Pharmaceutical innovativeness index: methodological approach for assessing the value of medicines - a case study of oncology drugs.
Expert Rev Pharmacoecon Outcomes Res
; 24(8): 977-986, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-38859799
ABSTRACT
BACKGROUND:
We propose a framework to assess the value of pharmaceutical innovations, with explicit clinical and methodological parameters, based on the therapeutic value and health needs. RESEARCH DESIGN ANDMETHODS:
The study was based on the adaptation of health technology assessment methods documented in the literature, which was applied to a sample of oncological drugs. Difficulties and issues during the application of those tools were identified and addressed to develop a new framework with new and revised domains and clear classification criterion for each domain. Scores were assigned to each level and domain according to their relevance to generate the final score of innovativeness.RESULTS:
The Pharmaceutical Innovation Index (PII) includes four domains, two related to clinical and social dimensions - Therapeutic Need and Added Therapeutic Value - and other two about methodological features - Study Design and Quality (risk of bias). The scores combined after assigned to each domain results Index of the Innovativeness of the medicines represents the degree of pharmaceutical innovation.CONCLUSION:
This work proposes a transparent methodology with well-defined criteria and script; the algorithm developed with authors' weightings and criteria may be switched to best adjust to other applications, perspective or clinical indications, while keeping the transparency and objectiveness.Palavras-chave
Texto completo:
1
Temas:
ECOS
/
Avaliacao_tecnologia
Bases de dados:
MEDLINE
Assunto principal:
Projetos de Pesquisa
/
Avaliação da Tecnologia Biomédica
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Algoritmos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Expert Rev Pharmacoecon Outcomes Res
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Brasil