Stereoselective total synthesis of Patulolide C.

Pratapareddy, Bommareddy; Sreenivasulu, Reddymasu; Rao, Mandava Venkata Basaveswara; Raju, Rudraraju Ramesh

Pratapareddy, Bommareddy; Sreenivasulu, Reddymasu; Rao, Mandava Venkata Basaveswara; Raju, Rudraraju Ramesh.

Afiliação

Pratapareddy B; Department of Chemistry, Krishna University , Machilipatnam , Andhra Pradesh , India.
Sreenivasulu R; Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University , Kakinada , Andhra Pradesh , India.
Rao MVB; Department of Chemistry, Krishna University , Machilipatnam , Andhra Pradesh , India.
Raju RR; Department of Chemistry, Acharya Nagarjuna University , Andhra Pradesh , India.

Nat Prod Res ; 34(19): 2760-2764, 2020 Oct.

Article em En | MEDLINE | ID: mdl-31250664

ABSTRACT

ABSTRACT

Stereoselective total synthesis of Patulolide C has been accomplished from easily available and inexpensive (S)-chiral epoxide. The key steps involved in the concise synthesis of Patulolide C utilizes ring opening of chiral epoxide, cleavage of 1,2-diol, deprotection of benzyl ether of hydroxyl acid and Yamaguchi macrolactonisation dilution conditions as key steps. The advantage of this method include inexpensive starting material, mild reaction conditions and high purity of products.

Assuntos

Compostos de Epóxi/química; Macrolídeos/síntese química; Técnicas de Química Sintética/economia; Técnicas de Química Sintética/métodos; Estereoisomerismo

Palavras-chave

(S)-chiral epoxide; 1,2-diol cleavage; Patulolide C; ring opening of chiral epoxide; stereoselective total synthesis

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Texto completo: 1 Temas: ECOS / Aspectos_gerais Bases de dados: MEDLINE Assunto principal: Macrolídeos / Compostos de Epóxi Idioma: En Revista: Nat Prod Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Índia

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