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Higher native Peruvian genetic ancestry proportion is associated with tuberculosis progression risk.
Asgari, Samira; Luo, Yang; Huang, Chuan-Chin; Zhang, Zibiao; Calderon, Roger; Jimenez, Judith; Yataco, Rosa; Contreras, Carmen; Galea, Jerome T; Lecca, Leonid; Jones, David; Moody, D Branch; Murray, Megan B; Raychaudhuri, Soumya.
Afiliação
  • Asgari S; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Luo Y; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Huang CC; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Zhang Z; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Calderon R; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
  • Jimenez J; Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Yataco R; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Contreras C; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Galea JT; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Lecca L; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Jones D; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
  • Moody DB; Department of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA.
  • Murray MB; Division of Global Health Equity, Brigham and Women's Hospital, Boston, MA, USA.
  • Raychaudhuri S; Department of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA.
Cell Genom ; 2(7)2022 Jul 13.
Article em En | MEDLINE | ID: mdl-35873671
ABSTRACT
We investigated whether ancestry-specific genetic factors affect tuberculosis (TB) progression risk in a cohort of admixed Peruvians. We genotyped 2,105 patients with TB and 1,320 household contacts (HHCs) who were infected with Mycobacterium tuberculosis (M. tb) but did not develop TB and inferred each individual's proportion of native Peruvian genetic ancestry. Our HHC study design and our data on potential confounders allowed us to demonstrate increased risk independent of socioeconomic factors. A 10% increase in individual-level native Peruvian genetic ancestry proportion corresponded to a 25% increased TB progression risk. This corresponds to a 3-fold increased risk for individuals in the highest decile of native Peruvian genetic ancestry versus the lowest decile, making native Peruvian genetic ancestry comparable in effect to clinical factors such as diabetes. Our results suggest that genetic ancestry is a major contributor to TB progression risk and highlight the value of including diverse populations in host genetic studies.
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Texto completo: 1 Temas: ECOS / Equidade_desigualdade Bases de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies Aspecto: Equity_inequality Idioma: En Revista: Cell Genom Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Temas: ECOS / Equidade_desigualdade Bases de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies Aspecto: Equity_inequality Idioma: En Revista: Cell Genom Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos