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Assessment of Mitochondrial Reactive Oxygen Species and Redox Regulation in Stem Cells.
Thumiah-Mootoo, Madhavee; Podinic, Tina; Khacho, Mireille.
Afiliação
  • Thumiah-Mootoo M; Department of Cellular & Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
  • Podinic T; Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology (OISB), Center for Neuromuscular Disease, University of Ottawa, Ottawa, ON, Canada.
  • Khacho M; Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology (OISB), Center for Neuromuscular Disease, University of Ottawa, Ottawa, ON, Canada. mkhacho@uottawa.ca.
Methods Mol Biol ; 2277: 289-297, 2021.
Article em En | MEDLINE | ID: mdl-34080158
ABSTRACT
Mitochondrial reactive oxygen species (mtROS) and redox regulation play an important role in stem cell maintenance and cell fate decisions. Although changes in mtROS and redox homeostasis represent a physiological mechanism to drive stem cell commitment and differentiation, dysregulation of this system can lead to defects in stem cell maintenance and regenerative capacity. This chapter explains the methods used to assess mitochondrial superoxide levels and redox regulation in stem cell populations.
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Texto completo: 1 Temas: ECOS / Aspectos_gerais Bases de dados: MEDLINE Assunto principal: Células-Tronco / Espécies Reativas de Oxigênio / Mitocôndrias Limite: Animals Idioma: En Revista: Methods Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Temas: ECOS / Aspectos_gerais Bases de dados: MEDLINE Assunto principal: Células-Tronco / Espécies Reativas de Oxigênio / Mitocôndrias Limite: Animals Idioma: En Revista: Methods Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá