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Aortic stiffness is related to left ventricular diastolic function in patients with diabetes mellitus type 1: assessment with MRI and speckle tracking strain analysis.
van Schinkel, Linda D; Auger, Dominique; van Elderen, Saskia G C; Ajmone Marsan, Nina; Delgado, Victoria; Lamb, Hildo J; Ng, Arnold C T; Smit, Johannes W A; Bax, Jeroen J; Westenberg, Jos J M; de Roos, Albert.
Afiliação
  • van Schinkel LD; Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, C4-67, 2333 ZA Leiden, The Netherlands. l.d.van_schinkel@lumc.nl
Int J Cardiovasc Imaging ; 29(3): 633-41, 2013 Mar.
Article em En | MEDLINE | ID: mdl-23001157
ABSTRACT
Diabetes mellitus type 1 (DM1) is associated with aortic stiffening and left ventricular (LV) diastolic dysfunction, however the relationship between aortic stiffness and LV diastolic dysfunction in DM1 patients is still largely unknown. The purpose of this study was to evaluate whether an increased aortic stiffness, expressed by increased aortic pulse wave velocity (PWV), is associated with subclinical LV diastolic dysfunction and decreased left atrial (LA) compliance as assessed with speckle tracking strain analysis in patients with DM1. Aortic PWV was assessed with cardiovascular magnetic resonance in 41 DM1 patients. Patients underwent echocardiography for assessment of conventional LV diastolic function indices and LV and LA longitudinal strain and strain rate (SR) assessed with speckle tracking strain analysis. LV SR during the isovolumic relaxation period (SRIVR) and LA strain were recorded and the E-wave velocity to SRIVR velocity ratio (E/SRIVR) was calculated. Independent samples t test and multivariate linear regression analyses were used for statistical analyses. Aortic PWV significantly correlated with SRIVR (ß = -0.71, p < 0.001), E/SRIVR (ß = 0.61, p = 0.002) and LA strain (ß = -0.47, p = 0.014), but not with conventional echocardiographic markers of diastolic function (all p > 0.10). In DM1 patients, aortic stiffness is inversely associated with sensitive markers of LV diastolic function and decrease in LA compliance as measured with echocardiographic speckle tracking strain analysis.
Assuntos

Texto completo: 1 Temas: ECOS / Aspectos_gerais Bases de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Ecocardiografia Doppler / Função Ventricular Esquerda / Disfunção Ventricular Esquerda / Diabetes Mellitus Tipo 1 / Rigidez Vascular / Contração Miocárdica Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Cardiovasc Imaging Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Holanda

Texto completo: 1 Temas: ECOS / Aspectos_gerais Bases de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Ecocardiografia Doppler / Função Ventricular Esquerda / Disfunção Ventricular Esquerda / Diabetes Mellitus Tipo 1 / Rigidez Vascular / Contração Miocárdica Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Cardiovasc Imaging Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Holanda