice analysis used in the complex diagnosis of RA confirmed the presence of pathological changes in the larynx. There is a need of cooperation between rheumatologists and phoniatricians in the diagnosis and treatment of dysphonia in RA patients.

Automatic assessment of voice quality in the context of multiple annotations.

Approaches to evaluate voice quality include perceptual analysis, and acoustical analysis. Perceptual analysis is subjective and depends mostly on the ability of a specialist to assess a pathology, whereas acoustical analysis is objective, but highly relies on the quality of the so called annotations that the specialist assigns to the voice signal. The quality of the annotations for acoustical analysis depends heavily on the expertise and knowledge of the specialist. We face a scenario where we have annotations performed by several specialists with different levels of expertise and knowledge. Traditional pattern recognition methods employed in acoustical analysis are no longer applicable, since these methods are designed for scenarios where a "ground-truth" label is assigned by the specialist. In this paper, we apply recent developments in machine learning for taking into account multiple annotators for acoustical analysis of voice signals. For the classification step we compare two techniques, one of them based on Gaussian Processes for regression with multiple annotators, and the other is a multi-class Logistic Regression model that measures the annotator performance in terms of sensitivity and specificity. The performance of classifiers is assessed in terms of Cohen's Kappa index. Results show that the multi-annotator classification schemes have better performance when compared to techniques based on a traditional classifier where the true label is estimated from the multiple annotations available using majority voting.

Vocal self-assessment: relation with the type of instrument, gender, age, and profession in individuals without vocal complaints.

OBJECTIVE: To obtain the vocal self-assessment rates of individuals without vocal complaints and relate them to gender, occupation, and age range. METHODS: This is an observational, analytical, and cross-sectional study. In this study, 601 individuals without vocal complaints, 241 men and 360 women, aged between 18 and 59 years (mean of 30.1 years) were included. The individuals were divided into following age groups: 18-29 years (n=353; 58.7%), 30-44 years (n=159; 26.5%), and 45-59 years (n=89; 14.8%); 136 individuals (22.6%) were voice professionals and 465 (77.4%) were nonprofessionals. The individuals answered a questionnaire with identification data and the protocols Voice-Related Quality of Life (V-RQOL), Voice Handicap Index (VHI), and Voice Activity and Participation Profile (VAPP). The data were statistically analyzed. RESULTS: Mean scores obtained in the V-RQOL, VHI, and VAPP were 95.5, 5.37, and 3.06, respectively. If we transfer these values to the base 100, differences were found in the scores of the VHI and VAPP. Women presented significantly lower scores in the V-RQOL and VHI. Moreover, there were no differences in the mean scores obtained by the different age groups. Regarding professional vocal use, there were differences in the VHI and VAPP, and the "nonprofessionals" presented lower VHI than professionals. CONCLUSION: The type of the instrument, gender, and profession variables can influence the vocal self-assessment results.

Multidimensional assessment of vocal changes in benign vocal fold lesions after voice therapy.

OBJECTIVE: To evaluate through a multidimensional protocol voice changes after voice therapy in patients with benign vocal fold lesions. METHODS: 65 consecutive patients affected by benign vocal fold lesions were enrolled. Depending on videolaryngostroboscopy the patients were divided into 3 groups: 23 patients with Reinke's oedema, 22 patients with vocal fold cysts and 20 patients with gelatinous polyp. Each subject received 10 voice therapy sessions and was evaluated, before and after voice therapy, through a multidimensional protocol including videolaryngostroboscopy, perception, acoustics, aerodynamics and self-rating by the patient. Data were compared using Wilcoxon signed-rank test. Kruskal-Wallis test was used to analyse the mean variation difference between the three groups of patients. Mann-Whitney test was used for post hoc analysis. RESULTS: Only in 11 cases videolaryngostroboscopy revealed an improvement of the initial pathology. However a significant improvement was observed in perceptual, acoustic and self-assessment ratings in the 3 groups of patients. In particular the parameters of G, R and A of the GIRBAS scale, and the noise to harmonic ratio, Jitter and shimmer scores improved after rehabilitation. A significant improvement of all the parameters of Voice Handicap Index after rehabilitation treatment was found. No significant difference among the three groups of patients was visible, except for self-assessment ratings. CONCLUSION: Voice therapy may provide a significant improvement in perceptual, acoustic and self-assessed voice quality in patients with benign glottal lesions. Utilization of voice therapy may allow some patients to avoid surgical intervention.

Electroglottography of speakers of Brazilian Portuguese through Objective Multiparameter Vocal Assessment (EVA).

UNLABELLED: EVA was designed to study various speech production parameters. OBJECTIVE: This paper aims to define the mean values for electroglottography tests of Brazilian Portuguese speakers on EVA. MATERIALS AND METHOD: The voices of 20 men and 20 women without voice-related complaints were analyzed through electroglottography so as to obtain reference values for normality. CASE STUDY: this is a descriptive cross-sectional study. RESULTS: The mean values for normal male voices were: F0 = 127.77 Hz; F0 coefficient of variation = 2.51%; absolute jitter = 1.707 Hz; relative average perturbation = 0.0083; jitter factor = 1.34%; jitter ratio = 13.45%; QF = 0.447. The values for female voices were: F0 = 204.87 Hz; F0 coefficient of variation = 1.58%; absolute jitter = 3.30Hz; relative average perturbation = 0.0102; jitter factor = 1.60%; jitter ratio = 16.23%; QF= 0.443. Wave type for the entire sample was categorized as tilted pulse. CONCLUSION: Statistically significant differences were found for gender on parameters average FO and absolute jitter. While using acoustic analysis software, users must be based on parameters inherent to the software program when analyzing the collected data.

Medidas eletroglotográficas em falantes do português brasileiro por meio do Método Multiparamétrico de Avaliação Vocal Objetiva Assistida (EVA) / Electroglottography of speakers of Brazilian Portuguese through Objective Multiparameter Vocal Assessment (EVA)

O Método Multiparamétrico de Avaliação Vocal Objetiva Assistida (EVA) foi projetado para o estudo da maioria dos parâmetros de produção da fala. OBJETIVO: Definir as medidas médias dos parâmetros eletroglotográficos em falantes do português brasileiro para o EVA. MATERIAL E MÉTODO: Foram analisadas 40 vozes, 20 homens e 20 mulheres sem queixa vocal, extraindo-se as medidas eletroglotográficas, a fim de obter valores de referência de normalidade. Estudo de caso: estudo descritivo com corte transversal. RESULTADOS: Os valores médios de normalidade encontrados nas vozes masculinas foram: F0 = 127,77 Hz, coeficiente de variação de F0 = 2,51%, jitter absoluto = 1,707 Hz, perturbação média relativa = 0,0083, jitter factor = 1,34%, jitter ratio = 13,45%, e QF = 0,447. Para vozes femininas, foram: F0 = 204,87 Hz, coeficiente de variação de F0 = 1,58%, jitterabsoluto = 3,30 Hz, perturbação média relativa = 0,0102, jitter factor = 1,60%, jitter ratio = 16,23%, e QF = 0,443. O tipo de onda foi em 100% da amostra classificada como pulso inclinado em ambos os gêneros. CONCLUSÃO: Houve diferença estatisticamente significante em relação ao gênero para os parâmetros de média F0 e jitterabsoluto. Ao utilizar um programa de análise acústica, os usuários devem basear-se em parâmetros inerentes ao próprio programa para realizar a análise dos dados coletados.

EVA was designed to study various speech production parameters. OBJECTIVE: This paper aims to define the mean values for electroglottography tests of Brazilian Portuguese speakers on EVA. MATERIALS AND METHOD: The voices of 20 men and 20 women without voice-related complaints were analyzed through electroglottography so as to obtain reference values for normality. Case study: this is a descriptive cross-sectional study. RESULTS: The mean values for normal male voices were: F0 = 127.77 Hz; F0 coefficient of variation = 2.51%; absolute jitter = 1.707 Hz; relative average perturbation = 0.0083; jitter factor = 1.34%; jitter ratio = 13.45%; QF = 0.447. The values for female voices were: F0 = 204.87 Hz; F0 coefficient of variation = 1.58%; absolute jitter = 3.30Hz; relative average perturbation = 0.0102; jitter factor = 1.60%; jitter ratio = 16.23%; QF= 0.443. Wave type for the entire sample was categorized as tilted pulse. CONCLUSION: Statistically significant differences were found for gender on parameters average FO and absolute jitter. While using acoustic analysis software, users must be based on parameters inherent to the software program when analyzing the collected data.

Tridimensional assessment of adductor spasmodic dysphonia pre- and post-treatment with Botulinum toxin.

Spasmodic dysphonia voices form, in the same way as substitution voices, a particular category of dysphonia that seems not suited for a standardized basic multidimensional assessment protocol, like the one proposed by the European Laryngological Society. Thirty-three exhaustive analyses were performed on voices of 19 patients diagnosed with adductor spasmodic dysphonia (SD), before and after treatment with Botulinum toxin. The speech material consisted of 40 short sentences phonetically selected for constant voicing. Seven perceptual parameters (traditional and dedicated) were blindly rated by a panel of experienced clinicians. Nine acoustic measures (mainly based on voicing evidence and periodicity) were achieved by a special analysis program suited for strongly irregular signals and validated with synthesized deviant voices. Patients also filled in a VHI-questionnaire. Significant improvement is shown by all three approaches. The traditional GRB perceptual parameters appear to be adequate for these patients. Conversely, the special acoustic analysis program is successful in objectivating the improved regularity of vocal fold vibration: the basic jitter remains the most valuable parameter, when reliably quantified. The VHI is well suited for the voice-related quality of life. Nevertheless, when considering pre-therapy and post-therapy changes, the current study illustrates a complete lack of correlation between the perceptual, acoustic, and self-assessment dimensions. Assessment of SD-voices needs to be tridimensional.

Perceptual assessment of resonance and velopharyngeal function.

Cleft lip is an anomaly that primarily affects aesthetics, whereas cleft palate is an anomaly that primarily affects function, particularly speech. In fact, the main reason for repairing the palate is to provide adequate structure and function for normal speech production. Despite undergoing palatoplasty surgery, 20 to 30% of children with repaired cleft palate will demonstrate some degree of velopharyngeal dysfunction, resulting in abnormal speech. Velopharyngeal dysfunction is also seen in individuals without a history of cleft palate for various reasons. Because the symptoms of velopharyngeal dysfunction have a variety of causes, a comprehensive evaluation is very important to make the appropriate recommendations for treatment. The purpose of this article is to discuss the clinical assessment of velopharyngeal function for speech, using low-tech and "no-tech" procedures.

Instrumental assessment of velopharyngeal closure for speech.

The presence of a palatal cleft at birth should not prevent good speech production in most children provided they have (1) appropriate surgical intervention to close the palate at or around the child's first birthday, (2) careful monitoring of speech development throughout childhood, (3) speech therapy when needed, and (4) secondary surgical or speech-prosthetic intervention when needed. When managed carefully by an experienced, well-prepared multidisciplinary team that applies the criteria listed above, ~70% of children with nonsyndromic palatal clefts will have no significant difficulties with speech intelligibility or speech quality due to velopharyngeal insufficiency by the time they enter elementary school. Speech assessment is the first step toward comprehensive team management of children with cleft palate. The purpose of this chapter is to describe the use of instrumentation in the evaluation of speech of children with palatal clefts, within the context of a multidisciplinary team. The focus of this article is on instruments that are used to supplement the perceptual assessment to document current speech status and plan management strategies.