Working memory control in patients with schizophrenia: a PET study during a random number generation task.
Am J Psychiatry
; 157(9): 1517-9, 2000 Sep.
Article
em En
| MEDLINE
| ID: mdl-10964875
ABSTRACT
OBJECTIVE:
The authors' goal was to investigate brain regions involved in the deficiency of working memory control processes in patients with schizophrenia.METHOD:
Regional cerebral blood flow was measured with positron emission tomography in eight men with stabilized schizophrenia and eight healthy men while they were performing a graded random number generation task. Twelve scans were made for each subject. Covariations between randomness of responses and regional activation were analyzed.RESULTS:
The pattern of covariation between randomness of responses and activation in the anterior cingulate and superior parietal regions differed between patients and healthy subjects.CONCLUSIONS:
These results suggest a cinguloparietal dysfunction underlying the impairment of working memory control processes during a random number generation task in patients with schizophrenia.
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Temas:
ECOS
/
Financiamentos_gastos
Bases de dados:
MEDLINE
Assunto principal:
Lobo Parietal
/
Esquizofrenia
/
Psicologia do Esquizofrênico
/
Tomografia Computadorizada de Emissão
/
Giro do Cíngulo
/
Memória
Tipo de estudo:
Clinical_trials
/
Health_economic_evaluation
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Psychiatry
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
França