Your browser doesn't support javascript.
loading
Developing a Clinico-Molecular Test for Individualized Treatment of Ovarian Cancer: The interplay of Precision Medicine Informatics with Clinical and Health Economics Dimensions.
Winterhoff, Boris; Kommoss, Stefan; Heitz, Florian; Konecny, Gottfried E; Dowdy, Sean C; Mullany, Sally A; Park-Simon, Tjoung-Won; Baumann, Klaus; Hilpert, Felix; Brucker, Sara; du Bois, Andreas; Schröder, Willibald; Burges, Alexander; Shen, Steven; Wang, Jinhua; Tourani, Roshan; Ma, Sisi; Pfisterer, Jacobus; Aliferis, Constantin F.
Afiliação
  • Winterhoff B; Department of Obstetrics, Gynecology and Women's Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, MN, USA.
  • Kommoss S; Institute for Health Informatics, University of Minnesota, MN, USA.
  • Heitz F; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
  • Konecny GE; Department of Women's Health, Tübingen University Hospital, Tübingen, Germany.
  • Dowdy SC; Kliniken Essen-Mitte, Gynäkologie und Gynäkologische Onkologie, Germany.
  • Mullany SA; Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA. USA.
  • Park-Simon TW; Mayo Clinic, Rochester, MN, USA.
  • Baumann K; Department of Obstetrics, Gynecology and Women's Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, MN, USA.
  • Hilpert F; Medizinische Hochschule Hannover, Gynäkologische Onkologie, Germany.
  • Brucker S; Universitätsklinikum Marburg, Klinik für Frauenheilkunde und Geburtshilfe , Germany.
  • du Bois A; Universitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Gynäkologie und Geburtshilfe, Germany.
  • Schröder W; Department of Women's Health, Tübingen University Hospital, Tübingen, Germany.
  • Burges A; Kliniken Essen-Mitte, Gynäkologie und Gynäkologische Onkologie, Germany.
  • Shen S; Klinikum Bremen-Mitte, Frauenklinik Gynaekologicum Bremen; Willibald, Germany.
  • Wang J; Klinikum der Universität München - LMU, Campus Großhadern, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Germany.
  • Tourani R; Institute for Health Informatics, University of Minnesota, MN, USA.
  • Ma S; Institute for Health Informatics, University of Minnesota, MN, USA.
  • Pfisterer J; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
  • Aliferis CF; Institute for Health Informatics, University of Minnesota, MN, USA.
AMIA Annu Symp Proc ; 2018: 1093-1102, 2018.
Article em En | MEDLINE | ID: mdl-30815151
ABSTRACT
We report recent progress in the development of a precision test for individualized use of the VEGF-A targeting drug bevacizumab for treating ovarian cancer. We discuss the discovery model stage (i.e., past feasibility modeling and before conversion to the production test). Main

results:

(a) Informatics modeling plays a critical role in supporting driving clinical and health economic requirements. (b) The novel computational models support the creation of a precision test with sufficient predictivity to reduce healthcare system costs up to $30 billion over 10 years, and make the use of bevacizumab affordable without loss of length or quality of life.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Temas: ECOS / Aspectos_gerais Bases de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Terapia Assistida por Computador / Biologia Computacional / Medicina de Precisão / Terapia de Alvo Molecular / Bevacizumab / Antineoplásicos Imunológicos / Carcinoma Epitelial do Ovário Tipo de estudo: Health_economic_evaluation / Prognostic_studies Aspecto: Patient_preference Limite: Female / Humans Idioma: En Revista: AMIA Annu Symp Proc Assunto da revista: INFORMATICA MEDICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Temas: ECOS / Aspectos_gerais Bases de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Terapia Assistida por Computador / Biologia Computacional / Medicina de Precisão / Terapia de Alvo Molecular / Bevacizumab / Antineoplásicos Imunológicos / Carcinoma Epitelial do Ovário Tipo de estudo: Health_economic_evaluation / Prognostic_studies Aspecto: Patient_preference Limite: Female / Humans Idioma: En Revista: AMIA Annu Symp Proc Assunto da revista: INFORMATICA MEDICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos