Complex Economic Behavior Patterns Are Constructed from Finite, Genetically Controlled Modules of Behavior.
Cell Rep
; 28(7): 1814-1829.e6, 2019 08 13.
Article
em En
| MEDLINE
| ID: mdl-31412249
ABSTRACT
Complex ethological behaviors could be constructed from finite modules that are reproducible functional units of behavior. Here, we test this idea for foraging and develop methods to dissect rich behavior patterns in mice. We uncover discrete modules of foraging behavior reproducible across different strains and ages, as well as nonmodular behavioral sequences. Modules differ in terms of form, expression frequency, and expression timing and are expressed in a probabilistically determined order. Modules shape economic patterns of feeding, exposure, activity, and perseveration responses. The modular architecture of foraging changes developmentally, and different developmental, genetic, and parental effects are found to shape the expression of specific modules. Dissecting modules from complex patterns is powerful for phenotype analysis. We discover that both parental alleles of the imprinted Prader-Willi syndrome gene Magel2 are functional in mice but regulate different modules. Our study found that complex economic patterns are built from finite, genetically controlled modules.
Palavras-chave
Texto completo:
1
Temas:
ECOS
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Aspectos_gerais
Bases de dados:
MEDLINE
Assunto principal:
Síndrome de Prader-Willi
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Comportamento Animal
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Encéfalo
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Proteínas
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Regulação da Expressão Gênica no Desenvolvimento
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Redes Reguladoras de Genes
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Antígenos de Neoplasias
Tipo de estudo:
Health_economic_evaluation
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Cell Rep
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos