Treatment Strategy for Pediatric Paratesticular Rhabdomyosarcoma Based on Chimeric Gene Assessment.

Rhabdomyosarcoma (RMS), a malignant tumor of the soft tissue, occurs in two major subtypes: embryonal and alveolar. A majority of pediatric RMS cases involve the embryonal type and occur in the soft tissues of the head and neck or the urogenital organs, which contain paratesticular tissues. We report herein two cases of pediatric paratesticular RMS. One case was embryonal, whereas the other case was alveolar; the latter exhibited PAX7-FOXO1 gene chimerism and rapid progression. Notably, this is the first report of pediatric paratesticular pure-type alveolar RMS in Japan.

[Value of diagnostic imaging for assessment of unsuccessful treatment of children with neoplastic diseases. Introductory comments based on personal examinations]. / Wartosc badan obrazowych dla diagnostyki niepowodzen leczenia dzieci z choroba nowotworowa. Doniesienie wstepne na podstawie wlasnych badan.

Diagnostic imaging has determined clinical application depending on kind of pathology and anatomical localisation. This is a precise and fine instrument for monitoring effects of treatment in childhood malignant tumours. Authors demonstrate examples of cases in which diagnostic imaging was the only method which revealed a relapse in situ, progression during chemotherapy or clinically unsuspected dissemination of tumours after many years.