Use of in vitro metabolism and biokinetics assays to refine predicted in vivo and in vitro internal exposure to the cosmetic ingredient, phenoxyethanol, for use in risk assessment.

Hewitt, Nicola J; Troutman, John; Przibilla, Julia; Schepky, Andreas; Ouédraogo, Gladys; Mahony, Catherine; Kenna, Gerry; Varçin, Mustafa; Dent, Mathew P

Hewitt, Nicola J; Troutman, John; Przibilla, Julia; Schepky, Andreas; Ouédraogo, Gladys; Mahony, Catherine; Kenna, Gerry; Varçin, Mustafa; Dent, Mathew P.

Afiliação

Hewitt NJ; Cosmetics Europe, Avenue Herrmann-Debroux 40, 1160, Auderghem, Belgium.
Troutman J; The Procter & Gamble Company, Cincinnati, USA.
Przibilla J; Pharmacelsus GmbH, Science Park 2, D-66123, Saarbrücken, Germany.
Schepky A; Beiersdorf AG, Hamburg, Germany.
Ouédraogo G; L'Oréal, Research & Innovation, 9 rue Pierre Dreyfus, 92110, Clichy, France.
Mahony C; Procter & Gamble Technical Centres Ltd, Reading, RG2 0RX, UK.
Kenna G; Drug Safety Consultant, 2 Farmfield Drive, Macclesfield, Cheshire, SK10 2TJ, UK.
Varçin M; Cosmetics Europe, Avenue Herrmann-Debroux 40, 1160, Auderghem, Belgium.
Dent MP; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK.

Regul Toxicol Pharmacol ; 131: 105132, 2022 Jun.

Article em En | MEDLINE | ID: mdl-35217105

Assuntos

Cosméticos; Etilenoglicóis; Cosméticos/toxicidade; Etilenoglicóis/toxicidade; Humanos; Medição de Risco

Palavras-chave

IVIVE; In vitro biokinetics; In vitro models; Phenoxyethanol; Safety assessment

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Texto completo: 1 Temas: ECOS / Aspectos_gerais Bases de dados: MEDLINE Assunto principal: Cosméticos / Etilenoglicóis Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Bélgica

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