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1.
Assessing the in vivo efficacy of rational antibiotics and combinations against difficult-to-treat Pseudomonas aeruginosa producing GES ß-lactamases.
J Antimicrob Chemother
; 78(8): 1843-1847, 2023 08 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37357368
2.
Pharmacokinetics and soft-tissue distribution of tebipenem pivoxil hydrobromide using microdialysis: a study in healthy subjects and patients with diabetic foot infections.
J Antimicrob Chemother
; 78(1): 296-301, 2022 12 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36424364
3.
Plasma and cerebrospinal fluid concentrations of cefiderocol during successful treatment of carbapenem-resistant Acinetobacter baumannii meningitis.
J Antimicrob Chemother
; 77(10): 2737-2741, 2022 09 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35869778
4.
Pharmacokinetic/Pharmacodynamic Optimization of Hospital-Acquired and Ventilator-Associated Pneumonia: Challenges and Strategies.
Semin Respir Crit Care Med
; 43(2): 175-182, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35088402
5.
Phenazine Antibiotic-Inspired Discovery of Bacterial Biofilm-Eradicating Agents.
Chembiochem
; 20(23): 2885-2902, 2019 12 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30811834
6.
Transcript Profiling of MRSA Biofilms Treated with a Halogenated Phenazine Eradicating Agent: A Platform for Defining Cellular Targets and Pathways Critical to Biofilm Survival.
Angew Chem Int Ed Engl
; 57(47): 15523-15528, 2018 11 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30230671
7.
Identification of N-Arylated NH125 Analogues as Rapid Eradicating Agents against MRSA Persister Cells and Potent Biofilm Killers of Gram-Positive Pathogens.
Chembiochem
; 18(4): 352-357, 2017 02 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27925693
8.
Antimicrobial peptide-inspired NH125 analogues: bacterial and fungal biofilm-eradicating agents and rapid killers of MRSA persisters.
Org Biomol Chem
; 15(26): 5503-5512, 2017 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28534905
9.
Synthetically Tuning the 2-Position of Halogenated Quinolines: Optimizing Antibacterial and Biofilm Eradication Activities via Alkylation and Reductive Amination Pathways.
Chemistry
; 22(27): 9181-9, 2016 Jun 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-27245927
10.
Halogenated quinolines discovered through reductive amination with potent eradication activities against MRSA, MRSE and VRE biofilms.
Org Biomol Chem
; 13(41): 10290-4, 2015 Nov 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26414088
11.
Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures, and Mycobacterium tuberculosis.
Angew Chem Int Ed Engl
; 54(49): 14819-23, 2015 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26480852
12.
Discovery of quinoline small molecules with potent dispersal activity against methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a scaffold hopping strategy.
Bioorg Med Chem Lett
; 24(21): 5076-80, 2014 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25264073
13.
Physical compatibility of sulbactam/durlobactam with select intravenous drugs during simulated Y-site administration.
Am J Health Syst Pharm
; 81(1): e21-e29, 2024 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37740370
14.
Pharmacokinetic Analysis and In Vitro Synergy Evaluation of Cefiderocol, Sulbactam, and Tigecycline in an Extensively Drug-Resistant Acinetobacter baumannii Pneumonia Patient Receiving Continuous Venovenous Hemodiafiltration.
Open Forum Infect Dis
; 9(10): ofac484, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-36225744
15.
Transcript Profiling of Nitroxoline-Treated Biofilms Shows Rapid Up-regulation of Iron Acquisition Gene Clusters.
ACS Infect Dis
; 8(8): 1594-1605, 2022 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35830188
16.
A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents.
J Med Chem
; 64(11): 7275-7295, 2021 06 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33881312
17.
Rapid kill assessment of an N-arylated NH125 analogue against drug-resistant microorganisms.
Medchemcomm
; 10(5): 712-716, 2019 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31191861
18.
Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance.
J Med Chem
; 62(17): 7618-7642, 2019 09 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30951303
19.
Halogenated quinolines bearing polar functionality at the 2-position: Identification of new antibacterial agents with enhanced activity against Staphylococcus epidermidis.
Eur J Med Chem
; 155: 705-713, 2018 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29936357
20.
An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration.
J Med Chem
; 61(9): 3962-3983, 2018 05 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29638121