Assessment of the value of carcinoembryonic antigen reduction ratio as a prognosis factor in rectal cancer.
Am J Surg
; 208(1): 99-105, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-24524862
ABSTRACT
BACKGROUND:
Carcinoembryonic antigen (CEA) is the most widely used tumor marker for colorectal cancer. This study aimed to investigate the role of CEA reduction ratio after preoperative chemoradiotherapy (CRT).METHODS:
We enrolled 284 patients who underwent preoperative CRT followed by radical surgical resection. Patients were divided into 3 groups serum CEA levels before CRT (pre-CRT CEA) less than 5 ng/mL (group 1); pre-CRT CEA of 5 ng/mL or more with CEA reduction ratio of 50% or more (group 2); and pre-CRT CEA of 5 ng/mL or more with CEA reduction ratio less than 50% (group 3).RESULTS:
The 5-year disease-free survival (DFS) rate was not different between groups 1 (71.8%) and 2 (69.4%) but was signiï¬cantly lower in group 3 (49.5%). CEA group, lymph node status after CRT (ypN) stage, and histologic type were independent prognostic factors for DFS on multivariate analysis.CONCLUSIONS:
CEA reduction ratio might be an independent prognostic factor for DFS in rectal cancer patients treated with preoperative CRT and radical surgery.Palavras-chave
Texto completo:
1
Temas:
ECOS
/
Aspectos_gerais
Bases de dados:
MEDLINE
Assunto principal:
Neoplasias Retais
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Adenocarcinoma
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Antígeno Carcinoembrionário
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Quimiorradioterapia Adjuvante
Tipo de estudo:
Evaluation_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Am J Surg
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Taiwan