A multi-endpoint in vivo larval zebrafish (Danio rerio) model for the assessment of integrated cardiovascular function.

Parker, Thomas; Libourel, Paul-Antoine; Hetheridge, Malcolm J; Cumming, Robert I; Sutcliffe, Thomas P; Goonesinghe, Alexander C; Ball, Jonathan S; Owen, Stewart F; Chomis, Yann; Winter, Matthew J

Parker, Thomas; Libourel, Paul-Antoine; Hetheridge, Malcolm J; Cumming, Robert I; Sutcliffe, Thomas P; Goonesinghe, Alexander C; Ball, Jonathan S; Owen, Stewart F; Chomis, Yann; Winter, Matthew J.

Afiliação

Parker T; AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, United Kingdom.
Libourel PA; Centre de Recherche en Neurosciences de Lyon, Faculté de Médecine R.T.H. Laennec, 7 rue Guillaume Paradin, 69372 Lyon, France.
Hetheridge MJ; AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, United Kingdom.
Cumming RI; AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, United Kingdom.
Sutcliffe TP; AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, United Kingdom.
Goonesinghe AC; AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, United Kingdom.
Ball JS; AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, United Kingdom.
Owen SF; AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, United Kingdom.
Chomis Y; ViewPoint, 3 allée des Chevreuils, F-69380 Lissieu, France.
Winter MJ; AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, United Kingdom. Electronic address: matthew.winter@astrazeneca.com.

J Pharmacol Toxicol Methods ; 69(1): 30-8, 2014.

Article em En | MEDLINE | ID: mdl-24140389

Assuntos

Fármacos Cardiovasculares/efeitos adversos; Fármacos Cardiovasculares/farmacologia; Fenômenos Fisiológicos Cardiovasculares/efeitos dos fármacos; Sistema Cardiovascular/efeitos dos fármacos; Sistema Cardiovascular/fisiopatologia; Peixe-Zebra/fisiologia; Animais; Larva/efeitos dos fármacos; Modelos Animais; Fluxo Sanguíneo Regional/efeitos dos fármacos; Fluxo Sanguíneo Regional/fisiologia

Palavras-chave

ABR; AR; Alternative animal model; AV; BP; CV; Cardiovascular function; Cardiovascular pharmacology; DMSO; Drug discovery; Drug safety assessment; Frontloading; L-NAME; Larval zebrafish; MS222; MTC; Method; N (G)-nitro-l-arginine methyl ester; SC; SEM; SNP; SSV; VBR; VSMCs; Zf; adrenoreceptor; atrial beat rate; atrialventricular; beats per minute; blood pressure; bpm; cardiovascular; days post fertilization; dimethyl sulphoxide; dpf; fps; frames per second; hour post fertilization; hpf; maximum tolerated concentration; sodium nitroprusside; solvent control; standard error of the mean; surrogate stroke volume; tricaine methanesulfonate; vascular smooth muscle cells; ventricular beat rate; zebrafish

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Texto completo: 1 Temas: ECOS / Aspectos_gerais Bases de dados: MEDLINE Assunto principal: Peixe-Zebra / Fármacos Cardiovasculares / Sistema Cardiovascular / Fenômenos Fisiológicos Cardiovasculares Limite: Animals Idioma: En Revista: J Pharmacol Toxicol Methods Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Reino Unido

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