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Range verification of a clinical proton beam in an abdominal phantom by co-registration of ionoacoustics and ultrasound.
Schauer, Jannis; Wieser, Hans-Peter; Lascaud, Julie; Huang, Yuanhui; Vidal, Marie; Herault, Joel; Ntziachristos, Vasilis; Dollinger, Günther; Parodi, Katia.
Afiliação
  • Schauer J; Institute for Applied Physics and Metrology, Bundeswehr University Munich, D-85577 Neubiberg, Germany.
  • Wieser HP; Faculty of Physics, Chair of Medical and Experimental Physics, Ludwig-Maximilians-University, D-85748 Garching b. München, Germany.
  • Lascaud J; Faculty of Physics, Chair of Medical and Experimental Physics, Ludwig-Maximilians-University, D-85748 Garching b. München, Germany.
  • Huang Y; Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum Mnchen, D-85764 Neuherberg, Germany.
  • Vidal M; Chair of Biological Imaging for Translational Cancer Research (TranslaTUM), School of Medicine, Technical Univerity of Munich, D-81675 Munich, Germany.
  • Herault J; Centre Antoine Lacassagne (CAL), F-06200 Nice, France.
  • Ntziachristos V; Centre Antoine Lacassagne (CAL), F-06200 Nice, France.
  • Dollinger G; Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum Mnchen, D-85764 Neuherberg, Germany.
  • Parodi K; Chair of Biological Imaging for Translational Cancer Research (TranslaTUM), School of Medicine, Technical Univerity of Munich, D-81675 Munich, Germany.
Phys Med Biol ; 68(12)2023 06 13.
Article em En | MEDLINE | ID: mdl-37220766
ABSTRACT
Objective.The range uncertainty in proton radiotherapy is a limiting factor to achieve optimum dose conformity to the tumour volume. Ionoacoustics is a promising approach forin siturange verification, which would allow to reduce the size of the irradiated volume relative to the tumour volume. The energy deposition of a pulsed proton beam leads to an acoustic pressure wave (ionoacoustics), the detection of which allows conclusion about the distance between the Bragg peak and the acoustic detector. This information can be transferred into a co-registered ultrasound image, marking the Bragg peak position relative to the surrounding anatomy.Approach.A CIRS 3D abdominal phantom was irradiated with 126 MeV protons at a clinical proton therapy centre. Acoustic signals were recorded on the beam axis distal to the Bragg peak with a Cetacean C305X hydrophone. The ionoacoustic measurements were processed with a correlation filter using simulated filter templates. The hydrophone was rigidly attached to an ultrasound device (Interson GP-C01) recording ultrasound images of the irradiated region.Main results.The time of flight obtained from ionoacoustic measurements were transferred to an ultrasound image by means of an optoacoustic calibration measurement. The Bragg peak position was marked in the ultrasound image with a statistical uncertainty ofσ= 0.5 mm of 24 individual measurements depositing 1.2 Gy at the Bragg peak. The difference between the evaluated Bragg peak position and the one obtained from irradiation planning (1.0 mm) is smaller than the typical range uncertainty (≈4 mm) at the given penetration depth (10 cm).Significance.The measurements show that it is possible to determine the Bragg peak position of a clinical proton beam with submillimetre precision and transfer the information to an ultrasound image of the irradiated region. The dose required for this is smaller than that used for a typical irradiation fraction.
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Texto completo: 1 Temas: ECOS / Financiamentos_gastos Bases de dados: MEDLINE Assunto principal: Prótons / Terapia com Prótons Tipo de estudo: Health_economic_evaluation Idioma: En Revista: Phys Med Biol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Temas: ECOS / Financiamentos_gastos Bases de dados: MEDLINE Assunto principal: Prótons / Terapia com Prótons Tipo de estudo: Health_economic_evaluation Idioma: En Revista: Phys Med Biol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha