Neuroendocrine differentiation in the setting of prostatic carcinoma: contemporary assessment of a consecutive series.
Histopathology
; 81(2): 246-254, 2022 Aug.
Article
em En
| MEDLINE
| ID: mdl-35758203
ABSTRACT
AIM:
Clinicopathologic characterisation of a contemporary series of neuroendocrine (NE) differentiation in the setting of prostatic carcinoma (PCa) was examined. METHODS ANDRESULTS:
We reviewed institutional databases for in-house cases with a history of PCa and histopathologic evidence of NE differentiation during the disease course. In all, 79 cases were identified 32 primary and 47 metastases. Metastatic lesions were in liver (n = 15), lymph node (n = 9), bone (n = 6), lung (n = 3), brain (n = 1), and other sites (n = 13). In all, 63 of 76 (82%) cases with NE differentiation and available history were posttherapy six postradiation therapy (RT), 24 post- androgen-deprivation therapy (ADT), and 33 post-RT + ADT. Morphologic assessment (n = 79) (i) 23 pure small-cell/high-grade NE carcinoma (HGNEC) 20/23 metastatic; (ii) 10 combined high-grade PCa and small-cell/HGNEC 9/10 primary; (iii) 15 PCa with diffuse NE immunohistochemistry (IHC) marker positivity/differentiation, associated with nested to sheet-like growth of cells with abundant cytoplasm and prominent nucleoli, yet diffuse positivity for at least one prostatic and one NE IHC marker all metastatic; (iv) 11 PCa with patchy NE differentiation, displaying more than single-cell positivity for NE IHC five primary / six metastatic; (v) nine PCa with focal NE marker positive cells four primary / five metastatic; (vi) 11 PCa with 'Paneth cell-like' change all primary.CONCLUSIONS:
In this contemporary series, the majority of NE differentiation in the setting of PCa was seen posttherapy. We highlight the tendencies of small-cell/HGNEC and PCa with diffuse NE differentiation by IHC to occur in metastatic settings, while morphologically combined high-grade PCa + small-cell/HGNEC and 'Paneth cell-like' change occur in primary disease.Palavras-chave
Texto completo:
1
Temas:
ECOS
/
Aspectos_gerais
Bases de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
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Carcinoma de Células Pequenas
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Carcinoma Neuroendócrino
Tipo de estudo:
Prognostic_studies
Limite:
Humans
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Male
Idioma:
En
Revista:
Histopathology
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos