Optimization of Voriconazole Dosing Regimens Against Aspergillus Species and Candida Species in Pediatric Patients After Hematopoietic Cell Transplantation: A Theoretical Study Based on Pharmacokinetic/Pharmacodynamic Analysis.

Xie, Mengyuan; Jiang, Manxue; Qiu, Hongyu; Rong, Li; Kong, Lingti

Xie, Mengyuan; Jiang, Manxue; Qiu, Hongyu; Rong, Li; Kong, Lingti.

Afiliação

Xie M; Department of Pharmacy, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Jiang M; School of Pharmacy, Bengbu Medical College, Bengbu, China.
Qiu H; Department of Pharmacy, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Rong L; School of Pharmacy, Bengbu Medical College, Bengbu, China.
Kong L; Department of Pharmacy, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.

J Clin Pharmacol ; 63(9): 993-1001, 2023 09.

Article em En | MEDLINE | ID: mdl-37083934

Assuntos

Antifúngicos; Transplante de Células-Tronco Hematopoéticas; Humanos; Criança; Voriconazol; Candida; Citocromo P-450 CYP2C19/genética; Aspergillus; Método de Monte Carlo; Testes de Sensibilidade Microbiana; Modelos Teóricos; Peso Corporal

Palavras-chave

CYP2C19; Monte Carlo simulations; body weights; invasive fungal infections; pharmacokinetic/pharmacodynamic; voriconazole

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Texto completo: 1 Temas: ECOS / Financiamentos_gastos Bases de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Antifúngicos Limite: Child / Humans Idioma: En Revista: J Clin Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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