Universal screening and treatment towards the elimination of chronic hepatitis C in China: an economic evaluation.
Public Health
; 228: 186-193, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38387115
ABSTRACT
OBJECTIVES:
China has the largest number of hepatitis C virus (HCV) infection in the world, but current levels of diagnosis and treatment are low. The objective of this study was to assess the cost-effectiveness of various universal HCV screening and treatment strategies in China and inform decisions on health policy. STUDYDESIGN:
A cost-effectiveness analytical study.METHODS:
We developed a Markov model to investigate cost-effectiveness of different HCV screening and treatment strategies in China. We simulated several screening scenarios for Chinese people aged 18-70 years. We estimated incremental cost-effectiveness ratios (ICERs) of different intervention scenarios compared with status quo.RESULTS:
Expanded HCV screening and treatment strategy with prioritisation for high-risk groups (Scenario S5) was the most cost-effective strategy (ICER USD $11,667.71/quality-adjusted life-year [QALY] gained), which resulted in great reduction in HCV-related diseases and deaths, with a 67.11% reduction in cases of chronic HCV. Universal HCV screening and treatment implementation remains a cost-effective strategy when delayed until 2025 (ICER USD $17,093.69/QALY), yet the delayed strategy is less effective in reducing HCV-related deaths.CONCLUSIONS:
Expanded HCV screening and treatment strategy with prioritisation for high-risk groups is the most cost-effective strategy and has lead to a significant reduction in both HCV morbidity and mortality in China, which would essentially eliminate HCV as a public threat.Palavras-chave
Texto completo:
1
Temas:
ECOS
/
Aspectos_gerais
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Avaliacao_economica
Bases de dados:
MEDLINE
Assunto principal:
Programas de Rastreamento
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Hepatite C Crônica
Limite:
Adolescent
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Adult
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Aged
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Humans
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Public Health
Ano de publicação:
2024
Tipo de documento:
Article