[Analysis of cost minimization of monotherapy antiepileptic treatment in patients with recent diagnosed epilepsy : the situation in Spain]. / Análisis de coste-minimización del tratamiento antiepiléptico en monoterapia en pacientes con epilepsia de reciente diagnóstico: situación en España.
Rev Neurol
; 31(9): 828-32, 2000.
Article
em Es
| MEDLINE
| ID: mdl-11127083
ABSTRACT
OBJECTIVE:
To analyze the cost of monotherapeutic treatment of patients with newly diagnosed epilepsy. PATIENTS ANDMETHODS:
We analysed the cost of treatment with lamotrigine (LTG), carbamazepine (CBZ), phenytoin (PHT) and valproic acid (VPA) using published data regarding the efficacy and tolerability of comparative clinical trials of monotherapy. We established a model of treatment for newly diagnosed patients during the first 12 months after diagnosis. A panel of doctors reached a consensus on the use of resources, costs and model of treatment in Spain. We made a cost minimization analysis for economic assessment of the data based on the fact that randomized trials indicated that CBZ, LTG, PHT and VPA ware of similar efficacy. Analysis was done as 'intention to treat'. Only direct medical costs were considered.RESULTS:
In Spain treatment with LTG is twice or three times as expensive as treatment with the other drugs. Sensitivity analysis showed that variations in the interval of use of resources and of costs (defined by the panel of doctors) did not significantly alter the results.CONCLUSIONS:
Treatment with LTG is more expensive than treatment with the classical drugs. In view of the methodological limitations of this study, further analysis is necessary, particularly of the methodology of cost-benefit, to evaluate the economic impact of the new antiepileptic drugs and determine whether their use is justified as drugs of first choice.
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Temas:
ECOS
/
Aspectos_gerais
/
Avaliacao_economica
/
Financiamentos_gastos
Bases de dados:
MEDLINE
Assunto principal:
Epilepsia
/
Anticonvulsivantes
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Health_economic_evaluation
Limite:
Child
/
Humans
País/Região como assunto:
Europa
Idioma:
Es
Revista:
Rev Neurol
Ano de publicação:
2000
Tipo de documento:
Article