The peripheral nerve allograft in the primate immunosuppressed with Cyclosporin A: I. Histologic and electrophysiologic assessment.
Plast Reconstr Surg
; 90(6): 1036-46, 1992 Dec.
Article
em En
| MEDLINE
| ID: mdl-1448498
ABSTRACT
Nerve regeneration across peripheral nerve allografts and control autografts in primates immunosuppressed with Cyclosporin A was quantitatively evaluated by electrophysiologic and histologic methods. Twelve cynomolgus monkeys received 3-cm autografts and allografts in contralateral ulnar nerves. They were immunosuppressed with Cyclosporin A at 25 mg/kg per day or placebo vehicle. Morphometric analysis of nerve graft and distal nerve segments was assessed at 1 year after engraftment. Quantitative electrophysiologic studies were performed percutaneously at 6 and 12 months, and compound action potentials were measured directly across the nerve grafts at 1 year. Excellent regeneration was seen across autografts and allografts in Cyclosporin A-treated and placebo-treated recipients.
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Temas:
ECOS
/
Aspectos_gerais
Bases de dados:
MEDLINE
Assunto principal:
Nervo Sural
/
Hospedeiro Imunocomprometido
/
Ciclosporina
Tipo de estudo:
Observational_studies
Limite:
Animals
Idioma:
En
Revista:
Plast Reconstr Surg
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Canadá