Systemic immune-inflammation index is a promising noninvasive marker to predict survival of lung cancer: A meta-analysis.
Medicine (Baltimore)
; 98(3): e13788, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-30653090
ABSTRACT
BACKGROUND:
The prognostic value of pretreatment systemic immune-inflammation index (SII) in lung cancer has yet to be fully established.METHODS:
Relevant articles were obtained by performing a systematic search. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were used to assess the relationship between SII index and overall survival (OS) in lung cancer; the OS was calculated from the time of cancer diagnosis to the date of death due to any cause or to the last date of follow-up.RESULTS:
In total, 2786 patients with lung cancer from 7 studies were included in this meta-analysis. The median thresholds to define high SII was 640 (range 395.4-1600) in the analyzed studies. The pooled HR for OS was 1.77 (95% CI 1.54-2.00, Pâ<â.001), suggesting that the patients with a high SII score had a worse OS. In addition, results from subgroup meta-analysis showed the significant prognostic significance of SII in lung cancer. Especially, the predictive value of SII was significant in the multivariable model for NSCLC (HR 1.97, 95% CI 1.69-2.25, Pâ<â.001; 5 studies, 1746 patients), and SCLC (HR 1.38, 95% CI 1.02-1.85, Pâ<â.001; 1 study, 919 patients).CONCLUSION:
Our data suggest that high SII index indicates poor survival rate in lung cancer. Further researches are warranted to verify the significance of SII index in clinical practice.
Texto completo:
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Temas:
ECOS
/
Aspectos_gerais
Bases de dados:
MEDLINE
Assunto principal:
Biomarcadores
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Carcinoma Pulmonar de Células não Pequenas
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Inflamação
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Neoplasias Pulmonares
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2019
Tipo de documento:
Article