An anthropomorphic breast model for breast imaging simulation and optimization.
Acad Radiol
; 18(5): 536-46, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21397528
ABSTRACT
RATIONALE AND OBJECTIVES:
Optimization studies for x-ray-based breast imaging systems using computer simulation can greatly benefit from a phantom capable of modeling varying anatomical variability across different patients. This study aimed to develop a three-dimensional phantom model with realistic and randomizable anatomical features. MATERIALS ANDMETHODS:
A voxelized breast model was developed consisting of an outer layer of skin and subcutaneous fat, a mixture of glandular and adipose, stochastically generated ductal trees, masses, and microcalcifications. Randomized realization of the breast morphology provided a range of patient models. Compression models were included to represent the breast under various compression levels along different orientations. A Monte Carlo (MC) simulation code was adapted to simulate x-ray based imaging systems for the breast phantom. Simulated projections of the phantom at different angles were generated and reconstructed with iterative methods, simulating mammography, breast tomosynthesis, and computed tomography (CT) systems. Phantom dose maps were further generated for dosimetric evaluation.RESULTS:
Region of interest comparisons of simulated and real mammograms showed strong similarities in terms of appearance and features. Noise-power spectra of simulated mammographic images demonstrated that the phantom provided target properties for anatomical backgrounds. Reconstructed tomosynthesis and CT images and dose maps provided corresponding data from a single breast enabling optimization studies. Dosimetry result provided insight into the dose distribution difference between modalities and compression levels.CONCLUSION:
The anthropomorphic breast phantom, combined with the MC simulation platform, generated a realistic model for a breast imaging system. The developed platform is expected to provide a versatile and powerful framework for optimizing volumetric breast imaging systems.
Texto completo:
1
Temas:
ECOS
/
Financiamentos_gastos
Bases de dados:
MEDLINE
Assunto principal:
Mamografia
/
Modelos Anatômicos
Tipo de estudo:
Clinical_trials
/
Health_economic_evaluation
Limite:
Humans
Idioma:
En
Revista:
Acad Radiol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos