Development of an Efficient and Cost-Effective Enzymatic Process for Production of (R)-[3,5-bis(trifluoromethyl)phenyl] Ethanol Using Carbonyl Reductase Derived from Leifsonia sp. S749.

Tang, Jiawei; Wei, Tengyun; Ni, Guowei; Guo, Xiang; Wu, Yuanjie; Zhang, Fuli; Chen, Shaoxin

Tang, Jiawei; Wei, Tengyun; Ni, Guowei; Guo, Xiang; Wu, Yuanjie; Zhang, Fuli; Chen, Shaoxin.

Afiliação

Tang J; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, China.
Wei T; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, China.
Ni G; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, China.
Guo X; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, China.
Wu Y; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, China.
Zhang F; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, China. zhangfuli1@sinopharm.com.
Chen S; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, China. chenshaoxin@sinopharm.com.

Appl Biochem Biotechnol ; 188(1): 87-100, 2019 May.

Article em En | MEDLINE | ID: mdl-30341711

Assuntos

Actinobacteria/enzimologia; Oxirredutases do Álcool/metabolismo; Análise Custo-Benefício; Álcool Feniletílico/análogos & derivados; Álcool Feniletílico/metabolismo; Oxirredutases do Álcool/química; Sequência de Aminoácidos; Reatores Biológicos; Biotransformação; Fermentação; Homologia de Sequência de Aminoácidos

Palavras-chave

(R)-[3,5-bis(trifluoromethyl)phenyl] ethanol; 3,5-bis(trifluoromethyl) acetophenone; Carbonyl reductase; Leifsonia sp.; Response surface methodology

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Texto completo: 1 Temas: ECOS / Aspectos_gerais / Financiamentos_gastos Bases de dados: MEDLINE Assunto principal: Álcool Feniletílico / Actinobacteria / Análise Custo-Benefício / Oxirredutases do Álcool Tipo de estudo: Health_economic_evaluation Idioma: En Revista: Appl Biochem Biotechnol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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