Comparative Effectiveness Analysis of Complex Lower Extremity Reconstruction: Outcomes and Costs for Biologically Based, Local Tissue Rearrangement, and Free Flap Reconstruction.

BACKGROUND: Various surgical techniques exist for lower extremity reconstruction, but limited high-quality data exist to inform treatment strategies. Using multi-institutional data and rigorous matching, the authors evaluated the effectiveness and cost of three common surgical reconstructive modalities. METHODS: All adult subjects with lower extremity wounds who received bilayer wound matrix, local tissue rearrangement, or free flap reconstruction were retrospectively reviewed (from 2010 to 2017). Cohorts' comorbidities and wound characteristics were balanced. Graft success at 180 days was the primary outcome; readmissions, reoperations, and costs were secondary outcomes. RESULTS: Five hundred one subjects (166 matrix, 190 rearrangement, and 145 free flap patients) were evaluated. Matched subjects (n = 312; 104/group) were analyzed. Reconstruction success at 180 days for matrix, local tissue rearrangement, and free flaps was 69.2 percent, 91.3 percent, and 93.3 percent (p < 0.001), and total costs per subject were $34,877, $35,220, and $53,492 (p < 0.001), respectively. Median length of stay was at least 2 days longer for free flaps (p < 0.0001). Readmissions and reoperations were greater for free flaps. Local tissue rearrangement, if achievable, provided success at low cost. Free flaps were effective with large, traumatic wounds but at higher costs and longer length of stay. Matrices successfully treated older, obese patients without exposed bone. CONCLUSIONS: Lower extremity reconstruction can be performed effectively using multiple modalities with varying degrees of success and costs. Local tissue rearrangement and free flaps demonstrate success rates greater than 90 percent. Bilayer wound matrix-based reconstruction effectively treats a distinct patient population. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.

Avaliação da sensibilidade em áreas de enxerto cutâneo do membro superior de pacientes queimados e sua repercussão na qualidade de vida / Assessment of skin graft areas sensibility of upper limb of burned patients and its repercussion on quality of life

OBJETIVO: Avaliar a sensibilidade de áreas que receberam enxerto de pele nos membros superiores de pacientes queimados e sua percepção de como a sensibilidade está relacionada à sua qualidade de vida. MÉTODO: Foram avaliados 30 indivíduos, com queimadura em membro superior, tratados com enxertia. Foram obtidos dados pessoais e histórico da lesão. Aplicava-se a escala de Vancouver para avaliar a sensibilidade da área enxertada e a mesma era medida. A sensibilidade tátil foi avaliada por meio de um estesiômetro, já a sensibilidade térmica foi avaliada por meio de um tubo de ensaio com água a 40°C, com água temperatura ambiente e aplicava-se gelo. Por meio da utilização do TENS, no modo convencional e com variação de intensidade e frequência (VIF), avaliou-se a sensação de prurido e sensibilidade nociceptiva, respectivamente. A qualidade de vida foi avaliada através do BSHS-R. RESULTADOS E CONCLUSÃO: Queimaduras nos membros superiores tratadas com enxerto de pele precisam de estímulos de intensidades maiores para despertar sensação nas áreas queimadas quando comparadas às sadias. A sensibilidade térmica tende a retornar mais rápido. As alterações da sensibilidade na área do enxerto interferem na qualidade de vida do paciente.

OBJECTIVE: To evaluate the sensitivity of areas that received skin grafts on the upper limbs of burned patients and their perception of how the sensitivity is related to their quality of life. METHODS: Thirty individuals with burns on the upper limbs, treated with grafting, were evaluated. Personal data and history of the injury were obtained. The Vancouver scale was applied to assess the sensitivity of the grafted area and it was measured. The tactile sensitivity was assessed by means of a stoichiometer, whereas the thermal sensitivity was assessed by means of a test tube with water at 40°C, with water at room temperature and ice was applied. Through the use of TENS, in the conventional way and with varying intensity and frequency (VIF), itching sensation and nociceptive sensitivity were evaluated, respectively. Quality of life was assessed using the BSHS-R. RESULTS AND CONCLUSION: Burns in the upper limbs treated with a skin graft need stimuli of greater intensity to arouse sensations when compared to healthy areas. Thermal sensitivity tends to return faster. Sensitivity changes in the graft area interfere with patients quality of life.

In vitro skin expansion: Wound healing assessment.

For treatments requiring split-thickness skin grafts, it is preferable to mesh the grafts. This reduces the amount of excised skin and covers more wound area. The mesh technique, however, destroys surface continuity, which results in scarring. Strain-based bioreactors, on the other hand, have successfully expanded split-thickness skin grafts in vitro within a 7-day period, increasing graft coverage. After in vitro expansion, the expanded skin grafts were tested in a porcine full-thickness excisional wound model. Expanded graft take rate was 100%. Volumetric, histologic, and mechanical assessments indicated that expanded grafts were comparable to unexpanded grafts (positive control). While there was considerable variation in expansion (31% to -3.1%), this technique has the potential to enhance the coverage area of skin grafts while reducing or eliminating scarring.

Comparison of commonly used mesher types in burns surgery revisited.

Meshed skin grafts are commonly used in the treatment of burns. Machines for meshing skin are expensive and therefore choosing the correct machine is important. We describe the two available groups of meshers, those that use carriers and those that do not, with advantages and disadvantages of each group. A cost comparison of the use of each type of mesher has been formulated. This information should aid the purchasers in making a more informed choice.

Experience with the modified Meek technique.

In 1958 Meek described the so called Meek-Wall dermatome to cut postage stamp skin grafts. This method was eclipsed by the introduction of mesh skin grafts. In 1993 Kreis and colleagues reintroduced a modified Meek technique using a dermatome running on compressed air. This technique has been used in our burn unit since August 1994. The aim of this paper is to compare the modified Meek technique with the mesh graft technique. Within a period of 20 months 41 patients were grafted using the modified Meek technique. The mean TBSAB was 54.4% with 50.0% full thickness burns. All patients were excised early. The expansion ratio was 1:4 and 1:6. In 20 patients the Meek technique was used exclusively for grafting of the trunk and the extremities with the exception of face, neck and hands. In 3 patients with a mean TBSAB of 68.3% a combination of postage stamp autologous skin grafts and cultured epithelial autografts (CEA) was applied. Compared with the mesh graft technique the Meek technique showed the following advantages: 1. The Meek method provides the true expansion ratio. 2. Small graft remnants can be utilized. 3. Grafting of full thickness burns up to 70 to 75% TBSAB becomes possible with one harvest of the donor sites. 4. The reliability of graft take is equal or better. 5. Epithelialization is achieved within 3 to 4 weeks depending on the expansion ratio. 6. The combination of widely expanded postage stamp split thickness grafts and CEA provides an excellent take rate and durable wound closure within a short time and avoids the problems associated with the engraftment of CEA on fascia. The method is simple but more demanding than the mesh technique. Compared with the mesh graft technique the preparation of Meek grafts is more time consuming and requires more staff than the Mesh technique. The cost of materials is higher. In our experience complete coverage of the Meek grafts with an overlay of meshed allografts after removal of the gauze as recommended by Kreis is not necessary using the 1:4 expansion ratio. Greater expansion ratios necessitate an overlay with meshed allografts. Regarding the scar formation no significant differences were observed compared with the mesh graft technique. In conclusion the modified Meek technique is reliable and simple to perform. This technique provides a sufficient expansion ratio enabling to graft patients with burns up to 75% TBSA with only one harvest of donor sides and without the necessity of CEA. In our opinion the Meek technique is reliable and simple to perform. This technique provides a sufficient expansion ratio enabling to graft patients with burns up to 75% TBSA with only one harvest of donor sides and without the necessity of CEA. In our opinion the Meek technique is advantageous in patients with burns greater than 45% TBSAB. In smaller burns mesh grafts should be used because of lower material cost and staff requirements. Especially in extensively burned patients the Meek technique may be cost effective avoiding the need of CEA.

Initial experience of using GRAFTAC absorbable staples to attach split skin grafts.

The GRAFTAC skin stapler with absorbable tacs has been used to attach split-skin grafts in 28 patients, under a variety of clinical situations, and the outcomes studied. This knowledge has been reviewed in the light of our existing experience with the more familiar metal staple. Details of the patients and their conditions are presented, with two illustrative case histories, including one where both Graftac and metal staples were used. The relative costs were analysed and an attempt made to compare the cost-effectiveness of tacs and staples. A rationale for use of the more expensive GRAFTAC stapler is presented.

Comparative clinical study of the sure-closure device with conventional wound closure techniques.

The Sure-Closure device, designed for wound closure, harnesses the viscoelastic properties of the skin. It has been used in clinical studies in the past. We have evaluated the role of this device in complex wound problems and compared it to closure achieved by conventional wound closure methods such as skin grafts and flaps. A total of 40 patients with multiple wound etiologies were examined. We used the device under local and general anesthesia. In addition, we performed cost analysis on the use of the device and compared this to traditional methods. We found a cost reduction trend associated with the Sure-Closure method (p < .05). All of the 24 patients in whom the device was used to close the wounds had complete primary closure. The device is also easy to use. When used for delayed stretching, as in some of our patients, the compliance rate was high.

New economical skin graft expansion wheel.

A simple and economical mesh graft expansion wheel is described. The instrument does not need any consumables--carriers for example--and is very low priced compared with other expanders. A small institution or a private practising surgeon in this country can afford it. It is possible to increase or reduce the number of wheels to individual surgeon's requirements. Different expansion ratios can be obtained by simple changes in design.