Non-invasive assessment of temporal changes in myocardial microvascular function in persons with type 2 diabetes and healthy controls.
Diabet Med
; 38(6): e14517, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-33434331
ABSTRACT
BACKGROUND:
Cardiac Rubidium-82 (82 Rb) positron emission tomography/computed tomography (PET/CT) provides a measure of the myocardial blood flow and the myocardial flow reserve, which reflects the function of both large epicardial arteries and the myocardial microcirculation. Knowledge on changes in the myocardial microvascular function over time is lacking.METHODS:
In this cohort study, we recruited 60 persons with type 2 diabetes and 30 non-diabetic controls, in 2013; all free of overt cardiovascular disease. All underwent a cardiac 82 Rb PET/CT scan. In 2019, all survivors (n = 82) were invited for a repeated cardiac 82 Rb PET/CT scan using the same protocol, and 29 with type 2 diabetes and 19 controls participated.RESULTS:
Median duration between visits was 6.2 years (IQR 6.1-6.3). In the total cohort, the mean age was 66.4 years (SD 9.3) and 33% were females. The myocardial flow reserve was lower in persons with type 2 diabetes compared to controls (p = 0.002) but there was no temporal change in the myocardial flow reserve in participants with type 2 diabetes mean change -0.22 (95% CI -0.47 to 0.02) nor in controls -0.12 (-0.49 to 0.25) or when comparing type 2 diabetes to controls mean difference -0.10 (95% CI -0.52 to 0.31). The temporal reduction in stress-induced myocardial blood flow did not differ within the groups but was more pronounced in type 2 diabetes compared to controls mean difference -0.30 (95% CI -0.55 to -0.04).CONCLUSION:
The myocardial microvascular function was impaired in persons with type 2 diabetes compared to controls but did not change significantly in either of the groups when evaluated over 6 years.Palavras-chave
Texto completo:
1
Temas:
ECOS
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Aspectos_gerais
Bases de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
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Circulação Coronária
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Diabetes Mellitus Tipo 2
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Microcirculação
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Diabet Med
Assunto da revista:
ENDOCRINOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Dinamarca