Comparative analysis of alpha-blocker utilization in combination with 5-alpha reductase inhibitors for enlarged prostate in a managed care setting among Medicare-aged men.
Am J Manag Care
; 14(5 Suppl 2): S160-6, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18611090
ABSTRACT
OBJECTIVE:
To evaluate the likelihood of alpha-adrenergic antagonist (alpha-blocker) discontinuation in combination with dutasteride or finasteride among patients aged > or =65 years with enlarged prostate.METHOD:
This retrospective analysis used 2003-2006 data representing more than 30 million managed care members. Medical/pharmacy claims were used to select patients, matched 11 using propensity scoring. The proportion remaining on alpha-blocker therapy more than 12 months and time to discontinuation were compared between groups, controlling for covariates using survival analysis.RESULTS:
The matched sample included 1674 patients. Alpha-blocker therapy discontinuation was observed at 90 days (86.9% dutasteride patients and 91.8% finasteride patients remained on alpha-blocker therapy). After 12 months, more dutasteride patients discontinued (38.1% remained) alpha-blocker therapy than finasteride patients (56.3% remained).CONCLUSIONS:
Patients discontinued alpha-blocker therapy as early as 3 months. Those taking dutasteride were 64% more likely to discontinue alpha-blocker therapy than patients taking finasteride. Dutasteride's impact on discontinuation may have important implications and should be examined further.
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Temas:
ECOS
/
Aspectos_gerais
/
Estado_mercado_regulacao
Bases de dados:
MEDLINE
Assunto principal:
Hiperplasia Prostática
/
Azasteroides
/
Finasterida
/
Antagonistas Adrenérgicos alfa
/
Inibidores Enzimáticos
/
Inibidores de 5-alfa Redutase
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Humans
/
Male
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Am J Manag Care
Assunto da revista:
SERVICOS DE SAUDE
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos