Noninvasive assessment of cerebral oxygenation during acclimation to hypobaric hypoxia.
J Cereb Blood Flow Metab
; 20(12): 1632-5, 2000 Dec.
Article
em En
| MEDLINE
| ID: mdl-11129779
ABSTRACT
Factors regulating cerebral tissue PO2 (PtO2) are complex. With the increased use of clinical PtO2 monitors, it has become important to elucidate these mechanisms. The authors are investigating a new methodology (electron paramagnetic resonance oximetry) for use in monitoring cerebral PtO2 in awake animals over time courses of weeks. The authors used this to study cerebral PtO2 in rats during chronic acclimation to hypoxia predicting that such acclimation would cause an increase in PtO2 because of increases that occur in capillary density and oxygen carrying capacity. The average PtO2 between 7 and 21 days was increased by 228% over controls.
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Temas:
ECOS
/
Aspectos_gerais
Bases de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Encéfalo
/
Aclimatação
/
Hipóxia
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Cereb Blood Flow Metab
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos