A comprehensive review and shiny application on the matching-adjusted indirect comparison.
Res Synth Methods
; 15(4): 671-686, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38380799
ABSTRACT
Population-adjusted indirect comparison (PAIC) is an increasingly used technique for estimating the comparative effectiveness of different treatments for the health technology assessments when head-to-head trials are unavailable. Three commonly used PAIC methods include matching-adjusted indirect comparison (MAIC), simulated treatment comparison (STC), and multilevel network meta-regression (ML-NMR). MAIC enables researchers to achieve balanced covariate distribution across two independent trials when individual participant data are only available in one trial. In this article, we provide a comprehensive review of the MAIC methods, including their theoretical derivation, implicit assumptions, and connection to calibration estimation in survey sampling. We discuss the nuances between anchored and unanchored MAIC, as well as their required assumptions. Furthermore, we implement various MAIC methods in a user-friendly R Shiny application Shiny-MAIC. To our knowledge, it is the first Shiny application that implements various MAIC methods. The Shiny-MAIC application offers choice between anchored or unanchored MAIC, choice among different types of covariates and outcomes, and two variance estimators including bootstrap and robust standard errors. An example with simulated data is provided to demonstrate the utility of the Shiny-MAIC application, enabling a user-friendly approach conducting MAIC for healthcare decision-making. The Shiny-MAIC is freely available through the link https//ziren.shinyapps.io/Shiny_MAIC/.
Palavras-chave
Texto completo:
1
Temas:
ECOS
/
Avaliacao_tecnologia
Bases de dados:
MEDLINE
Assunto principal:
Algoritmos
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Simulação por Computador
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Pesquisa Comparativa da Efetividade
Limite:
Humans
Idioma:
En
Revista:
Res Synth Methods
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos