Assessment of novel cardiovascular biomarkers in women with a history of recurrent miscarriage.
Pregnancy Hypertens
; 11: 129-135, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-29102596
ABSTRACT
OBJECTIVES:
A history of recurrent miscarriage is associated with future cardiovascular disease. The aim of this study was to determine novel cardiovascular biomarkers in women with a history of recurrent miscarriage as this might lead to a better understanding of the association. STUDYDESIGN:
Women who visited the recurrent miscarriage clinic at Leiden University Medical Centre (between 2000 and 2010), and had three consecutive miscarriages ≤30â¯years were invited to participate in this follow-up study (between 2012 and 2014). The reference group consisted of women with at least one uncomplicated pregnancy and a history of no miscarriage, matched on zip code, age, and date of pregnancy. MAIN OUTCOMEMEASURES:
Cardiovascular biomarkers were determined, classified into; inflammation (HsCRP, lipoprotein-associated phospholipase A2), thrombosis (homocysteine, folate, anti-cardiolipin antibodies and anti-ß-2-glycoprotein antibodies), lipid metabolism (lipoprotein(a)), renal function (creatinine, microalbuminuria), myocardial damage (N-terminal pro-brain natriuretic peptide, high sensitive TroponineT) and multiple mechanisms (albumin, vitamin D).RESULTS:
In both groups, 36 women were included. Women with recurrent miscarriage had a significantly higher median HsCRP (1.49â¯mg/L) compared to women with no miscarriage (1.01â¯mg/L, pâ¯=â¯0.03) and a significantly lower mean albumin (46.0 vs 47.6g/L, pâ¯=â¯0.004) and vitamin D (55.6 vs 75.4nmol/L, pâ¯=â¯0.007), respectively. Differences remained after adjustments for classic cardiovascular risk factors (BMI, smoking, diabetes mellitus, and hypertension).CONCLUSIONS:
Our findings suggest a proinflammatory state in women with a history of recurrent miscarriage, which suggests a less optimal health, compared to women with no miscarriage. More research (observational and intervention) is warranted to investigate the association with vitamin D.Palavras-chave
Texto completo:
1
Temas:
ECOS
/
Aspectos_gerais
Bases de dados:
MEDLINE
Assunto principal:
Vitamina D
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Deficiência de Vitamina D
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Proteína C-Reativa
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Doenças Cardiovasculares
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Aborto Habitual
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Mediadores da Inflamação
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Hipoalbuminemia
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Albumina Sérica Humana
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Aspecto:
Patient_preference
Limite:
Adult
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Female
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Humans
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Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
Pregnancy Hypertens
Ano de publicação:
2018
Tipo de documento:
Article