Higher native Peruvian genetic ancestry proportion is associated with tuberculosis progression risk.
Cell Genom
; 2(7)2022 Jul 13.
Article
em En
| MEDLINE
| ID: mdl-35873671
ABSTRACT
We investigated whether ancestry-specific genetic factors affect tuberculosis (TB) progression risk in a cohort of admixed Peruvians. We genotyped 2,105 patients with TB and 1,320 household contacts (HHCs) who were infected with Mycobacterium tuberculosis (M. tb) but did not develop TB and inferred each individual's proportion of native Peruvian genetic ancestry. Our HHC study design and our data on potential confounders allowed us to demonstrate increased risk independent of socioeconomic factors. A 10% increase in individual-level native Peruvian genetic ancestry proportion corresponded to a 25% increased TB progression risk. This corresponds to a 3-fold increased risk for individuals in the highest decile of native Peruvian genetic ancestry versus the lowest decile, making native Peruvian genetic ancestry comparable in effect to clinical factors such as diabetes. Our results suggest that genetic ancestry is a major contributor to TB progression risk and highlight the value of including diverse populations in host genetic studies.
Texto completo:
1
Temas:
ECOS
/
Equidade_desigualdade
Bases de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Aspecto:
Equity_inequality
Idioma:
En
Revista:
Cell Genom
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos