Improved cost-effectiveness of short-course radiotherapy in elderly and/or frail patients with glioblastoma.
Radiother Oncol
; 127(1): 114-120, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29452901
ABSTRACT
BACKGROUND AND PURPOSE:
Short-course radiotherapy (25â¯Gy in five fractions) was recently shown in a randomized phase III trial to be non-inferior to 40â¯Gy in 15 fractions in elderly and/or frail patients with glioblastoma multiforme. This study compared the cost-effectiveness of the two regimens. MATERIAL ANDMETHODS:
The direct unit costs of imaging, radiotherapy (RT), and dexamethasone were collected from the five primary contributing countries to the trial, constituting the data of 88% of all patients. Effectiveness was measured by the restricted mean overall survival (RMOS) and progression free survival (RMPFS). The incremental cost-effectiveness ratio (ICER) was calculated. Indirect costs were also estimated for comparison.RESULTS:
The median OSs for the short-course and commonly used RTs were 8.2 (95% confidence interval [CI] 6.1-10.3) and 7.7 (95% CI 5.5-9.9) months, respectively (log rank pâ¯=â¯0.340). Median PFSs were also not different (pâ¯=â¯0.686). The differences in the RMOS and the ICER, however, were +0.11 life-years and -$3062 United States dollars (USD) per life-year gained, respectively. The differences in the RMPFS and the ICER were +0.02 PFS and -$17,693 USD, respectively.CONCLUSION:
The ICER of -$3062 per life-year gained and -$17,693 per PFS gained indicates that the short-course RT is less costly compared to the longer RT regimen.Palavras-chave
Texto completo:
1
Temas:
ECOS
/
Aspectos_gerais
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Financiamentos_gastos
Bases de dados:
MEDLINE
Assunto principal:
Custos de Cuidados de Saúde
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Glioblastoma
Tipo de estudo:
Clinical_trials
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Health_economic_evaluation
Aspecto:
Patient_preference
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Radiother Oncol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Canadá