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1.
Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.
Bioorg Med Chem Lett
; 23(4): 996-1000, 2013 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23312944
2.
Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 21(12): 3715-20, 2011 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21571529
3.
Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-ß over Notch.
J Med Chem
; 56(13): 5261-74, 2013 Jul 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-23713656
4.
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Alzheimers Res Ther
; 2(6): 36, 2010 Dec 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-21190552
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