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[The Value of Clinical Characteristics and Hematological Parameters for Prognostic Assessment of Pancreatic Cancer Patients Undergoing Radical Resection]. / 一般临床特征与血液学参数在胰腺导管腺癌根治性切除术患者中的预后价值研究.
Zeng, Lianli; Li, Shuangshuang; Yue, Pengfei; Yi, Cheng.
Afiliação
  • Zeng L; ( 610041) Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Li S; ( 610041) Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Yue P; ( 610041) Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Yi C; ( 610041) Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 55(3): 708-716, 2024 May 20.
Article em Zh | MEDLINE | ID: mdl-38948268
ABSTRACT

Objective:

To explore the relationship between baseline clinical characteristics and hematological parameters of patients undergoing radical resection for pancreatic ductal adenocarcinoma (PDAC) and their prognosis, and to provide references for stratifying the patients' clinical risks.

Methods:

We retrospectively collected clinical data from 445 patients who underwent radical surgical treatment for PDAC at West China Hospital, Sichuan University between January 2010 and February 2019. Then, we conducted retrospective clinical analysis with the collected data. Data on patients' basic clinical characteristics, routine blood test results, and tumor indicators were collected to explore their effects on the postoperative overall survival (OS) of PDAC patients. Cox proportional hazards regression was used to identify factors affecting OS. Statistical analysis was performed using the SPSS 23.0 software package.

Results:

The postoperative median overall survival (mOS) was 17.0 months (95% CI 15.0-19.0). The 1, 2, 3, 4, and 5-year survival rates of the patients included in the study were 60.6%, 33.4%, 19.1%, 12.7%, and 9.6%, respectively. The multivariate Cox proportional hazards model analysis demonstrated that a number of factors independently affect postoperative survival in PDAC patients. These factors include tumor location (hazards ratio [HR]=1.574, 95% CI 1.233-2.011), degree of tumor cell differentiation (HR=0.687, 95% CI 0.542-0.870), presence of neural invasion (HR=0.686, 95% CI 0.538-0.876), TNM staging (HR=1.572, 95% CI 1.252-1.974), postoperative adjuvant therapy (HR=1.799, 95% CI 1.390-2.328), preoperative drinking history (HR=0.744, 95% CI 0.588-0.943), and high serum CA199 levels prior to the surgery (HR=0.742, 95% CI 0.563-0.977).

Conclusion:

In PDAC patients, having tumors located in the head of the pancreas, moderate and high degrees of differentiated, being free from local neurovascular invasion, being in TNM stage Ⅰ, undergoing postoperative adjuvant therapy, no history of alcohol consumption prior to the surgery, and preoperative serum CA199 being less than or equal to 37 U/mL are significantly associated with a better prognosis.
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Texto completo: 1 Temas: ECOS / Aspectos_gerais Bases de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: Zh Revista: Sichuan Da Xue Xue Bao Yi Xue Ban Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Temas: ECOS / Aspectos_gerais Bases de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: Zh Revista: Sichuan Da Xue Xue Bao Yi Xue Ban Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China