Optimization of b-value distribution for four mathematical models of prostate cancer diffusion-weighted imaging using b values up to 2000 s/mm(2): simulation and repeatability study.
Magn Reson Med
; 73(5): 1954-69, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25045885
ABSTRACT
PURPOSE:
To find optimal b-value distributions for monoexponential, stretched exponential, kurtosis, and biexponential models of prostate cancer (PCa) diffusion-weighted imaging (DWI) using simulations and repeated DWI examinations.METHODS:
Simulations aiming to minimize estimation accuracy error were performed. Ten PCa patients underwent in total four repeated 3-tesla DWI examinations using 12 equally spaced b values (0-2000 s/mm(2) ). Normalized mean signal intensities of regions-of-interest placed in normal tissue and PCa were fitted. In total, 210 different b-value combinations consisting of six b values, 0 and 100 s/mm(2) included in every b-value distribution, were evaluated in terms of accuracy and repeatability.RESULTS:
The simulations and in vivo DWI data suggest the optimal b-value distribution for the monoexponential model consists of four to five equally distributed b values in the range of 0 to 1200 s/mm(2) . The parameters of the stretched exponential and kurtosis models are best estimated using five to seven b values in the ranges of 300 to 700 and close to 2000 s/mm(2) , in addition to low b value. B-value distribution consisting of eight to 10 b values in the ranges of 0 to 100, 800 to 1200, and 1800 to 2000 s/mm(2) is the preferred method for estimation of the biexponential model parameters of PCa DWI.CONCLUSION:
The optimized b-value distributions demonstrated improved estimation accuracy and repeatability of DWI signal decay-derived parameters.Palavras-chave
Texto completo:
1
Temas:
ECOS
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Financiamentos_gastos
Bases de dados:
MEDLINE
Assunto principal:
Próstata
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Neoplasias da Próstata
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Interpretação de Imagem Assistida por Computador
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Imagens de Fantasmas
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Imagem de Difusão por Ressonância Magnética
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Modelos Teóricos
Tipo de estudo:
Health_economic_evaluation
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Prognostic_studies
Limite:
Humans
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Male
Idioma:
En
Revista:
Magn Reson Med
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Finlândia