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2.
J Med Invest ; 67(1.2): 145-150, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32378598

RESUMO

Assessment of right ventricular (RV) function is quite important in patients with surgically corrected tetralogy of Fallot (TOF). However, quantitative assessment of RV function remains challenging, mainly because of the complex RV geometry. This prospective study investigated isovolumic acceleration (IVA), a parameter of myocardial systolic function not influenced by either preload or afterload, using tissue Doppler imaging. We evaluated IVA measured on pulmonary annulus (PA-IVA) and tricuspid annulus (TA-IVA), because we considered that PA-IVA and TA-IVA correspond with systolic function of the RV outflow tract (RVOT) and RV basal function, respectively. Thirty-nine patients with surgically repaired TOF (TOF group) and 40 age-matched healthy children (control group) were enrolled in this study. No significant difference was seen between TA-IVA (2.5 ±â€…0.8 m/s2) and PA-IVA (2.4 ±â€…0.8 m/s2) in the control group. In the TOF group, PA-IVA (1.0 ±â€…0.5 m/s2) was significantly lower than TA-IVA (1.3 ±â€…0.6 m/s2, p < 0.05). Both TA-IVA and PA-IVA were significantly lower in the TOF group than in the control group (p < 0.05 each). We concluded that PA-IVA offers a useful index to assess RVOT function in TOF patients. J. Med. Invest. 67 : 145-150, February, 2020.


Assuntos
Valva Pulmonar/fisiopatologia , Sístole/fisiologia , Tetralogia de Fallot/cirurgia , Valva Tricúspide/fisiopatologia , Função Ventricular Direita/fisiologia , Aceleração , Adolescente , Criança , Feminino , Humanos , Masculino , Estudos Prospectivos , Tetralogia de Fallot/fisiopatologia
3.
Int J Cardiovasc Imaging ; 35(8): 1453-1463, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30937683

RESUMO

To compare contrast-enhanced magnetic resonance angiography (ceMRA) and 3D steady-state free precession (SSFP) during systole and diastole for assessment of the right ventricle outflow tract (RVOT) in patients considered for percutaneous pulmonary valve implantation (PPVI) after tetralogy of Fallot (TOF) repair. We retrospectively evaluated 89 patients (male: 45, mean age 19 ± 8 years), who underwent cardiac-MRI after surgical TOF-repair. Datasets covering the whole heart in systole and diastole were acquired using ECG-gated 3D SSFP and non-gated ceMRA. Measurements were performed in SSFP-sequences and in ceMRA in the narrowest region of the RVOT to obtain the minimum, maximum and effective diameter. Invasive balloon sizing as the gold standard was available in 12 patients. The minimum diameter in diastolic SSFP, systolic SSFP and ceMRA were 21.4 mm (± 6.1 mm), 22.6 mm (± 6.2 mm) and 22.6 mm (± 6.0 mm), respectively. Maximum diameter was 29.9 mm (± 9.5 mm), 30.0 mm (± 7.0 mm) and 28.8 mm (± 8.1 mm) respectively. The effective diameter was 23.2 mm (± 5.7 mm), 27.4 mm (± 6.7 mm) and 24.4 mm (± 6.2 mm), differing significantly between diastole and systole (p < 0.0001). Measurements in ECG-gated SSFP showed a better inter- and intraobserver variability compared to measurements in non-ECG-gated ceMRA. Comparing invasive balloon sizing with our analysis, we found the highest correlation coefficients for the maximum and effective diameter measured in systolic SSFP (R = 0.99 respectively). ECG-gated 3D SSFP enables the identification and characterization of a potential landing zone for PPVI. The maximum and effective systolic diameter allow precise sizing for PPVI. Patients with TOF-repair could benefit from cardiac MRI before PPVI.


Assuntos
Cateterismo Cardíaco/métodos , Procedimentos Cirúrgicos Cardíacos , Implante de Prótese de Valva Cardíaca/métodos , Ventrículos do Coração/diagnóstico por imagem , Angiografia por Ressonância Magnética/métodos , Imageamento por Ressonância Magnética/métodos , Insuficiência da Valva Pulmonar/diagnóstico por imagem , Estenose da Valva Pulmonar/diagnóstico por imagem , Valva Pulmonar/diagnóstico por imagem , Tetralogia de Fallot/cirurgia , Adolescente , Adulto , Valvuloplastia com Balão , Cateterismo Cardíaco/instrumentação , Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Técnicas de Imagem de Sincronização Cardíaca , Criança , Meios de Contraste/administração & dosagem , Eletrocardiografia , Feminino , Próteses Valvulares Cardíacas , Implante de Prótese de Valva Cardíaca/instrumentação , Ventrículos do Coração/fisiopatologia , Humanos , Interpretação de Imagem Assistida por Computador , Imageamento Tridimensional , Masculino , Variações Dependentes do Observador , Valor Preditivo dos Testes , Desenho de Prótese , Valva Pulmonar/fisiopatologia , Valva Pulmonar/cirurgia , Insuficiência da Valva Pulmonar/etiologia , Insuficiência da Valva Pulmonar/fisiopatologia , Insuficiência da Valva Pulmonar/cirurgia , Estenose da Valva Pulmonar/etiologia , Estenose da Valva Pulmonar/fisiopatologia , Estenose da Valva Pulmonar/cirurgia , Reprodutibilidade dos Testes , Estudos Retrospectivos , Tetralogia de Fallot/diagnóstico por imagem , Tetralogia de Fallot/fisiopatologia , Resultado do Tratamento , Função Ventricular Direita , Adulto Jovem
4.
Cardiovasc Revasc Med ; 20(7): 553-558, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-30201480

RESUMO

BACKGROUND/PURPOSE: Percutaneous pulmonic valve implantation (PPVI) is an alternative treatment strategy to surgical pulmonic valve implantation (SPVI) for right ventricular outflow tract (RVOT) dysfunction. This study sought to compare outcomes of both treatment strategies. METHODS: The study population was extracted from the 2014 Nationwide Readmissions Database (NRD) using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes for PPVI and SPVI. Study outcomes included all-cause in-hospital mortality, length of index hospital stay (LOS), post-procedural bleeding, mechanical complications of heart valve prosthesis, vascular complications (VC), infective endocarditis (IE), total hospitalization charges, and 30-day readmission rates. RESULTS: A total of 975 patient discharges (176 in PPVI and 799 in SPVI group) were identified (average age 25.7 years; 57.5% male). PPVI was associated with significantly shorter median LOS (1 versus 5 days, p < 0.01), lower risk of bleeding (4.6% versus 26.4%, p < 0.01), and lower total hospitalization charges ($169,551.7 versus $210,681.8, p = 0.02). There was no significant difference between both groups in terms of all-cause in-hospital mortality (0% versus 1.4%, p = 0.12), mechanical complications of heart valve prosthesis (1.7% versus 2.0%, p = 0.78), VC (2.3% versus 2.0%, p = 0.82), IE (1.7% versus 3.1%, p = 0.31), or 30-day readmission rates (4.4% versus 7.6%, p = 0.16). CONCLUSION: Compared with SPVI, PPVI was associated with shorter LOS, lower bleeding, and lower total charges. There was no significant difference between the two strategies in terms of all-cause in-hospital mortality, mechanical complications of heart valve prosthesis, VC, IE, or 30-day readmission rates.


Assuntos
Cateterismo Cardíaco , Implante de Prótese de Valva Cardíaca , Insuficiência da Valva Pulmonar/cirurgia , Valva Pulmonar/cirurgia , Obstrução do Fluxo Ventricular Externo/cirurgia , Adolescente , Adulto , Cateterismo Cardíaco/efeitos adversos , Cateterismo Cardíaco/economia , Cateterismo Cardíaco/instrumentação , Cateterismo Cardíaco/mortalidade , Redução de Custos , Análise Custo-Benefício , Bases de Dados Factuais , Feminino , Próteses Valvulares Cardíacas , Implante de Prótese de Valva Cardíaca/efeitos adversos , Implante de Prótese de Valva Cardíaca/economia , Implante de Prótese de Valva Cardíaca/instrumentação , Implante de Prótese de Valva Cardíaca/mortalidade , Hemodinâmica , Preços Hospitalares , Mortalidade Hospitalar , Humanos , Tempo de Internação , Masculino , Readmissão do Paciente , Complicações Pós-Operatórias/mortalidade , Complicações Pós-Operatórias/terapia , Desenho de Prótese , Valva Pulmonar/diagnóstico por imagem , Valva Pulmonar/fisiopatologia , Insuficiência da Valva Pulmonar/economia , Insuficiência da Valva Pulmonar/mortalidade , Insuficiência da Valva Pulmonar/fisiopatologia , Recuperação de Função Fisiológica , Estudos Retrospectivos , Fatores de Risco , Fatores de Tempo , Resultado do Tratamento , Estados Unidos , Obstrução do Fluxo Ventricular Externo/economia , Obstrução do Fluxo Ventricular Externo/mortalidade , Obstrução do Fluxo Ventricular Externo/fisiopatologia , Adulto Jovem
5.
Acta Cardiol ; 72(4): 419-424, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28705054

RESUMO

Objective The aim of the study was to assess the feasibility of using commonly available catheterization laboratory equipment for radiofrequency perforation of the pulmonary valve in patients with pulmonary atresia and intact ventricular septum. Methods The system (off-label use for all items) is made up of a co-axial telescopic arrangement consisting of a 0.014" PT 2 ™ coronary guidewire, for insulation inside a 2.7-F microcatheter which has an inner lumen of 0.021". The microcatheter was passed via a standard 4-F right coronary catheter to just below the atretic pulmonary valve. Radiofrequency (RF) energy was delivered using a standard electrosurgical system. In vitro testing had been performed and indicated that 5-10 W for 2-5 s would be sufficient for valve perforation. Results Radiofrequency perforation was successfully performed in all (n = 5, 100%) patients at a median age of 3 days (range: 1-36) and weight 2.7 kg (range 2.3-3.0). In one patient the pericardium was entered during the initial attempt; the generator was put on coagulation mode during retrieval of the guidewire and no haemopericardium occurred. The pulmonary valve was dilated in all; in three patients (n = 3) the ductus arteriosus was stented during the same session. Conclusion Results of the study show that it is feasible to perforate the pulmonary valve safely using this system. Availability, simplicity and cost are noteworthy benefits.


Assuntos
Angioplastia com Balão , Ablação por Cateter , Cardiopatias Congênitas/cirurgia , Atresia Pulmonar/cirurgia , Valva Pulmonar/cirurgia , Angioplastia com Balão/efeitos adversos , Angioplastia com Balão/economia , Angioplastia com Balão/instrumentação , Cateteres Cardíacos , Ablação por Cateter/efeitos adversos , Ablação por Cateter/economia , Ablação por Cateter/instrumentação , Angiografia Coronária , Análise Custo-Benefício , Estudos de Viabilidade , Feminino , Custos de Cuidados de Saúde , Cardiopatias Congênitas/diagnóstico por imagem , Cardiopatias Congênitas/economia , Cardiopatias Congênitas/fisiopatologia , Humanos , Lactente , Recém-Nascido , Masculino , Atresia Pulmonar/diagnóstico por imagem , Atresia Pulmonar/economia , Atresia Pulmonar/fisiopatologia , Valva Pulmonar/diagnóstico por imagem , Valva Pulmonar/fisiopatologia , Stents , Resultado do Tratamento
6.
Asian Cardiovasc Thorac Ann ; 24(1): 5-11, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26567554

RESUMO

BACKGROUND: Chronic pulmonary regurgitation is common after repair of tetralogy of Fallot. Despite the deleterious effects of chronic pulmonary regurgitation on right ventricular function, many patients with repaired tetralogy of Fallot remain asymptomatic. Health is defined not only by the absence of disease but also by physical, mental, and social wellbeing. We sought to examine the impact of pulmonary valve replacement on quality of life in asymptomatic patients with repaired tetralogy of Fallot and chronic pulmonary regurgitation. METHODS: From January 2009 to December 2012, 25 (18 male) asymptomatic patients (mean age 23.4 ± 7.4 years) who underwent pulmonary valve replacement for significant pulmonary regurgitation were recruited. Cardiac magnetic resonance was performed pre- and postoperatively. Quality of life was assessed using the Chinese version of the SF-36v2 evaluation tool. Demographics, clinical data, magnetic resonance findings, and quality-of-life scores were collected and calculated for comparison. RESULTS: After surgery, the indexed right ventricular end-diastolic volume (193 ± 47.3 vs. 105.6 ± 29.6 mL m(-2), p < 0.001) and indexed right ventricular end-systolic volume (108.5 ± 32.9 vs. 61.1 ± 23 mL m(-2), p < 0.001) decreased significantly. The response rates for pre- and postoperative quality-of-life assessments were 100%. Patients demonstrated improvements in all 8 domains of the SF-36v2 assessment. The physical (46.5 ± 6.6 vs. 49.9 ± 6.4, p = 0.012) and mental (43.7 ± 7.8 vs. 51.9 ± 7.6, p < 0.001) component summary scores increased after surgery. CONCLUSION: Pulmonary valve replacement can improve the quality of life in patients with chronic asymptomatic pulmonary regurgitation.


Assuntos
Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Implante de Prótese de Valva Cardíaca , Insuficiência da Valva Pulmonar/cirurgia , Valva Pulmonar/cirurgia , Qualidade de Vida , Tetralogia de Fallot/cirurgia , Adolescente , Adulto , Doenças Assintomáticas , Doença Crônica , Feminino , Humanos , Imagem Cinética por Ressonância Magnética , Masculino , Saúde Mental , Valva Pulmonar/fisiopatologia , Insuficiência da Valva Pulmonar/diagnóstico , Insuficiência da Valva Pulmonar/etiologia , Insuficiência da Valva Pulmonar/fisiopatologia , Insuficiência da Valva Pulmonar/psicologia , Recuperação de Função Fisiológica , Volume Sistólico , Inquéritos e Questionários , Tetralogia de Fallot/diagnóstico , Tetralogia de Fallot/fisiopatologia , Fatores de Tempo , Resultado do Tratamento , Função Ventricular Direita , Adulto Jovem
7.
Expert Rev Med Devices ; 12(6): 653-65, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26513599

RESUMO

Synthetic conduits and bioprosthetic valves are used in the treatment of patients with congenital heart disease involving the right ventricular outflow tract and pulmonary valve. In-situ time-dependent degradation uniformly results in conduit and valve dysfunction. The abnormal hemodynamics imposed by valve and conduit dysfunction have been linked to exercise intolerance, arrhythmia, right heart failure, and sudden death. Starting in childhood, affected patients are subjected to repeated open-heart surgeries to restore valve function and potentially reduce morbidity and mortality. Percutaneous transcatheter pulmonary valve replacement with the Melody Transcatheter Pulmonary Valve (Medtronic, Inc., Minneapolis, MN) has been performed in ≈8000 patients worldwide. The valve and implant procedure provide a far less invasive means of restoring valve and conduit function and allow patients to forego multiple operations. Recent clinical trials have shown excellent and durable results in terms of valve function, relief of obstruction, and improvement in functional class up to 7 years from implant.


Assuntos
Cateterismo Cardíaco , Implante de Prótese de Valva Cardíaca , Artéria Pulmonar/fisiopatologia , Valva Pulmonar/fisiopatologia , Disfunção Ventricular Direita/cirurgia , Ensaios Clínicos como Assunto , Implante de Prótese de Valva Cardíaca/economia , Implante de Prótese de Valva Cardíaca/legislação & jurisprudência , Humanos , Complicações Pós-Operatórias/etiologia
8.
Arch Cardiovasc Dis ; 108(1): 5-15, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25453716

RESUMO

BACKGROUND: Evaluation of the right ventricle (RV) using transthoracic echocardiography is challenging in patients with repaired tetralogy of Fallot (rTOF). AIMS: To evaluate the accuracy of conventional echocardiographic variables and real-time three-dimensional echocardiography (RT3DE) in assessing right ventricular (RV) volumes and function compared with magnetic resonance imaging (MRI), in adult patients with rTOF and referred for pulmonary valve replacement (PVR). METHODS: Complete echocardiography was performed on 26 consecutive patients referred for PVR, before and 1 year after surgery. All variables were compared with MRI. RESULTS: Correlations between conventional variables and MRI were absent or poor when assessing RV ejection fraction (RVEF), except for fractional area of change (FAC; r=0.70, P<0.01 before PVR; r=0.68, P<0.01 after PVR) and RT3DE (r=0.96, P<0.01 before PVR; r=0.98, P<0.01 after PVR). The RV volume correlation between RT3DE and MRI was excellent before and after surgery for RV end-diastolic volume (r=0.88, P<0.01 and r=0.91, P<0.01, respectively) and RV end-systolic volume (r=0.92, P<0.01 and r=0.95, P<0.01, respectively). The accuracy of these indices, as a diagnostic test for impaired RV (<45%), was good: Youden's indexes varied from 0.47 to 0.89; areas under the receiver operating characteristic curve before and after PVR were 0.86 and 0.81 for FAC and 0.98 and 0.97 for RT3DE, respectively. CONCLUSION: Commonly used echocardiography variables, such as tricuspid annular plane systolic excursion and tricuspid annular peak systolic velocity, did not sensitively evaluate global RVEF. A global approach, that includes the whole RV and integration of its different components, was more reliable in patients with rTOF.


Assuntos
Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Ecocardiografia Tridimensional , Implante de Prótese de Valva Cardíaca , Ventrículos do Coração/diagnóstico por imagem , Imageamento por Ressonância Magnética , Insuficiência da Valva Pulmonar/cirurgia , Valva Pulmonar/cirurgia , Tetralogia de Fallot/cirurgia , Disfunção Ventricular Direita/diagnóstico por imagem , Função Ventricular Direita , Adolescente , Adulto , Área Sob a Curva , Estudos de Viabilidade , Feminino , Ventrículos do Coração/fisiopatologia , Humanos , Masculino , Análise Multivariada , Valor Preditivo dos Testes , Valva Pulmonar/diagnóstico por imagem , Valva Pulmonar/fisiopatologia , Insuficiência da Valva Pulmonar/diagnóstico por imagem , Insuficiência da Valva Pulmonar/etiologia , Insuficiência da Valva Pulmonar/fisiopatologia , Curva ROC , Volume Sistólico , Fatores de Tempo , Resultado do Tratamento , Valva Tricúspide/diagnóstico por imagem , Valva Tricúspide/fisiopatologia , Disfunção Ventricular Direita/etiologia , Disfunção Ventricular Direita/fisiopatologia , Adulto Jovem
9.
Arch Cardiovasc Dis ; 107(11): 615-24, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25445753

RESUMO

The epidemiology of infective endocarditis is changing rapidly due to the emergence of resistant microorganisms, the indiscriminate use of antibiotics, and an increase in the implantation of cardiovascular devices including percutaneous valves. Percutaneous pulmonary valve implantation has achieved standard of care for the management of certain patients with right ventricular outflow tract dysfunction. With its expanding use, several cases of early and delayed infective endocarditis with higher morbidity and mortality rates have been reported. This review summarizes the trends in percutaneous pulmonary valve infective endocarditis, postulates proposed mechanisms, and elaborates on the prevention and management of this unique and potentially fatal complication.


Assuntos
Cateterismo Cardíaco/efeitos adversos , Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Endocardite , Cardiopatias Congênitas/cirurgia , Doenças das Valvas Cardíacas/terapia , Implante de Prótese de Valva Cardíaca/efeitos adversos , Próteses Valvulares Cardíacas/efeitos adversos , Infecções Relacionadas à Prótese , Valva Pulmonar , Cateterismo Cardíaco/instrumentação , Cateterismo Cardíaco/métodos , Endocardite/diagnóstico , Endocardite/epidemiologia , Endocardite/prevenção & controle , Endocardite/terapia , Doenças das Valvas Cardíacas/diagnóstico , Doenças das Valvas Cardíacas/etiologia , Doenças das Valvas Cardíacas/fisiopatologia , Implante de Prótese de Valva Cardíaca/instrumentação , Implante de Prótese de Valva Cardíaca/métodos , Humanos , Incidência , Desenho de Prótese , Infecções Relacionadas à Prótese/diagnóstico , Infecções Relacionadas à Prótese/epidemiologia , Infecções Relacionadas à Prótese/prevenção & controle , Infecções Relacionadas à Prótese/terapia , Valva Pulmonar/fisiopatologia , Medição de Risco , Fatores de Risco , Resultado do Tratamento
10.
Heart ; 100(17): 1354-9, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24780907

RESUMO

OBJECTIVE: In adult patients with mild-to-moderate pulmonary valve (PV) stenosis, exercise capacity and haemodynamics have not been extensively studied, although regular exercise is recommended. Therefore, we aimed to assess exercise capacity to study the increase in PV gradient during exercise and to evaluate the impact of this increased pressure load on the RV. METHODS: Nineteen patients (8 female; 29±6.4 years) with isolated mild-to-moderate PV stenosis and no prior cardiac interventions were consecutively enrolled from the outpatient clinic of adult congenital heart disease. All patients underwent cardiopulmonary exercise testing, transthoracic echocardiography and bicycle stress echocardiography. Results for exercise testing were compared with age-matched and gender-matched control patients. RESULTS: In the studied population, resting heart rate (89±11 vs 75±14 bpm; p=0.001), peak power (199±66 vs 263±68 W; p=0.006); peak VO2 (31.2±9.9 vs 39±7.4 mL/kg/min; p=0.011); oxygen uptake efficiency slope (2430±913 vs 3292±943(mL/min)/(L/min); p=0.007) and VE/VCO2 slope (26.8±5.2 vs 22.6±4.3; p=0.01) differed significantly from controls. A linear increase of peak PV gradient with increasing flow was observed in the pooled dataset (Pearson's R=0.947; p<0.0001) and slopes identical as for control patients were obtained for the oxygen pulse-workload relationship. Right heart morphology and function were preserved in the studied patients. CONCLUSIONS: Patients with mild-to-moderate PV stenosis have decreased exercise capacity. A linear increase in PV gradient with flow suggests a fixed valve area throughout the exercise. Although systolic RV pressure load increases during exercise, good ventricular performance was observed without signs of functional or morphological changes of the right heart. CLINICAL TRIAL NUMBER: NCT01444222.


Assuntos
Teste de Esforço , Tolerância ao Exercício , Hemodinâmica , Estenose da Valva Pulmonar/diagnóstico , Valva Pulmonar/fisiopatologia , Adulto , Distribuição de Qui-Quadrado , Ecocardiografia Doppler em Cores , Ecocardiografia Doppler de Pulso , Feminino , Frequência Cardíaca , Humanos , Modelos Lineares , Masculino , Consumo de Oxigênio , Valor Preditivo dos Testes , Valva Pulmonar/diagnóstico por imagem , Estenose da Valva Pulmonar/fisiopatologia , Índice de Gravidade de Doença , Função Ventricular Direita , Pressão Ventricular , Adulto Jovem
11.
Congenit Heart Dis ; 3(6): 415-21, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-19037982

RESUMO

OBJECTIVE: Few reports have been published on the Doppler-derived echocardiographic data for pulmonary valve prostheses (PVPs). The aim of this study was to provide a comprehensive Doppler echocardiographic assessment of PVPs. METHODS: We studied 40 patients (mean age 24.2) with PVPs: 13 (32.5%) mechanical and 27 (67.5%) bioprosthetic valves. After clinical evaluation, all patients underwent complete, two-dimensional and Doppler studies. RESULTS: In 30 patients with normally functioning PVPs, the mean (SD) peak velocity was 2.33 (0.36) m/s with an average peak pressure gradient of 22.69 (6.7) mm Hg and an average mean pressure gradient of 12.5 (4.1) mm Hg. The mean PVPs velocity time integral (VTI) was 47.49 (12.78) cm with mean right ventricle outflow tract/peak velocity (PV) VTI ratio 0.43 (0.14), mean PVPs effective orifice area was 1.63 (0.36) cm(2). Metallic PVPs had significantly better hemodynamic Doppler study compared with biologic PVPs. In 9 patients with PVP malfunction, average peak PVPs velocity, average peak pressure gradient, mean pressure gradient, PV VTI, PV/left ventricle outflow tract VTI ratio was significantly increased (P < 0.05). CONCLUSION: This study contributes to establishing the normal range for Doppler hemodynamics in various PVPs.


Assuntos
Bioprótese , Ecocardiografia Doppler , Doenças das Valvas Cardíacas/diagnóstico por imagem , Implante de Prótese de Valva Cardíaca/instrumentação , Próteses Valvulares Cardíacas , Hemodinâmica , Valva Pulmonar/diagnóstico por imagem , Adolescente , Adulto , Bases de Dados como Assunto , Feminino , Doenças das Valvas Cardíacas/fisiopatologia , Doenças das Valvas Cardíacas/cirurgia , Humanos , Masculino , Metais , Pessoa de Meia-Idade , Desenho de Prótese , Falha de Prótese , Valva Pulmonar/fisiopatologia , Valva Pulmonar/cirurgia , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
12.
Clin Chest Med ; 22(3): 493-508, ix, 2001 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11590843

RESUMO

The goals of evaluating pulmonary hypertension are detection, definition of severity and the nature of the hemodynamic lesion and its consequences, diagnosis of causal or associated conditions, and determination of optimal therapy. These objectives are reliably achieved by a disciplined approach employing multiple diagnostic tools. This chapter outlines the fundamental background and guidelines for assessing pulmonary hypertension, including consideration of several new and less frequently used methods to elucidate the physiologic mechanism. Since early detection and treatment may improve outcome, screening higher risk populations and a diagnostic approach to the milder spectrum of pulmonary hypertension is also addressed.


Assuntos
Hipertensão Pulmonar/diagnóstico , Algoritmos , Cateterismo Cardíaco , Diagnóstico Diferencial , Ecocardiografia Doppler , Ecocardiografia Transesofagiana , Humanos , Hipertensão Pulmonar/diagnóstico por imagem , Hipertensão Pulmonar/fisiopatologia , Imageamento por Ressonância Magnética , Prognóstico , Artéria Pulmonar/fisiopatologia , Valva Pulmonar/fisiopatologia , Testes de Função Respiratória , Resistência Vascular , Relação Ventilação-Perfusão , Função Ventricular Direita
13.
Artigo em Alemão | MEDLINE | ID: mdl-9531669

RESUMO

Pulmonary venous flow velocity pattern, transmitral flow pattern, isovolumic relaxation time, and left ventricular fractional wall thinning were analyzed in 72 dogs with heart disease by transthoracic Doppler and M-mode echocardiography and compared with other noninvasive variables of left ventricular and left atrial systolic performance. Abnormal diastolic blood flow was found in 49 (68%) dogs, predominantly flow patterns suggestive of relaxation abnormality and increased filling pressures. Diastolic flow abnormalities despite normal systolic performance were found in 23 (32%) dogs of which 14 (61%) revealed clinical signs of heart disease. The diagnostic sensitivity of pulmonary venous flow parameters for echocardiographically detectable diastolic disturbance was found to be higher compared with the other noninvasive parameters of diastolic heart function measured. Diastolic filling pattern appear to correlate closer with functional status in many dogs with heart disease than indices of systolic performance.


Assuntos
Diástole , Ecocardiografia Doppler/veterinária , Cardiopatias/veterinária , Função Ventricular Esquerda , Animais , Cães , Ecocardiografia Doppler/métodos , Cardiopatias/diagnóstico por imagem , Cardiopatias/fisiopatologia , Frequência Cardíaca , Estudos Prospectivos , Valva Pulmonar/diagnóstico por imagem , Valva Pulmonar/fisiologia , Valva Pulmonar/fisiopatologia , Valores de Referência , Sístole , Disfunção Ventricular Esquerda/diagnóstico por imagem , Disfunção Ventricular Esquerda/fisiopatologia , Disfunção Ventricular Esquerda/veterinária
14.
Am J Cardiol ; 68(6): 648-52, 1991 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-1831588

RESUMO

Patients with severe pulmonic stenosis (PS) have right ventricular (RV) diastolic filling abnormalities detectable by tricuspid valve pulsed Doppler examination. To determine if these abnormalities persist long term after successful therapy of PS, 19 patients were examined 8 +/- 3 years after PS therapy. At the time of follow-up Doppler examination, the PS gradient was 15 +/- 8 mm Hg. From the tricuspid valve inflow Doppler study, the following measurements were obtained at peak inspiration: peak velocities at rapid filling (peak E) and during atrial contraction (peak A), ratio of peak E to peak A velocities, RV peak filling rate normalized for stroke volume, deceleration time, the fraction of filling in the first 0.33 of diastole as well as under the E and A waves, and the ratio of E to A area. Data from PS follow-up patients were compared with our previously reported data from 12 age-related control subjects and 14 untreated patients with PS. Patients with PS who were followed up had higher peak E velocity (0.75 +/- 0.14 vs 0.59 +/- 0.21 m/s), lower peak A velocity (0.47 +/- 0.09 vs 0.64 +/- 0.28 m/s), higher E/A velocity ratio (1.65 +/- 0.33 vs 1.11 +/- 0.52), higher 0.33 area fraction (0.52 +/- 0.08 vs 0.34 +/- 0.14), lower A area fraction (0.29 +/- 0.06 vs 0.45 +/- 0.21) and higher E/A area ratio (2.48 +/- 0.82 vs 1.73 +/- 1.05) than PS patients without treatment (p less than 0.03). All Doppler indexes of the patients with PS who were followed up were the same as those of the control subjects except for the peak E velocity that was slightly higher (0.75 +/- 0.14 vs 0.63 +/- 0.11 m/s), the peak A velocity that was slightly higher (0.47 +/- 0.09 vs 0.38 +/- 0.09 m/s) and the E/A area ratio that was slightly lower (2.48 +/- 0.82 vs 3.50 +/- 1.25) (p less than 0.03). Thus, at long-term follow-up, all RV diastolic filling indexes in successfully treated patients with PS improved compared with the untreated patients and approached values found in normal subjects.(ABSTRACT TRUNCATED AT 250 WORDS)


Assuntos
Volume Cardíaco/fisiologia , Diástole/fisiologia , Estenose da Valva Pulmonar/cirurgia , Função Ventricular Direita/fisiologia , Adolescente , Adulto , Velocidade do Fluxo Sanguíneo/fisiologia , Cardiomegalia/fisiopatologia , Cateterismo , Criança , Pré-Escolar , Ecocardiografia Doppler , Seguimentos , Humanos , Valva Pulmonar/fisiopatologia , Insuficiência da Valva Pulmonar/diagnóstico por imagem , Insuficiência da Valva Pulmonar/fisiopatologia , Estenose da Valva Pulmonar/diagnóstico por imagem , Estenose da Valva Pulmonar/fisiopatologia , Estenose da Valva Pulmonar/terapia , Volume Sistólico/fisiologia , Fatores de Tempo
15.
Am J Cardiol ; 61(8): 595-601, 1988 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-3344684

RESUMO

The influence of pulmonary regurgitation (PR) on exercise capacity is unknown. The hemodynamic responses to exercise in postoperative patients with PR was determined using Doppler-measured regurgitant fraction to indicate PR severity. Maximal heart rate, oxygen consumption and workload capacity were measured during upright cycle ergometry. Cardiac output was measured at rest and during submaximal supine cycle ergometry by pulsed Doppler echocardiography. Oxygen consumption was simultaneously measured and exercise factor was calculated as the change in cardiac output per change in oxygen consumption. Twenty-seven patients were compared with 17 age-, size- and sex-matched control subjects. Patients with PR had larger right ventricles (p less than or equal to 0.001), lower heart rate response (p less than or equal to 0.05), lower maximal oxygen consumption (p less than or equal to 0.005) and lower workloads (p less than or equal to 0.005) when compared with normal control subjects during maximal exercise testing. Exercise factor was the same for both groups. Patients with PR were then separated into mild, moderate and severe groups. Patients with mild PR had a normal response to exercise. However, patients with moderate and severe PR had lower maximal oxygen consumptions and maximal workloads than control subjects. Control, mild and moderate PR groups had similar exercise factors. Patients with severe PR had markedly low cardiac output responses. PR is associated with reduced exercise capability, which is related to the severity of the PR.


Assuntos
Hemodinâmica , Esforço Físico , Insuficiência da Valva Pulmonar/fisiopatologia , Valva Pulmonar/cirurgia , Adolescente , Aorta/fisiopatologia , Velocidade do Fluxo Sanguíneo , Débito Cardíaco , Criança , Ecocardiografia , Coração/fisiopatologia , Cardiopatias Congênitas/cirurgia , Frequência Cardíaca , Humanos , Consumo de Oxigênio , Resistência Física , Complicações Pós-Operatórias , Valva Pulmonar/fisiopatologia , Insuficiência da Valva Pulmonar/etiologia , Estenose da Valva Pulmonar/cirurgia
16.
Br Heart J ; 53(6): 640-4, 1985 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-4005087

RESUMO

During a previous investigation and during routine clinical Doppler echocardiography velocities distal to normal valves were found to be increased in patients with congenital heart disease. To investigate this observation the velocity proximal and distal to cardiac valves was recorded in 56 patients with congenital heart disease. No detectable pressure gradient had been found across these valves at catheterisation and no velocity gradient greater than 20 cm/s was found across them by range gated Doppler echocardiography. In 82% of the patients, however, the blood velocity across one or more valves exceeded normal limits. Increased velocities were found at the tricuspid inflow (55%), pulmonary artery (38%), mitral inflow (34%), and ascending aorta (11%). Factors predisposing to the presence of increased velocities in these areas were increased flow through the valve and decreased compliance of the receiving chamber. This study shows the necessity for recording velocity both proximal and distal to a valve before a gradient is calculated according to the modified Bernouilli equation.


Assuntos
Cardiopatias Congênitas/fisiopatologia , Adolescente , Adulto , Estenose da Valva Aórtica/fisiopatologia , Velocidade do Fluxo Sanguíneo , Criança , Pré-Escolar , Ecocardiografia , Humanos , Lactente , Valva Mitral/fisiopatologia , Valva Pulmonar/fisiopatologia , Valva Tricúspide/fisiopatologia
17.
Pediatr Cardiol ; 4(3): 209-14, 1983.
Artigo em Inglês | MEDLINE | ID: mdl-6647104

RESUMO

Echocardiographic patterns of pulmonary valve motion and right-sided systolic time intervals were correlated with pulmonary arterial hemodynamics in 56 children with congenital heart defects. The sensitivity of an abnormal a-dip, reduced e-f slope or mid-systolic valve closure in detecting elevated pulmonary artery diastolic or mean pressures or pulmonary to systemic resistance ratio varied from 36 to 62%. Specificities ranged from 50% (e-f slope for increased Rp:Rs) to 93% (mid-systolic closure for PA diastolic pressure greater than 10 mm Hg). Systolic-time-intervals (RPEP/RVET) did not significantly correlate with pulmonary hemodynamics. We therefore conclude that these echocardiographic features are insufficiently sensitive to be clinically applied to detect pulmonary hypertension in pediatric patients, and that only 2 (a-dip and mid-systolic closure) were of sufficient specificity to be useful.


Assuntos
Ecocardiografia , Hipertensão Pulmonar/diagnóstico , Valva Pulmonar/fisiopatologia , Adolescente , Adulto , Criança , Pré-Escolar , Frequência Cardíaca , Humanos , Hipertensão Pulmonar/fisiopatologia , Lactente , Recém-Nascido , Sístole
18.
Am J Cardiol ; 47(4): 950-62, 1981 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-7010979

RESUMO

Noninvasive radiographic techniques have provided a means of studying the natural history and pathogenesis of cardiovascular performance in acute and chronic respiratory failure. Chest radiography, radionuclide angiocardiography and thallium-201 imaging, and M mode and cross-sectional echocardiography have been employed. Each of these techniques has specific uses, attributes and limitations. For example, measurement of descending pulmonary arterial diameters on the plain chest radiograph allows determination of the presence or absence of pulmonary arterial hypertension. Right and left ventricular performance can be evaluated at rest and during exercise using radionuclide angiocardiography. The biventricular response to exercise and to therapeutic interventions also can be assessed with this approach. Evaluation of the pulmonary valve echogram and echocardiographic right ventricular dimensions have been shown to reflect right ventricular hemodynamics and size. Each of these noninvasive techniques has been applied to the study of patients with respiratory failure and has provided important physiologic data.


Assuntos
Sistema Cardiovascular/diagnóstico por imagem , Insuficiência Respiratória/diagnóstico por imagem , Doença Aguda , Aminofilina/uso terapêutico , Pressão Sanguínea , Sistema Cardiovascular/fisiopatologia , Doença Crônica , Fibrose Cística/diagnóstico por imagem , Ecocardiografia , Teste de Esforço , Ventrículos do Coração/diagnóstico por imagem , Ventrículos do Coração/fisiopatologia , Pneumopatias Obstrutivas/diagnóstico por imagem , Valva Pulmonar/fisiopatologia , Radiografia Torácica , Radioisótopos , Cintilografia , Insuficiência Respiratória/tratamento farmacológico , Tálio , Teofilina/uso terapêutico
19.
Br Heart J ; 42(2): 147-61, 1979 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-486275

RESUMO

To assess the validity of ultrasound criteria for pulmonary arterial hypertension, we studied pulmonary valve motion in 28 patients and 20 normal subjects. In the latter group, we categorised normal movement of the posterior leaflet of the pulmonary valve in a fashion not previously described. Of the 28 patients, 19 had pulmonary arterial hypertension (pulmonary artery mean pressure more than 20 mmHg, range 22 to 72). Negative, flat, and positive e to f slopes occurred equally in normal subjects and patients. Maximal a wave excursion was less than 2 mm in 9 of 13 patients with pulmonary hypertension who had sinus rhythm, but was more than 2 mm in all normals and in the 9 patients with normal pulmonary artery pressure (69% sensitivity and 100% specificity). The b to c slope was more than 450 mm/s in 6 of 18 patients with pulmonary arterial hypertension and was less than 450 mm/s in all others (33% sensitivity and 100% specificity). The normalised right ventricular pre-ejection period was more than 0.095 (range 0.10 to 0.16) in 13 of the 19 patients with pulmonary arterial hypertension and less than 0.095 in all others (68% sensitivity and 100% specificity). A midsystolic notch occurred in patients with pulmonary arterial hypertension and in no normal subjects or patients with normal pulmonary arterial pressure. Of the 19 patients with pulmonary arterial hypertension, 18 were identified by one or more ultrasound criteria. Of the 5 patients who met only 1 criterion (increased normalised right ventricular pre-ejection period), 4 had atrial fibrillation. We conclude that measurement of the pulmonary valve e to f slope is useless for identifying pulmonary arterial hypertension. However, changes in normalised right ventricular pre-ejection, maximal a wave excursion, b to c slope, and the presence of a midsystolic notch, while insensitive, are highly specific for pulmonary atrial hypertension.


Assuntos
Ecocardiografia , Hipertensão Pulmonar/diagnóstico , Valva Pulmonar/fisiopatologia , Adolescente , Adulto , Idoso , Arritmia Sinusal/fisiopatologia , Fibrilação Atrial/fisiopatologia , Cateterismo Cardíaco , Eletrocardiografia , Feminino , Ventrículos do Coração/fisiopatologia , Humanos , Hipertensão Pulmonar/fisiopatologia , Masculino , Pessoa de Meia-Idade , Valva Pulmonar/fisiologia , Sístole
20.
Schweiz Med Wochenschr ; 109(29): 1067-76, 1979 Jul 28.
Artigo em Francês | MEDLINE | ID: mdl-472691

RESUMO

Mode-M echocardiography is the most valuable non invasive technique in cardiology, but as a one-dimensional technique it displays the cardiac structure in an unfamiliar form without resemblance to the cardiac anatomy. Two-dimensional ultrasonic imaging of the heart overcomes this disadvantage. However, the definition of these scanners leaves much to be desired and becomes very poor when the stop-frame mode is used. The major disadvantages of the "multiscan" are the length of the multicrystal transducer, distortion of the picture, spurious echoes and verticalization. The sector scanner has smaller transducers fitting the "echocardiographic window" and permitting an apical, subxiphoid and suprasternal approach. However, with this system resolution is usually poor in the first anterior 3.5--4 cm after the thoracic wall. The mechanical scanner causes a vibrating sensation occasionally irritating to the patient. The electronic sector scanner has the widest angle and provides the best quality images. Unfortunately, its cost is markedly higher than that of other two-dimensional systems.


Assuntos
Ecocardiografia/instrumentação , Valva Aórtica/fisiopatologia , Criança , Pré-Escolar , Ecocardiografia/economia , Feminino , Humanos , Pessoa de Meia-Idade , Valva Mitral/fisiopatologia , Estenose da Valva Mitral/diagnóstico , Valva Pulmonar/fisiopatologia , Vibração
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