Asociación entre el polimorfismo rs9939609 del gen FTO con la ingesta energética, macronutrientes y consumo de alcohol en población chilena / Association of the FTO (rs9939609) genotype with energy intake
Rev. méd. Chile
; 146(11): 1252-1260, nov. 2018. tab, graf
Article
em Es
| LILACS
| ID: biblio-985698
Biblioteca responsável:
CL1.1
RESUMEN
Background:
Fat-mass-associated-gene (FTO) is associated with higher energy intake and specific food preferences.Aim:
To investigate the association of the FTO genotype with energy intake, macronutrient and alcohol consumption. Material andMethods:
Four hundred and nine participants of the GENADIO (Genes, Environment, Diabetes and Obesity) study were included. Energy intake, macronutrient and alcohol consumption were the outcomes of interest. The association of FTO (rs9939609) genotype with these outcomes was investigated using linear regression analyses, adjusting for confounding variables.Results:
After adjusting for socio-demographic factors, being a carrier of the risk allele for the FTO gene was associated with a higher energy intake (173 kcal per each extra copy of the risk variant [95% confidence intervals (CI) 45; 301], (P = 0.008). After adjusting for lifestyle factors and body mass index, the association was slightly attenuated but remained significant (144 kcal [95% CI 14; 274], p = 0.030).Conclusions:
The FTO genotype is associated with a higher energy intake.Palavras-chave
Texto completo:
1
Temas:
ECOS
/
Equidade_desigualdade
Bases de dados:
LILACS
Assunto principal:
Ingestão de Energia
/
Consumo de Bebidas Alcoólicas
/
Nutrientes
/
Dioxigenase FTO Dependente de alfa-Cetoglutarato
/
Genótipo
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspecto:
Equity_inequality
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Chile
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Chile
/
Reino Unido