Clinical and laboratory assessment of the state of periapical tissues in systemic lupus erythematosus.

OBJECTIVE: Aim: To evaluate changes in clinical and laboratory parameters in patients with SLE depending on the severity and activity of the disease. PATIENTS AND METHODS: Materials and Methods: The study included 50 patients with SLE of different age groups, 10 men and 40 women. RESULTS: Results: Systemic lupus erythematosus (SLE) is a chronic disease that belongs to the group of rheumatic diseases and is characterised by autoimmune tissue damage. Chronic inflammatory periodontal diseases remain one of the most common dental pathologies. Chronic gingivitis and periodontitis in SLE are described as one of the earliest and most striking symptoms of the disease. Approximately the same trend was found in patients with SLE depending on the degree of clinical and laboratory activity of the disease. Patients with minimal, 1 degree of activity (characterized by the longest duration of SLE) showed the greatest decrease in bone mineral density (up to 2.25 points), and patients with higher activity had a significantly shorter duration of SLE and, accordingly, a smaller decrease in bone mineral density: in patients with 2 degrees of activity (1.79 points), with 3 degrees of activity (1.94 points). CONCLUSION: Conclusions: In patients with acute SLE, the maximum value of the Muhlemann-Cowell index was 2.31 points, in patients with subacute SLE - 1.89 points, and in patients with chronic SLE - 1.58 points. CPITN values increase inversely with the nature of the course of SLE, which is associated with the duration of the underlying disease.

Histological assessment of human regenerative endodontic procedures (REP) of immature permanent teeth with necrotic pulp/apical periodontitis: A systematic review.

The aim of this study was to systematically review the histological evidence of the neo-formed tissues inside the root canals of human teeth having previously received regenerative endodontic treatment. An electronic research was performed in the MEDLINE, Web of Science, Scopus and Cochrane Library databases using controlled vocabulary. The retrieved studies were screened by two reviewers according to the predetermined inclusion and extrusion criteria and were full-text-evaluated. Research resulted in 160 studies. Among them, twelve fitted the inclusion criteria and were critically appraised. The tissues formed in the root canals of immature human teeth treated with REP indicate repair or a combination of repair and regeneration. Pulp remnants and healthy periapical tissues seem to improve regeneration. The level of available evidence was low. Further clinical studies are needed in order to establish the appropriate treatment protocol related to the pretreatment status of the dental pulp and the periapical tissues.

A retrospective analysis of hospitalisation for diseases of the pulp and periapical tissues in NHS Grampian 2011-2015: geographic, socioeconomic and increased primary care availability effects.

Objectives A study of hospital admissions for diseases of pulp and periapical tissues in NHS Grampian and the effects of socioeconomic, geographic location and primary dental care availability on hospital admissions.Design Retrospective analysis of hospitalisation data from NHS Grampian Health Intelligence database for the five-year period (1 January 2011 to 31 December 2015), if their primary diagnosis was disease of the pulp or periapical tissues. The influence of the Scottish Index of Multiple Deprivation (SIMD) scores on hospital admissions for pulp or periapical diseases were assessed and compared. Data from general dental practitioners (GDPs) providing primary care were obtained from the National Services Scotland practitioner services board.Results There were 963 admissions to NHS Grampian hospitals over the five-year period. The most frequent hospitalisation admission code was K047 'periapical abscess without sinus', accounting for 59.3% of all admissions. Hospital admissions decreased from 185 in 2011 to 122 in 2015, and coincided with a 50% rise in the number of GDPs providing primary care dentistry within the region (171 in 2011 to 256 in 2015). SIMD 5 (least deprived) had the greatest number of admissions (68) in 2011 compared with the most deprived (11). In 2015, SIMD 4 had the most admissions (41) compared to SIMD 1 (12).Conclusion A reduction in hospital admissions for pulp/periapical abscesses appears to coincide with an increase in GDPs providing primary care dental services. Barriers to providing dental treatment in primary care should be minimised to reduce the burden of care on NHS hospitals for preventable dental diseases such as periapical abscesses.

[Endodontic re-treatment or apical surgery, is an evidence-based choice possible?]. / Endodontische herbehandeling of apexresectie: is een evidencebased keuze mogelijk?

Treatment of a recurrence after an initial endodontic treatment can consist of endodontic re-treatment or apical surgery. The literature reports comparable success rates for these two options. However, randomised controlled trials that are truly comparable to each other are unavailable as a result of which comparison and an informed choice are not really possible. In addition to the treatment outcome, consideration also has to be given to cost-effectiveness and other patient-related factors, such as pain, swelling and medication. Regarding these considerations, too, little reliable information can be found in the literature. Moreover, factors relating to insurance play an important role in the Netherlands, where only apical surgery is covered by the basic healthcare insurance. In conclusion, all of these factors should be carefully considered before proceeding to an individual treatment strategy.

Agreement between 2D and 3D radiographic outcome assessment one year after periapical surgery.

AIM: To compare 2D with 3D radiography in assessing the treatment outcome 1 year after periapical surgery. METHODOLOGY: In this prospective study, periapical radiographs (PA) and cone beam computed tomography (CBCT) were performed 1 year after periapical surgery. Three calibrated observers independently evaluated the radiographs for the presence and type of periapical radiolucencies. Ratings in PA were compared to those in bucco-lingual and mesio-distal CBCT images (coronal and sagittal planes), and the ratings of the latter two were also compared between each other. Further, maximum size diameters of radiolucencies were measured on CBCT scans, and the calculated means were correlated with the types of radiolucency. Statistical analysis was completed using Friedman rank sum tests, the Wilcoxon signed rank test and the Pearson correlation coefficient. RESULTS: A total of 61 roots in 54 patients were eligible for the final assessment. On average, the intra-observer ratings were identical in 59.6% when comparing PA and CBCT (kappa 0.112 to 0.192). A very high intra-observer agreement (93.4%) was noted when comparing bucco-lingual and mesio-distal CBCT ratings (kappa 0.797 to 1). Interobserver agreement was higher for PA (68.8%) than for CBCT (bucco-lingual 45.9%, mesio-distal 47.5%), but without reaching significant differences. The calculated mean size of persistent radiolucencies in CBCT scans correlated well with the assigned types of radiolucency. CONCLUSION: CBCT images showed in nearly a third of the evaluated cases a worse situation than PA. There is a need to define criteria to assess the 'radiographic healing' in CBCT following periapical surgery.

Assessment of Apical Expression of Alpha-2 Integrin, Heat Shock Protein, and Proinflammatory and Immunoregulatory Cytokines in Response to Endodontic Infection.

INTRODUCTION: The purpose of this study was to examine alpha-2 integrin, molecular mediators, cytokines, and chemokines from cells in periapical interstitial fluid from root canal infections before and after the reduction of the bacterial load using a cleaning procedure. METHODS: Subjects included 20 patients referred to the School of Dentistry at the Universidade Federal de Minas Gerais (Belo Horizonte, Minas Gerais, Brazil). Clinical samples were taken from teeth with pulp necrosis, and no patients had acute periapical symptoms at the time of the appointments. After cleaning and drying, 3 paper points were introduced into the root canal, passing passively through the root apex (2 mm) into the periapical tissues for 1 minute. The samples were collected immediately after root canal cleaning and 7 days later (restrained root canal bacterial load) to characterize those gene expressions using real-time polymerase chain reaction. RESULTS: Significantly lower levels of tumor necrosis factor alpha, chemokine ligand 5 (CCL5), chemokine ligand 2/monocyte chemotactic protein 1 (CCL2/MCP-1), and interleukin (IL)-8 in teeth with restrained bacterial loads (second collection) compared with the first collection were observed (P < .05). Similarly, the messenger RNA expression of the integrins secreted phosphoprotein 1 (SSP1)/ostepontin and focal adhesion kinase (FAK) decreased in samples from the second collection (P < .05). The messenger RNA for the regulatory cytokine IL-10 was significant higher in samples from the second collection (day 7) compared with the first collection (day 0) (P < .05). Messenger RNA expression of IL-1ß, IL-17A, interferon gamma, alpha-2 integrin, and Hsp47/SERPINH1 were similar at both time points (P > .05). CONCLUSIONS: These findings suggest that after reducing the root canal bacterial load a decrease in the inflammatory response took place in the periapical lesions.

Clinical and radiographic assessment of the efficacy of calcium silicate indirect pulp capping: a randomized controlled clinical trial.

The aims of this study were to assess the effectiveness of calcium silicate cement (Biodentine) versus glass ionomer cement (GIC; control group) as indirect pulp capping materials in patients with reversible pulpitis and to compare the effectiveness of cone beam computed tomography (CBCT) versus periapical (PA) radiographs in detecting PA changes at baseline (T0) and at 12 mo (T12) postoperatively. Seventy-two restorations (36 Biodentine, 36 Fuji IX) were placed randomly in 53 patients. CBCT/PA radiographs were taken at T0 and T12. Two calibrated examiners assessed the presence/absence and increase/decrease in the size of existing PA radiolucencies under standardized conditions. The Kappa coefficient evaluated statistically the effectiveness of CBCT versus PA radiographs in detecting PA changes. Chi-square/Mann-Whitney tests were used to evaluate the association between PA changes in CBCT with various clinical measures. Significance was predetermined at α = 0.05. Clinical success rates for Biodentine and Fuji IX GIC were 83.3%. CBCT was significantly more effective in detecting PA radiolucencies compared with radiographs (P = 0.0069). Of the teeth, 65.4% and 90.4% were deemed healthy using CBCT and PA radiographs, respectively, at T12. Healing/healed rates were 17.3%/0%, while new/progressed radiolucency were 30.8%/9.6% with CBCT/PA radiographs, respectively. Seventy-one percent of healed lesions had received Biodentine; 88% of new/progressed lesions received Fuji IX GIC. Teeth presenting with an initial CBCT PA lesion had a failure rate of 63%, whereas teeth with no initial lesion had a failure rate of 16%. Although no statistically significant difference was detected in the clinical efficacy of Biodentine/Fuji IX when used as indirect pulp capping materials in patients with reversible pulpitis, CBCT showed a significant difference in that most healed CBCT lesions had received Biodentine while most that did not heal received Fuji IX. Longer-term follow-up is needed to establish their effect on the healing dynamics of PA tissues (ClinicalTrials.gov NCT02201641).

Radiographic assessment of the technical quality and periapical health of root-filled teeth performed by general practitioners in a Turkish subpopulation.

AIM: The aim of this study was to evaluate by means of radiographs the technical quality of root fillings performed by dental practitioners. METHODS AND MATERIAL: Standardized periapical radiographs were made on 484 patients who received endodontic treatment in private practice. A total of 831 endodontically treated teeth with 1448 roots were evaluated for technical quality of the root canal filling and the periapical status of the teeth. Also, the apical status of each root-filled tooth was assessed according to the length, density, and taper of root fillings, and the presence of apical transportation, broken root instruments, and overfilled sealer or gutta-percha material was recorded for each root canal. RESULTS: Of the endodontically treated teeth 26.6% had healthy periapical tissues, while technically good endodontic treatment constituted 12.8%. Based on the treatment success, there was no significant difference between the tooth groups. Statistical analysis of the data did not demonstrate statistically significant differences between the various parameters that were evaluated (P < 0.05). CONCLUSIONS: Technical quality of root fillings in a population who received treatment in private practice was poor and was consistent with a low prevalence of apical health. The probable reasons for this failure are multifactorial and may be improved if the operators improve their skills with continuing postgraduate education programs.

Histologic and histomorphometric assessment of implants and periapical tissues when placed in the sockets of extracted teeth, teeth with periapical lesions, and healed lesions: a canine study.

Eighteen canine mandibular premolars were divided into 3 groups. In group 1, implants were inserted in periapical lesions. In group 2, implants were inserted when lesions were radiographically healed. In group 3 (control), implants were inserted immediately after extraction. There was no significant difference in average bone implant contact between the 3 groups. Considering the limitations of this study, immediate placement of dental implants in tooth sockets with periapical lesions should be proposed only under special circumstances.

Retrospective radiological assessment of root canal treatment in young permanent dentition in a Turkish subpopulation.

AIM: To determine the technical quality of root fillings as well as the periapical status of root filled teeth and non-root filled teeth in young permanent dentitions using a retrospective analysis of orthopantomographs (OPTGs) in a Turkish subpopulation. METHODOLOGY: Included in this study were the digital OPTGs taken as a part of diagnostic and planning procedures for all 19-year-old adolescents who attended the Faculty of Dentistry, Marmara University (Istanbul, Turkey) for the first time during the period from June 2007 to May 2009. The periapical status of all teeth and the technical quality of the root fillings were assessed by radiographic criteria. Statistical analysis was performed by the Mann-Whitney U, chi-squared, Fisher's exact and Cohen's kappa tests. RESULTS: The survey involved OPTGs of 1077 19-year-old adolescents: 663 (61.6%) women and 414 (38.4%) men. Of the 28974 teeth examined, 459 (1.6%) were root filled, of which 193 (42.0%) had radiological signs of apical periodontitis (AP), and 454 (1.6%) were non-root filled teeth with AP. No significant difference was found between women and men regarding the number of teeth present, the number of root filled teeth and the number of non-root filled teeth with AP (P>0.05). The most commonly treated teeth were molars (54.2%), followed by pre-molars (27.0%) and incisors (18.8%). Length was adequate in 57.3%, and homogeneity was adequate in 50.5% of the root fillings. Statistically, both the length and the homogeneity of the root fillings were significantly associated with periapical status individually (P<0.01). The overall technical quality was inadequate in 60.1% of the root fillings, and 67.0% of these were associated with signs of AP. Amongst root filled teeth, the frequency of AP in connection with molars was significantly higher (57.0%) than that for incisors (27.9%) and pre-molars (21.8%) (P<0.01). CONCLUSIONS: The results of this study indicated that the frequency of root filled teeth with AP, non-root filled teeth with AP and of technically inadequate root fillings amongst all root filled teeth was high in this selected adolescent Turkish population.

Assessment of periapical status: a comparative study using film-based periapical radiographs and digital panoramic images.

AIM: To compare the use of film-based periapical radiographs and digital panoramic images displayed on monitor and glossy paper in the assessment of the periapical status of the teeth. METHODOLOGY: A total of 86 subjects were examined. All participants underwent a full-mouth radiographic survey (14 periapical radiographs) and a digital panoramic radiography. The periapical status of all appraised teeth was assessed. RESULTS: Periapical radiographs allowed the assessment of the periapical status of a significantly higher percentage of teeth (87.4%) Digital radiography had a significantly reduced potential to allow assessment of the periapical status (p<0.01). Only 58.0% and 34.3% of teeth could be appraised using digital panoramic images displayed on monitor and glossy paper respectively (p<0.01). The total percentage of teeth with periapical pathosis was four-fold higher when assessed with digital panoramic images displayed on glossy paper compared with periapical radiographs (p<0.01). CONCLUSIONS: Periapical radiographs allowed the assessment of a significantly higher percentage of teeth when comparing to digital radiography, which had a significantly lower potency in the assessment of periapical status of the teeth. Digital panoramic images displayed on a monitor resulted in a significantly higher percentage of appraised teeth compared to digital images displayed on glossy paper. Apical periodontitis was scored more often on paper than on screen, and more often on screen than in periapical radiographs.

Periapical radiography and cone beam computed tomography for assessment of the periapical bone defect 1 week and 12 months after root-end resection.

OBJECTIVES: Our aim was to compare periapical radiography and cone beam CT (CBCT) for assessment of the periapical bone defect 1 week and 12 months after root-end resection. METHODS: 50 patients (58 teeth) with a persisting apical periodontitis in a root-filled tooth (incisor, canine or premolar) were treated with root-end resection. 1 week and 12 months post-operatively, a CBCT scan (NewTom 3G) and a periapical radiograph (Digora) were obtained. Three observers detected and measured the periapical bone defects on periapical radiographs and CBCT images (coronal and sagittal sections). RESULTS: 1 week post-operatively, a periapical bone defect area was measured in all teeth by all observers. The defect was 10% smaller on periapical radiographs (mean = 12.4 mm2, SD = 8.2) than on the CBCT images measured in the coronal plane (mean = 13.0 mm2, SD = 7.8), a difference which was not statistically significant (P = 0.58). 12 months post-operatively (n = 52), there was considerable variation between the observers' detection of a remaining defect on the periapical radiographs and the CBCT images. The average agreement between the periapical radiograph and the CBCT images in the coronal sections was 67%, and more defects were detected on CBCT than on periapical radiographs. CONCLUSIONS: On average, the periapical bone defect measured on periapical radiographs was approximately 10% smaller than on coronally sectioned CBCT images 1 week post-operatively. More remaining defects were detected 1 year after periapical surgery on CBCT images than on periapical radiographs, but it is uncertain how this information is related to success or failure after root-end resection.

Avaliação radiográfica periapical dos níveis de reabsorção radicular de incisivos superiores após tratamento ortodôntico / Periapical radiographical assessment of superior incisors' root reabsorption levels after orthodontic treatment

Neste trabalho foram avaliados os níveis de reabsorções radiculares apicais externas em decorrência da movimentação ortodôntica e a sua relação com as formas das raízes, gênero e tratamento com e sem extração de quatro premolares. A amostra utilizada foi composta de 47 pacientes, sendo 22 do gênero masculino e 25 do gênero feminino, com idade variando entre 9 e 29 anos. Foram utilizadas radiografias periapicais de incisivos superiores, obtidas antes e após o tratamento ortodôntico. Os pacientes foram tratados através da técnica stright wire e edgewise, por professores e alunos do curso de especialização em ortodontia e ortopedia facial da Universidade Vale do Rio Verde de Três Corações. Para avaliação dos níveis de reabsorção radicular externa e da forma radicular indizidas pela movimentação ortodôntica foi utilizada a classificação de Levander e Malmgren (1988) e Consolaro (2002). A análise estatística dos dados foi realizada utilizando-se o teste de mann-whitney (p<0,05). Através dos resultados pôde-se verificar que a reabsorção radicular apical externa ocorreu em 100 por cento dos casos, apresentando níveis variados. Os incisivos centrais e laterais superiores não apresentaram diferenças significativas entre si quanto à severidade de reabsroções radiculares. Dentes com raízes de forma abaulada ou romboidal, pacientes do gênero feminino e casos tratados com extrações de premolares apresentaram, significativamente, maior reabsorção radicular apical externa ao final do tratamento ortodôntico.

Patient characteristics associated with receipt of dental radiographic procedures during a 48-month population-based study of dentate adults.

OBJECTIVE: The objective was to test hypotheses that patient characteristics are associated with receipt of specific types of radiographic procedures. STUDY DESIGN: The Florida Dental Care Study was a prospective cohort study of dentate adults. RESULTS: From 19% to 59% of participants received a full-mouth series, panoramic, bitewing, or periapical radiograph(s), depending on procedure type. Receipt varied with reason(s) for dental visit(s), baseline clinical condition, race, approach to care (problem-oriented or regular dental attender), and socioeconomic status. CONCLUSION: These findings underscore the distinction between what dentists hypothetically would prescribe, compared to what is actually received, receipt that results from the interaction between dentist recommendations and what patients will accept and pay for. Blacks and lower-income persons received dental radiograph types that were consistent with less comprehensive dental treatment, even with entry into the dental care system, reason(s) for incident dental visit(s), baseline clinical status, and regular versus problem-oriented attendance taken into account.

Intra-oral storage phosphor and conventional radiography in the assessment of alveolar bone structures.

OBJECTIVES: To compare storage phosphor (SP) with conventional film radiography for accuracy of linear measurements of the marginal alveolar bone and visibility of anatomical structures. METHODS: Linear measurements were made in paired SP and conventional images of dried human mandibles with a metal pin fixed 10 mm below the alveolar crest. One observer measured the distance from the alveolar crest to the reference point on the radiographs. The difference between the measured and the true distance was calculated. Two observers rated the visibility of bony structures (periodontal ligament space, periapical bone tissue, alveolar crest) in 51 paired digital and conventional images of 21 patients on a 3-point scale. Overall agreement and Kappa index were calculated. RESULTS: Accuracy of linear measurements was higher in digital radiography (mean difference 0.17 mm) than in conventional radiography (mean difference 0.59 mm). Overall, the two observers rated visibility higher in conventional radiographs. The Kappa indices for the periodontal ligament space and periapical bone indicated fair to almost perfect agreement (kappa = 0.38 and 0.5; kappa = 0.39 and 0.84) while for the alveolar crest there was only poor or moderate agreement (kappa = 0.2 and 0.5). CONCLUSIONS: The small differences in linear measurements indicate that the Digora system is suitable for clinical assessment of periodontal and peri-implant bone loss. The visibility of dental structures depends as much on the individual features assessed, as the radiographic system.

Avaliação radiográfica de lesões periapicais / Periapical lesions radiographic assessment

Objetivo: Avaliar a concordância substancial inter-observadores e intra-observador na interpretação de radiografias periapicais de controle de tratamento endodôntico, analisando-se a evolução de lesões periapicais. Material e Métodos: O material consistiu de 40 radiografias periapicais (radiografia do pós-operatório imediato e radiografia de controle) de 20 tratamentos endodônticos realizados na Universidade de Pernambuco. Seis alunos do Curso de Especialização em Endodontia foram questionados para avaliar as radiografias dos 20 dentes e para responder um questionário com relação aos referidos casos. O mesmo procedimento foi repetido após uma semana com as mesmas radiografias, de forma aleatória, sem obedecer a mesma ordem, com o objetivo de verificar a variabilidade intra-examinador. A análise das radiografias foi realizada em condições padronizadas e próprias para sua devida interpretação. Resultados: Na primeira avaliação registrou-se um percentual de 50,3 por cento de coincidências entre os examinadores e na segunda avaliação de 49,7 por cento. Quando analisada a concordância intra-examinador, observou-se uma média de 55 por cento, o que equivale a um coeficiente Kappa 0,40 (regular). Conclusão: A pouca experiência profissional dos examinadores determinou uma pequena concordância intra-examinador e inter-examinador

Radiographic detection and assessment of the periodontal endosseous defects.

AIMS: The aim of the present study was to investigate the potential of conventional radiography in detecting and accurately imaging periodontal endosseous (or osseous) defects when compared to surgical measurements. A further objective of the study was the selection of the most successful radiographic method for the assessment of endosseous defects. METHOD: Surgical measurements, during periodontal flap surgery, and radiographic measurements, from periapical and panoramic radiographs, were obtained from 5,072 proximal surfaces of 100 patients presenting with periodontitis. RESULTS: Statistical evaluation of the surgical and radiographic measurements revealed the following. (1) The ability of the radiographs to detect periodontal osseous defects was relatively low. (2) For periapical radiography, it depended, in descending order, on the depth and buccolingual width of the defect, the number of osseous walls and the jaw location. For panoramic radiography, it depended only on buccolingual width. (3) Osseous defects of small depth and/or small buccolingual width were the most difficult to detect radiographically. (4) Periapical radiography was more successful than panoramic in detecting osseous defects, and more accurate in assessing the defect dimensions (depth, mesiodistal width). (5) The difference in the defect detection ability between the 2 radiographic methods, the accuracy of the radiographic defect dimensions assessment as well as the degree of agreement between periapical and panoramic assessment depended on defect location and dimensions. CONCLUSIONS: Periapical radiography is superior to panoramic in detecting and accurately imaging periodontal osseous destruction.