Human risk assessment of 4-n-nonylphenol (4-n-NP) using physiologically based pharmacokinetic (PBPK) modeling: analysis of gender exposure differences and application to exposure analysis related to large exposure variability in population.

Jeong, Seung-Hyun; Jang, Ji-Hun; Cho, Hea-Young; Lee, Yong-Bok

Jeong, Seung-Hyun; Jang, Ji-Hun; Cho, Hea-Young; Lee, Yong-Bok.

Afiliação

Jeong SH; College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.
Jang JH; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.
Cho HY; College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.
Lee YB; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.

Arch Toxicol ; 96(10): 2687-2715, 2022 10.

Article em En | MEDLINE | ID: mdl-35723719

Assuntos

Modelos Biológicos; Fenóis; Feminino; Humanos; Masculino; Fenóis/farmacocinética; Fenóis/toxicidade; Medição de Risco; Fatores Sexuais

Palavras-chave

4-n-nonylphenol (4-n-NP); Exposure analysis; Exposure variability; Gender differences; Human risk assessment; Physiologically based pharmacokinetic (PBPK) model

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Texto completo: 1 Temas: ECOS / Aspectos_gerais Bases de dados: MEDLINE Assunto principal: Fenóis / Modelos Biológicos Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Female / Humans / Male Idioma: En Revista: Arch Toxicol Ano de publicação: 2022 Tipo de documento: Article

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