Population pharmacokinetic-pharmacodynamic modeling and model-based prediction of docetaxel-induced neutropenia in Japanese patients with non-small cell lung cancer.

Fukae, Masato; Shiraishi, Yoshimasa; Hirota, Takeshi; Sasaki, Yuka; Yamahashi, Mika; Takayama, Koichi; Nakanishi, Yoichi; Ieiri, Ichiro

Fukae, Masato; Shiraishi, Yoshimasa; Hirota, Takeshi; Sasaki, Yuka; Yamahashi, Mika; Takayama, Koichi; Nakanishi, Yoichi; Ieiri, Ichiro.

Afiliação

Fukae M; Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Shiraishi Y; Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Hirota T; Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Sasaki Y; Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Yamahashi M; Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Takayama K; Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Nakanishi Y; Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Ieiri I; Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. ieiri-ttr@umin.ac.jp.

Cancer Chemother Pharmacol ; 78(5): 1013-1023, 2016 Nov.

Article em En | MEDLINE | ID: mdl-27709284

Assuntos

Antineoplásicos Fitogênicos/efeitos adversos; Carcinoma Pulmonar de Células não Pequenas/complicações; Neoplasias Pulmonares/complicações; Neutropenia/induzido quimicamente; Taxoides/efeitos adversos; Idoso; Antineoplásicos Fitogênicos/uso terapêutico; Povo Asiático; Carcinoma Pulmonar de Células não Pequenas/sangue; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Docetaxel; Feminino; Humanos; Contagem de Leucócitos; Neoplasias Pulmonares/sangue; Neoplasias Pulmonares/tratamento farmacológico; Masculino; Pessoa de Meia-Idade; Modelos Estatísticos; Método de Monte Carlo; Neutropenia/epidemiologia; Orosomucoide/análise; População; Valor Preditivo dos Testes; Estudos Prospectivos; Albumina Sérica/análise; Taxoides/uso terapêutico

Palavras-chave

Docetaxel; Modeling and simulation; NONMEM; Neutropenia; Pharmacometrics; pharmacokineticpharmacodynamic analysis

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Temas: ECOS / Financiamentos_gastos Bases de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Taxoides / Neoplasias Pulmonares / Neutropenia / Antineoplásicos Fitogênicos Tipo de estudo: Health_economic_evaluation / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Chemother Pharmacol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão

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