A neo-Darwinian algorithm: asymmetrical mutations due to semiconservative DNA-type replication promote evolution.
Proc Natl Acad Sci U S A
; 90(24): 11934-8, 1993 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-8265651
ABSTRACT
Evolution is, in a sense, to resolve optimization problems. Our neo-Darwinian algorithm based on the mechanics of inheritance and natural selection uses double-stranded DNA-type genetic information to resolve the "knap-sack problem." The algorithm with asymmetrical mutations due to semiconservative DNA-type replication most effectively resolved the problem. Our results strongly suggest that disparity in mutations caused by the asymmetric machinery of DNA replication promotes evolution, in particular of diploid organisms with a high mutation rate, in a small population, and under strong selection pressure.
Texto completo:
1
Temas:
ECOS
/
Financiamentos_gastos
Bases de dados:
MEDLINE
Assunto principal:
Algoritmos
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Replicação do DNA
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Evolução Biológica
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Modelos Biológicos
Tipo de estudo:
Health_economic_evaluation
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Prognostic_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
1993
Tipo de documento:
Article