Self-Assembling Lecithin-Based Mixed Polymeric Micelles for Nose to Brain Delivery of Clozapine: In-vivo Assessment of Drug Efficacy via Radiobiological Evaluation.

M Elsharkawy, Fatma; M Amin, Maha; A Shamsel-Din, Hesham; Ibrahim, Walaa; Ibrahim, Ahmed B; Sayed, Sinar

M Elsharkawy, Fatma; M Amin, Maha; A Shamsel-Din, Hesham; Ibrahim, Walaa; Ibrahim, Ahmed B; Sayed, Sinar.

Afiliação

M Elsharkawy F; Regulatory Affairs Department, Al Andalous for Pharmaceutical Industries, Giza, Egypt.
M Amin M; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
A Shamsel-Din H; Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo, 13759, Egypt.
Ibrahim W; Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo, 13759, Egypt.
Ibrahim AB; Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo, 13759, Egypt.
Sayed S; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Int J Nanomedicine ; 18: 1577-1595, 2023.

Article em En | MEDLINE | ID: mdl-37007986

Assuntos

Clozapina; Micelas; Radioisótopos do Iodo; Clozapina/metabolismo; Lecitinas; Distribuição Tecidual; Sistemas de Liberação de Medicamentos/métodos; Administração Intranasal; Encéfalo; Mucosa Nasal/metabolismo; Polímeros/química; Tamanho da Partícula; Portadores de Fármacos/química

Palavras-chave

131I; brain targeting; clozapine; intranasal route; radioiodinated clozapine; self-assembling polymeric micelles; soy lecithin

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Texto completo: 1 Temas: ECOS / Aspectos_gerais Bases de dados: MEDLINE Assunto principal: Clozapina / Micelas Idioma: En Revista: Int J Nanomedicine Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Egito

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