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1.
Artigo em Inglês | MEDLINE | ID: mdl-35472110

RESUMO

Horizontal ridge augmentation is a common surgical procedure performed prior to or simultaneously with implant placement, depending on the extent of the ridge deficiency. Many horizontal augmentation surgical options have been developed, spanning a wide range of materials and techniques. Given the numerous permutations available, the most suitable strategy to regenerate ridge width for an individual case often confounds clinicians. Based on an extensive review of the literature, this article provides up-to-date technique selection guidelines, in the form of a decision tree, for predictable horizontal bone augmentation dependent on the amount of bone gain needed.


Assuntos
Aumento do Rebordo Alveolar , Aumento do Rebordo Alveolar/métodos , Transplante Ósseo/métodos , Árvores de Decisões , Implantação Dentária Endóssea/métodos , Regeneração Tecidual Guiada Periodontal/métodos , Humanos
2.
J Clin Periodontol ; 49(6): 528-536, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35415940

RESUMO

AIM: The modified minimally invasive surgical technique (M-MIST) optimizes wound stability in the treatment of intrabony defects. Short-term observations show similar results as with flap alone or adjunctive regenerative materials. This study aims to compare the stability of the long-term outcomes, complication-free survival, and costs of the three treatment options. MATERIALS AND METHODS: Forty-five intrabony defects in 45 patients were randomized to M-MIST alone (N = 15), combined with enamel matrix derivative (M-MIST + EMD, N = 15), or EMD plus bone-mineral-derived xenograph (M-MIST + EMD + BMDX, N = 15). Supportive periodontal care (SPC) and necessary re-treatment were provided for 10 years. RESULTS: Three subjects were lost to follow-up. Clinical attachment level differences between 1 and 10 years were -0.1 ± 0.7 mm for M-MIST, -0.1 ± 0.8 mm for M-MIST + EMD, and -0.3 ± 0.6 mm for M-MIST + EMD + BMDX (p > .05 for within- and between-group differences). Four episodes of recurrence occurred in the M-MIST group, four in the M-MIST + EMD group, and five in the M-MIST + EMD + BMDX group. No significant differences in complication-free survival were observed between the three groups (p = .47). Complication-free survival was 7.46 years (95% confidence interval: 7.05-7.87) for the whole population. The M-MIST + EMD + BMDX group lost one treated tooth. Data indicated no significant inter-group difference of the total cost of recurrence over 10 years. When the baseline cost of treatment was considered, the total cost was lower for M-MIST alone. CONCLUSIONS: Teeth with deep pockets associated with intrabony defects can be successfully maintained over the long term with either M-MIST alone or by adding a regenerative material in the context of a careful SPC programme. M-MIST alone provided similar short- and long-term benefits as regeneration, at a lower cost. These findings need to be confirmed in larger, independent studies.


Assuntos
Perda do Osso Alveolar , Proteínas do Esmalte Dentário , Periodontite , Perda do Osso Alveolar/cirurgia , Proteínas do Esmalte Dentário/uso terapêutico , Seguimentos , Regeneração Tecidual Guiada Periodontal/métodos , Humanos , Perda da Inserção Periodontal/tratamento farmacológico , Perda da Inserção Periodontal/cirurgia , Periodontite/tratamento farmacológico , Periodontite/cirurgia , Resultado do Tratamento
3.
Quintessence Int ; 53(6): 492-501, 2022 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-35274512

RESUMO

OBJECTIVE: The aim of the current article was to present a radiographic method to determine the surface area of newly formed periodontal attachment, as well as to analyze volumetric and morphologic changes after regenerative periodontal treatment. METHOD AND MATERIALS: In this retrospective study, 11 singular intrabony periodontal defects were selected for minimally invasive surgical treatment and 3D evaluation. 3D virtual models were acquired by the segmentation of pre- and postoperative CBCT scans. This study determined the surface area of baseline periodontal attachment (RSA-A) and defect-involved root surface (RSA-D) on the preoperative 3D models, and the surface area of new periodontal attachment (RSA-NA) on the postoperative models. Finally, cumulative change of periodontal attachment (∆RSA-A) was calculated and Boolean subtraction was applied on pre- and postoperative 3D models to demonstrate postoperative 3D hard tissue alterations. RESULTS: The average RSA-A was 84.39 ± 33.27 mm2, while the average RSA-D was 24.26 ± 11.94 mm2. The average surface area of RSA-NA after regenerative periodontal surgery was 17.68 ± 10.56 mm2. Additionally, ∆RSA-A was determined to assess the overall effects of ridge alterations on periodontal attachment, averaging 15.53 ± 12.47 mm2, which was found to be statistically significant (P = .00149). Lastly, the volumetric hard tissue gain was found to be 33.56 ± 19.35 mm3, whereas hard tissue resorption of 26.31 ± 38.39 mm3 occurred. CONCLUSION: The proposed 3D radiographic method provides a detailed understanding of new periodontal attachment formation and hard tissue alterations following regenerative surgical treatment of intrabony periodontal defects.


Assuntos
Perda do Osso Alveolar , Doenças Periodontais , Perda do Osso Alveolar/diagnóstico por imagem , Perda do Osso Alveolar/cirurgia , Seguimentos , Regeneração Tecidual Guiada Periodontal/métodos , Humanos , Perda da Inserção Periodontal/diagnóstico por imagem , Perda da Inserção Periodontal/cirurgia , Doenças Periodontais/cirurgia , Bolsa Periodontal/cirurgia , Estudos Retrospectivos , Resultado do Tratamento
4.
Artigo em Inglês | MEDLINE | ID: mdl-28196167

RESUMO

Volumetric changes were evaluated to assess the regenerative efficacy of demineralized freeze-dried bone allograft (DFDBA) with and without amnion membrane (AM) in Grade II furcation defects both clinically and radiographically using cone beam computed tomography (CBCT). Sites were randomly assigned to Group I (DFDBA) and Group II (DFDBA + AM). Clinical parameters such as probing pocket depth, clinical attachment level, gingival recession, and horizontal probing depth were assessed at baseline, 3 months, and 6 months. Radiographic dimensions of the defect height, width, depth, and volume were assessed at baseline and 6 months postoperatively. DFDBA used with AM resulted in significant improvement in clinical and radiographic parameters when compared with DFDBA alone. The mean reductions in radiographic volume of the defect were 11.15 ± 6.39 mL for Group I and 17.02 ± 10.86 mL for Group II. Greater reduction in volume indicated a greater amount of healed regenerated tissue in Group II patients.


Assuntos
Âmnio/transplante , Substitutos Ósseos/uso terapêutico , Transplante Ósseo/métodos , Tomografia Computadorizada de Feixe Cônico/métodos , Liofilização , Defeitos da Furca/terapia , Membranas Artificiais , Adulto , Perda do Osso Alveolar/cirurgia , Técnica de Descalcificação , Feminino , Defeitos da Furca/diagnóstico por imagem , Defeitos da Furca/cirurgia , Retração Gengival/cirurgia , Regeneração Tecidual Guiada Periodontal/métodos , Humanos , Índia , Masculino , Pessoa de Meia-Idade , Perda da Inserção Periodontal/cirurgia , Bolsa Periodontal/cirurgia
5.
J Clin Periodontol ; 44(1): 58-66, 2017 01.
Artigo em Inglês | MEDLINE | ID: mdl-27736011

RESUMO

AIM: Compare the long-term outcomes and costs of three treatment modalities in intra-bony defects. MATERIALS AND METHODS: Forty-five intra-bony defects in 45 patients had been randomly allocated to receive: modified papilla preservation technique with titanium-reinforced expanded-polytetrafluoroethylene (ePTFE) membranes (MPPT Tit, N = 15); access flap with expanded-PTFE membranes (Flap-ePTFE, N = 15) and access flap alone (Flap, N = 15). Supportive periodontal care (SPC) was provided monthly for 1 year, then every 3 months for 20 years. Periodontal therapy was delivered to sites showing recurrences. RESULTS: Forty-one patients complied with SPC. Four subjects were lost to follow-up. Clinical attachment-level differences between 1 and 20 years were -0.1 ± 0.3 mm (p = 0.58) in the MPPT Tit; -0.5 ± 0.1 mm (p = 0.003) in the Flap-ePTFE and -1.7 ± 0.4 mm (p < 0.001) in the Flap. At 20 years, sites treated with Flap showed greater attachment loss compared to MPPT Tit (1.4 ± 0.4 mm; p = 0.008) and to Flap-ePTFE (1.1 ± 0.4 mm; p = 0.03). Flap group lost two treated teeth. Five episodes of recurrences occurred in the MPPT Tit, six in the Flap-ePTFE and fifteen in the Flap group. Residual pocket depth at 1-year was significantly correlated with the number of recurrences (p = 0.002). Sites treated with flap had greater OR for recurrences and higher costs of re-intervention than regenerated sites over a 20-year follow-up period with SPC. CONCLUSIONS: Regeneration provided better long-term benefits than Flap: no tooth loss, less periodontitis progression and less expense from re-intervention over a 20-year period. These benefits need to be interpreted in the context of higher immediate costs associated with regenerative treatment. These initial observations need to be extended to larger groups and broader clinical settings.


Assuntos
Custos e Análise de Custo , Regeneração Tecidual Guiada Periodontal/economia , Regeneração Tecidual Guiada Periodontal/métodos , Periodontite/economia , Periodontite/cirurgia , Politetrafluoretileno , Retalhos Cirúrgicos , Titânio , Adulto , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Regeneração , Fatores de Tempo , Perda de Dente/epidemiologia , Resultado do Tratamento
6.
J Periodontal Res ; 52(3): 388-396, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27510312

RESUMO

BACKGROUND AND OBJECTIVES: Within the same surgical procedure, a great variability on achievement of clinical outcomes exists and may be associated to different molecular factors related to tissue healing. The aim of the present study was to assess the distribution of clinical success separately in regenerative therapy (REG) and open flap debridement (OFD) to evaluate if factors related with healing of epithelium, connective tissue and bone may be associated to the clinical outcome within each surgical procedure. MATERIAL AND METHODS: Sixteen patients underwent periodontal REG and nine patients underwent OFD. Periodontal wound fluid was collected at baseline, 3-5, 7, 14 and 21 d after surgery, and expression of wound healing proteins was assessed. Pocket depth and clinical attachment level were taken at baseline and at 6 mo of follow-up. Percentage pocket depth reduction and percentage clinical attachment level gain were computed. Patients were regarded as better or worse responders depending on their percentage pocket depth reduction or percentage clinical attachment level gain. RESULTS: Higher percentage of better responders was observed in the REG group (68.7%) compared to the OFD group (22.2%). At 21 d, no difference in the profile of most of the proteins emerged, with two exceptions, both regarding REG treatment. Bone morphogenetic protein-7 tended to increase in better responders and to decrease in worse responders. Matrix metalloproteinase-1 increased in worse responders and remained substantially unchanged in better responders. CONCLUSION: Local expression of matrix metalloproteinase-1 and bone morphogenetic protein-7 during wound healing is associated with the clinical performance of periodontal regenerative surgery. The use of local biomarkers offers the potential for real-time assessment of the periodontal healing process.


Assuntos
Regeneração Tecidual Guiada Periodontal , Cicatrização , Biomarcadores/análise , Proteína Morfogenética Óssea 7/análise , Feminino , Líquido do Sulco Gengival/química , Regeneração Tecidual Guiada Periodontal/métodos , Humanos , Metaloproteinase 1 da Matriz/análise , Pessoa de Meia-Idade , Desbridamento Periodontal , Bolsa Periodontal/metabolismo , Periodonto/cirurgia , Projetos Piloto , Gravidez , Estudos Prospectivos , Resultado do Tratamento
8.
Clin Implant Dent Relat Res ; 18(6): 1142-1152, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26996771

RESUMO

OBJECTIVES: Radiologic and biologic assessment of immediately restored Implants combined with guided bone regeneration (GBR) and free connective tissue graft. METHODS: 1-4 year retrospective study involving 34 patients treated with maxillary immediately restored anterior single-implants. Soft tissue dimensions, radiographic bone loss, and biological and prosthetic complications were assessed. RESULTS: During the mean follow up period of 29 months the study group presented a mean mesial bone loss of 1.10 ± 0.39 mm (range: 0.5-2.4 mm), and mean distal bone loss of 1.19 ± 0.41 mm (range: 0.4-2.1 mm). Mean periimplant probing depth of 3.49 mm (SD ± 1.06) and 2.35 (SD ± 0.52) for the contralateral tooth (highly significant p < 0.001). Bleeding on probing was present in 29.4% of the examined implant supported crown sites and 10.4% of the contralateral teeth (p < 0.001). CONCLUSIONS: Anterior maxillary single-tooth replacement, using GBR and connective tissue graft according to the concept of immediate implant placement, and non-functional restoration is an accepted treatment modality achieving favorable peri-implant soft tissue condition.


Assuntos
Tecido Conjuntivo/transplante , Implantação Dentária/métodos , Regeneração Tecidual Guiada Periodontal/métodos , Maxila/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia Dentária , Estudos Retrospectivos
9.
Int J Oral Maxillofac Surg ; 45(6): 683-7, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26876144

RESUMO

Cone beam computed tomography (CBCT) allows for a significantly lower radiation dose than conventional computed tomography (CT) scans and provides accurate images of the alveolar cleft area. The osteogenic effect of guided bone regeneration (GBR) vs. conventional alveolar bone grafting alone for alveolar cleft defects was evaluated in this study. Sixty alveolar cleft patients were divided randomly into two groups. One group underwent GBR using acellular dermal matrix film combined with alveolar bone grafting using iliac crest bone grafts (GBR group), while the other group underwent alveolar bone grafting only (non-GBR group). CBCT images were obtained at 1 week and at 3 months following the procedure. Using Simplant 11.04 software, the bone resorption rate was calculated and compared between the two groups. The bone resorption rate from 1 week to 3 months following bone grafting without the GBR technique was 36.50±5.04%, whereas the bone resorption rate using the GBR technique was 31.69±5.50% (P=0.017). The application of autogenous iliac bone combined with the GBR technique for alveolar bone grafting of alveolar cleft patients can reduce bone resorption and result in better osteogenesis.


Assuntos
Enxerto de Osso Alveolar , Processo Alveolar/diagnóstico por imagem , Fissura Palatina/cirurgia , Tomografia Computadorizada de Feixe Cônico , Regeneração Tecidual Guiada Periodontal/métodos , Osteogênese , Processo Alveolar/anormalidades , Regeneração Óssea , Fissura Palatina/diagnóstico por imagem , Humanos , Estudos Prospectivos
10.
Am J Orthod Dentofacial Orthop ; 147(6): 766-80, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26038081

RESUMO

Aggressive periodontitis is a great challenge to clinicians when providing orthodontic treatment because of the potential for progression of periodontal disease. In this article, we report the successful comprehensive orthodontic treatment of bimaxillary protrusion and severe crowding in an adult with generalized aggressive periodontitis. A woman, aged 22 years 7 months, with a chief complaint of incisal crowding was diagnosed with a skeletal Class I malocclusion associated with severe anterior crowding, possibly worsened by generalized aggressive periodontitis. In addition to a periodontal examination, a blood IgG antibody titer analysis and microbiologic examination for periodontal pathogens were used to diagnose the type of periodontal disease and determine the proper timing to initiate orthodontic treatment. The total active treatment period was 28 months, followed by periodontal prostheses and regeneration therapy. Consequently, satisfactory facial profile, occlusion, and periodontal health were maintained for at least 36 months. These results indicate that efficient screening is important for providing successful orthodontic treatment in patients with advanced periodontal disease. This report also demonstrates the diagnostic importance of blood IgG antibody titer assays and microbiologic examinations to detect periodontal pathogens.


Assuntos
Periodontite Agressiva/terapia , Imunoglobulina G/sangue , Má Oclusão Classe I de Angle/terapia , Equipe de Assistência ao Paciente , Aggregatibacter actinomycetemcomitans/imunologia , Periodontite Agressiva/microbiologia , Perda do Osso Alveolar/terapia , Anticorpos Antibacterianos/sangue , Cefalometria/métodos , Feminino , Seguimentos , Regeneração Tecidual Guiada Periodontal/métodos , Humanos , Má Oclusão Classe I de Angle/sangue , Higiene Bucal , Planejamento de Assistência ao Paciente , Prótese Periodontal , Porphyromonas gingivalis/imunologia , Prevotella intermedia/imunologia , Fatores de Tempo , Técnicas de Movimentação Dentária/métodos , Resultado do Tratamento , Adulto Jovem
11.
J Periodontal Res ; 49(3): 333-45, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23841948

RESUMO

BACKGROUND AND OBJECTIVE: The complex microenvironment of the periodontal wound creates many challenges associated with multitissue regeneration of periodontal lesions. Recent characterization of mesenchymal stem cell-like populations residing in periodontal ligament tissues has shown that these cells exhibit features of postnatal stem cells. Despite these advances, a lack of consistency in design of preclinical studies and a limited study of allogeneic transplantation applications has restricted our understanding of their clinical utility in the treatment of periodontal disease. The aim of this study was to assess the regenerative potential of allogeneic periodontal ligament stem cells (PDLSCs) in a rat periodontal fenestration defect mode and to identify an optimal end time-point suitable for quantitative assessment of tissue regeneration. MATERIAL AND METHODS: Periodontal fenestration defects, created in Sprague Dawley rats, were treated with allogeneic PDLSCs seeded onto Gelfoam(®) (Absorbable gelatin sponge; Pharmacia Corporation, Kalamazoo, MI, USA) or with Gelfoam(®) alone, or remained untreated. Experimental rats were killed at 7, 14, 21 or 28 d after surgery and the tissues were processed for immunohistochemical and histomorphometric examination. RESULTS: Defects treated with PDLSCs showed significantly greater percentage bone fill and length of new bone bridge compared with the untreated group or the group treated with Gelfoam(®) alone on days 14 and 21. Similarly, a statistically significant difference was achieved within specimens retrieved on day 21 for analysis of regeneration of cementum/periodontal ligament (PDL)-like structures. CONCLUSION: The present investigation shows that allogeneic PDLSCs have a marked ability to repair periodontal defects by forming bone, PDL and cementum-like tissue in vivo. The results suggest that treatment periods of 14 and 21 d are optimal end time-points for quantitative assessment of periodontal regeneration within the rodent fenestration-defect model utilized in the present study.


Assuntos
Aloenxertos/transplante , Perda do Osso Alveolar/terapia , Ligamento Periodontal/citologia , Regeneração/fisiologia , Transplante de Células-Tronco/métodos , Processo Alveolar/patologia , Animais , Regeneração Óssea/fisiologia , Diferenciação Celular/fisiologia , Separação Celular/métodos , Cementogênese/fisiologia , Colágeno/ultraestrutura , Tecido Conjuntivo/patologia , Modelos Animais de Doenças , Feminino , Citometria de Fluxo , Esponja de Gelatina Absorvível/química , Regeneração Tecidual Guiada Periodontal/métodos , Osteogênese/fisiologia , Ligamento Periodontal/patologia , Ratos , Ratos Sprague-Dawley , Engenharia Tecidual/métodos , Alicerces Teciduais/química
12.
Quintessence Int ; 44(1): 75-84, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23444165

RESUMO

In clinical practice, dentists are faced with the dilemma of whether to treat, maintain, or extract a tooth. Of primary importance are the patient's desires and the restorability and periodontal condition of the tooth/teeth in question. Too often, clinicians extract teeth when endodontic therapy, crown-lengthening surgery, forced orthodontic eruption, or regenerative therapy can be used with predictable results. In addition, many clinicians do not consider the use of questionable teeth as provisional or transitional abutments. The aim of this article is to present a novel decision tree approach that will address the clinical deductive reasoning, based on the scientific literature and exemplified by selective case presentations, that may help clinicians make the right decision. Innovative decision tree algorithms will be proposed that consider endodontic, restorative, and periodontal assessments to improve and possibly eliminate erroneous decision making. Decision-based algorithms are dynamic and must be continually updated in accordance with new evidence-based studies.


Assuntos
Algoritmos , Tomada de Decisões , Árvores de Decisões , Planejamento de Assistência ao Paciente , Doenças Dentárias/terapia , Adulto , Fatores Etários , Perda do Osso Alveolar/terapia , Aumento da Coroa Clínica/métodos , Coroas , Implantes Dentários , Restauração Dentária Permanente/métodos , Prótese Parcial Fixa , Odontologia Baseada em Evidências , Feminino , Defeitos da Furca/terapia , Regeneração Tecidual Guiada Periodontal/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Extrusão Ortodôntica/métodos , Doenças Periodontais/terapia , Prognóstico , Tratamento do Canal Radicular/métodos , Extração Dentária/métodos , Desgaste dos Dentes/terapia , Dente não Vital/terapia
13.
Clin Implant Dent Relat Res ; 14(1): 112-20, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-20491815

RESUMO

BACKGROUND: Large osseous defects that fail to heal spontaneously require ridge augmentation prior to implant placement. The periosteum can act as an effective barrier membrane. Little is known about the influence of bone decortication in enhancing guided bone regeneration outcomes. PURPOSE: The aim of the present study was a clinical, tomographic, and histological evaluation of bone healing in large defect sites treated with cortical perforations without the use of other membranes but the periosteum. MATERIAL AND METHODS: Ten consecutive patients undergoing ridge augmentation on the pre-maxilla due to severe bone loss were followed for an average of 35 months. Recipient sites were cortico-perforated and augmented using a combination of autogenous particulate and block grafts. The periosteal membrane was preserved and it fully covered the autografts. Histological analysis was performed in four sites from a trephine core taken at the time of implant osteotomy preparation. Tomographic assessment (computed tomography [CT] scan) at baseline and post-augmentation evaluated graft volume maintenance. RESULTS: Recipient sites were re-entered for implant placement showing good incorporation of the grafts with minimal volume loss. Biopsy specimens showed viable bone rich in osteoblast-like cells with little or no inflammatory cells. Clinical exam revealed absence of implant transparency, mucosal recession, mobility, bleeding on probing, or suppuration at follow-up. CT scan evaluation showed an average increased bucco-lingual width at the recipient site of 8.1 mm ± 0.9 (2.5 fold) versus a 3.2 ± 0.9 at baseline (p < .0001; CI 95%: 4.04-5.71 mm), maintaining on average 98% of the augmented width at 2.9 years. CONCLUSIONS: Periosteal preservation seems to be sufficient as a barrier membrane to protect particulate or block osseous grafts provided that good primary closure is achieved. Bone decortication may enhance clinical and histological outcomes. Graft viability (biopsy specimens) and volume maintenance (CT evaluation) remained stable 35 months post-augmentation.


Assuntos
Aumento do Rebordo Alveolar/métodos , Regeneração Óssea , Regeneração Tecidual Guiada Periodontal/métodos , Maxila/cirurgia , Ligamento Periodontal/fisiologia , Periósteo/fisiologia , Adulto , Idoso , Perda do Osso Alveolar/patologia , Perda do Osso Alveolar/cirurgia , Transplante Ósseo/métodos , Implantação Dentária Endóssea , Prótese Dentária Fixada por Implante , Feminino , Seguimentos , Sobrevivência de Enxerto , Humanos , Masculino , Pessoa de Meia-Idade , Neovascularização Fisiológica , Estudos Prospectivos , Estatísticas não Paramétricas , Tomografia por Raios X
14.
Indian J Dent Res ; 22(3): 391-5, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22048577

RESUMO

AIMS: The purpose of the present study was to evaluate and compare the clinical outcome of infrabony defects following reconstructive surgery with the use of tricalcium phosphate (TCP) alone; TCP and citric acid (CA) root conditioning; and TCP, CA, and oxidized regenerated cellulose (ORC) membrane. MATERIALS AND METHODS: Thirty-nine systemically healthy subjects with vertical infrabony defect were initially selected based on intraoral periapical radiographs and clinical examination to record probing pocket depth (PPD) and clinical attachment level (CAL). Only 21 defects revealed two-walled configuration on surgical debridement. These defects were selected and randomly allotted to the study groups. Group 1 defects were treated with TCP, group 2 with TCP+CA, and group 3 with TCP+CA+ORC. PPD, CAL, defect depth (DD), and level of alveolar crest (AC) were evaluated at the time of initial surgery and after 6 months at surgical re-entry. These measurements were utilized to calculate PPD reduction, CAL gain, defect fill (DF), %defect fill (%DF), and crestal resorption (CR). STATISTICAL ANALYSIS: A paired t-test was used for assessing changes in each group. Unpaired t-test was used for intergroup comparisons. RESULTS: All three groups showed statistically significant PPD reduction, CAL gain, DF, and %DF, but insignificant CR at the end of 6 months. On intergroup comparison, no statistically significant differences were noted between the groups for all the parameters. CONCLUSION: Efficacy of combination techniques using TCP+CA; TCP+CA+ORC in treatment of periodontal infrabony defects is at least equal to that of TCP alone.


Assuntos
Perda do Osso Alveolar/terapia , Materiais Biocompatíveis/uso terapêutico , Fosfatos de Cálcio/uso terapêutico , Celulose Oxidada/uso terapêutico , Regeneração Tecidual Guiada Periodontal/métodos , Condicionamento de Tecido Mole Oral/métodos , Adulto , Regeneração Óssea/efeitos dos fármacos , Substitutos Ósseos/uso terapêutico , Ácido Cítrico/uso terapêutico , Terapia Combinada , Seguimentos , Humanos , Membranas Artificiais , Pessoa de Meia-Idade , Osseointegração/efeitos dos fármacos , Índice Periodontal , Resultado do Tratamento , Adulto Jovem
15.
Artigo em Inglês | MEDLINE | ID: mdl-21837309

RESUMO

The emergence of implant dentistry has led to the need for bone augmentation procedures. With the removal of a tooth, there is an inevitable three-dimensional (3D) loss of alveolar bone. More often than not, horizontal bone loss occurs at a faster rate and to a greater extent compared to vertical bone loss. This led to the development of several horizontal bone augmentation techniques, such as guided bone regeneration, ridge expansion, distraction osteogenesis, and block grafts. These proposed augmentation techniques aim to place the implant in an ideal 3D position for successful restorative therapy. The literature has shown that horizontal bone augmentation is fairly predictable if certain criteria are fulfilled. However, with numerous techniques and materials currently available, it is difficult to choose the most suitable treatment modality. A search of the literature available was conducted to validate the decision-making process when planning for a horizontal ridge augmentation procedure. The decision tree proposed in this paper stems from the 3D buccolingual bone width available at the site of implant placement (⋝ 3.5 mm, < 3.5 mm, or 4 to 5 mm). In each dimension, techniques are advised after considering factors such as the tissue thickness, the arch position, and the availability of autogenous bone. The decision tree provides insight on how clinicians can choose the most appropriate and predictable horizontal ridge augmentation procedure to minimize unnecessary complications.


Assuntos
Aumento do Rebordo Alveolar/métodos , Árvores de Decisões , Planejamento de Assistência ao Paciente , Perda do Osso Alveolar/classificação , Perda do Osso Alveolar/cirurgia , Processo Alveolar/patologia , Aumento do Rebordo Alveolar/classificação , Materiais Biocompatíveis/uso terapêutico , Substitutos Ósseos/uso terapêutico , Transplante Ósseo/classificação , Arco Dental/patologia , Implantação Dentária Endóssea/instrumentação , Implantes Dentários , Planejamento de Prótese Dentária , Regeneração Tecidual Guiada Periodontal/métodos , Humanos , Mandíbula/patologia , Mandíbula/cirurgia , Maxila/patologia , Maxila/cirurgia , Membranas Artificiais , Osteogênese por Distração/métodos , Resultado do Tratamento
16.
J Periodontol ; 81(3): 435-41, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-20192871

RESUMO

BACKGROUND: Minimally invasive surgery (MIS) is a surgical technique using very small incisions indicated for performing regenerative therapy in periodontal defects. The 11-month results from a prospective study of MIS were previously published. This article presents the 6-year results of that prospective study. METHODS: Patients from two private periodontal practices with advanced periodontitis who, after non-surgical therapy, had one or more sites with probing depths >or=6 mm were included in the study. An MIS surgical approach was used for all sites >or=6 mm. After surgical debridement, enamel matrix derivative (EMD) was placed into the bony defect. The surgical sites were reevaluated after >or=6 years. RESULTS: Six-year data were available on 142 sites in 13 patients. No significant differences were noted in the results between the two offices, and the data were combined. Probing depths (mean: 3.18 mm; SD: 0.59 mm) and attachment levels (mean: 3.93 mm; SD: 0.19) at 6 years were unchanged from the 11-month measurements. No recession from preoperative levels was noted. All sites continued to be considered clinically successful. CONCLUSIONS: The combination of MIS and EMD yielded significant reductions in probing depths and improvements in attachment levels while producing no detectable recession. The 11-month results remained stable at 6 years.


Assuntos
Perda do Osso Alveolar/cirurgia , Regeneração Óssea/efeitos dos fármacos , Substitutos Ósseos/farmacologia , Periodontite Crônica/cirurgia , Proteínas do Esmalte Dentário/farmacologia , Regeneração Tecidual Guiada Periodontal/métodos , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Idoso , Perda do Osso Alveolar/tratamento farmacológico , Perda do Osso Alveolar/etiologia , Substitutos Ósseos/uso terapêutico , Periodontite Crônica/complicações , Periodontite Crônica/tratamento farmacológico , Proteínas do Esmalte Dentário/uso terapêutico , Feminino , Seguimentos , Retração Gengival/prevenção & controle , Humanos , Masculino , Pessoa de Meia-Idade , Perda da Inserção Periodontal/tratamento farmacológico , Perda da Inserção Periodontal/cirurgia , Estudos Prospectivos
17.
J Oral Sci ; 51(3): 383-400, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19776505

RESUMO

In a 1998 review article, Laurell and colleagues performed a meta-analysis of relevant guided tissue regeneration (GTR) articles over the previous 20 years (1). The purpose of the present research was to expand on that work, particularly searching for trends discriminating between bioabsorbable and non-bioabsorbable barriers, as well as the use of enamel matrix derivative, with respect to interproximal bony defects. The most recent periodontal journals were reviewed and a search of PubMed (National Institutes of Health) was conducted via the internet covering 1990 to the present. Forty-nine articles were found to be relevant and within established parameters. The data were analyzed using (a) a variation of the methods described in Laurell et al. (1) and (b) statistics appropriate for inter-group comparisons. In most respects, all membranes and enamel matrix derivative (EMD) delivered better outcomes, in the range of 1 to 2 mm, than open flap debridement. The use of any barrier type or EMD configuration was found to yield more Clinical Attachment Level (CAL) gain than any open flap configuration. Other than collagen without grafts versus non-bioabsorbables without grafts, no other comparison between membranes or between membranes and EMD found any significant differences (P > 0.05). GTR was confirmed to be superior to open flap debridement.


Assuntos
Perda do Osso Alveolar/cirurgia , Regeneração Tecidual Guiada Periodontal/métodos , Membranas Artificiais , Implantes Absorvíveis , Regeneração Óssea/efeitos dos fármacos , Substitutos Ósseos , Transplante Ósseo , Desbridamento , Proteínas do Esmalte Dentário/farmacologia , Humanos , Politetrafluoretileno
18.
J Clin Periodontol ; 35(8 Suppl): 173-202, 2008 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-18724850

RESUMO

OBJECTIVE: To compare the clinical outcomes related to implants following lateral augmentation procedures (GBR, bone grafts, split osteotomy) with implants placed in pristine sites. MATERIAL AND METHODS: A systematic review of all prospective studies of implants placed simultaneously or as a second surgery following lateral augmentation compared with implants placed in pristine bone with 6 months of loading was performed. RESULTS: From 435 potentially relevant publications, 125 full-text publications were screened and four were identified as fulfilling the inclusion criteria. Three studies compared implants placed with simultaneous GBR or with a bone substitute and one with autogenous bone graft as a staged procedure. The implant survival at the augmented sites irrespective of the procedure used varied from 91.7% to 100% and from 93.2% to 100% at the control sites for a period between 12 and 59.1 months. CONCLUSIONS: Within the limits of the systematic review there was evidence that the evaluated augmentation techniques result in similar implant survival between augmented and pristine sites. The small number of retrieved studies fulfilling the inclusion criteria limited the conclusions regarding the success of the augmentation and its effect on the survival of the implants. Properly designed randomized controlled clinical trials on this topic are needed.


Assuntos
Aumento do Rebordo Alveolar/métodos , Transplante Ósseo , Implantes Dentários , Membranas Artificiais , Osteotomia/métodos , Aumento do Rebordo Alveolar/instrumentação , Substitutos Ósseos/uso terapêutico , Transplante Ósseo/métodos , Regeneração Tecidual Guiada Periodontal/métodos , Humanos , Estudos Prospectivos , Análise de Sobrevida , Resultado do Tratamento
19.
J Periodontol ; 79(7): 1133-40, 2008 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-18597594

RESUMO

BACKGROUND: Guided bone regeneration (GBR) is a widely used procedure for augmenting alveolar ridge width prior to placement of endosseous implants. Various graft materials and barrier membranes (non-resorbable and bioabsorbable) have been used in GBR. The aim of this study was to assess the performance of a new bioabsorbable, synthetic polyglycolic acid/trimethylene carbonate (PGA/TMC) barrier membrane with an increased absorption time in conjunction with a combination of assayed demineralized bone matrix and cortical cancellous chips uniformly dispersed in a thermoplastic biologic carrier. METHODS: At 72 potential implant sites in 38 subjects, ridge width at the crest and 4 mm apical to the crest was measured before and 6 months after a GBR procedure using the long-term (LT) PGA/TMC membrane and an allograft in a thermoplastic carrier. Before placement of endosseous implants, 48 biopsy specimens were obtained from the augmentation sites and analyzed histomorphometrically. RESULTS: The GBR procedure increased the mean ridge width at the crest from 2.4 to 5.2 mm. This 216% change from baseline was significant (P <0.001). The mean width 4 mm apical to the crest increased from 4.4 to 7.5 mm, a significant (P <0.001) 174% change. The histomorphometric analysis showed that the biopsy specimens consisted, on average, of 57% bone (36% graft material and 21% new bone) and 43% soft tissue and space. CONCLUSION: Our findings suggest that the LT PGA/TMC barrier membrane, used in conjunction with an allograft, provides lateral alveolar ridge augmentation comparable to that achieved with other materials without the necessity for bone-graft harvesting or a second procedure to remove the barrier membrane.


Assuntos
Implantes Absorvíveis , Processo Alveolar/patologia , Aumento do Rebordo Alveolar/métodos , Transplante Ósseo , Membranas Artificiais , Absorção , Adulto , Idoso , Aumento do Rebordo Alveolar/instrumentação , Biópsia , Matriz Óssea/transplante , Transplante Ósseo/patologia , Implantes Dentários , Dioxanos/química , Feminino , Seguimentos , Regeneração Tecidual Guiada Periodontal/métodos , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Osteogênese/fisiologia , Ácido Poliglicólico/química , Deiscência da Ferida Operatória/etiologia , Infecção da Ferida Cirúrgica/etiologia , Transplante Homólogo
20.
Dentomaxillofac Radiol ; 35(5): 371-5, 2006 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-16940486

RESUMO

OBJECTIVES: The main purpose of this study was to evaluate the radiographic aspect of the healing of extraction sockets filled with a xenogenic graft material (Gent-tech). METHODS: Thirty-nine patients ranging in age from 15 years to 25 years with bilateral impacted mandibular molars were chosen based on bilateral mandibular similarities. After tooth extraction, the socket was filled with the graft. The opposite site was left to heal naturally and served as a control. The experimental and control sites were chosen randomly. Bone density and crest healing were evaluated on digital radiographs taken immediately, 2 months and 6 months after surgery. The respective pixels values obtained with the Digora software were compared statistically. RESULTS: The results showed a significant decrease in the distance from the cemento-enamel junction to the alveolar bone crest, but no difference was found between the control and experimental groups. Bone density increased significantly, and there was difference between experimental and control groups. CONCLUSION: The analysed parameters observed by the authors were similar to those of the control group, suggesting xenogenic graft being an acceptable material and a graft option.


Assuntos
Proteínas Morfogenéticas Ósseas/farmacologia , Regeneração Óssea/efeitos dos fármacos , Substitutos Ósseos/farmacologia , Regeneração Tecidual Guiada Periodontal/métodos , Alvéolo Dental/diagnóstico por imagem , Implantes Absorvíveis , Adolescente , Adulto , Análise de Variância , Animais , Densidade Óssea , Transplante Ósseo , Bovinos , Durapatita , Feminino , Humanos , Masculino , Membranas Artificiais , Dente Serotino/cirurgia , Radiografia Dentária Digital , Extração Dentária , Alvéolo Dental/cirurgia , Cicatrização/efeitos dos fármacos
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