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1.
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human.
Xenobiotica
; 54(2): 64-74, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38197324
2.
Glycochenodeoxycholate and glycodeoxycholate 3-O-glucuronides, but not hexadecanedioate and tetradecanedioate, detected weak inhibition of OATP1B caused by GDC-0810 in humans.
Br J Clin Pharmacol
; 89(6): 1903-1907, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36735594
3.
Comprehensive Evaluation of Bile Acid Homeostasis in Human Hepatocyte Co-Culture in the Presence of Troglitazone, Pioglitazone, and Acetylsalicylic Acid.
Mol Pharm
; 16(10): 4230-4240, 2019 10 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31509422
4.
In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats.
Biopharm Drug Dispos
; 37(4): 200-11, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26637499
5.
High-throughput liquid chromatography/mass spectrometry method for the quantitation of small molecules using accurate mass technologies in supporting discovery drug screening.
Rapid Commun Mass Spectrom
; 27(3): 401-8, 2013 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23280971
6.
Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK).
Bioorg Med Chem Lett
; 23(23): 6331-5, 2013 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24138940
7.
IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans.
Microbiome
; 11(1): 47, 2023 03 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36894983
8.
Robust and Comprehensive Targeted Metabolomics Method for Quantification of 50 Different Primary, Secondary, and Sulfated Bile Acids in Multiple Biological Species (Human, Monkey, Rabbit, Dog, and Rat) and Matrices (Plasma and Urine) Using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS) Analysis.
J Am Soc Mass Spectrom
; 32(8): 2033-2049, 2021 Aug 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33826317
9.
A rapid derivatization based LC-MS/MS method for quantitation of short chain fatty acids in human plasma and urine.
Bioanalysis
; 11(8): 741-753, 2019 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-30993998
10.
Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State.
Cell Metab
; 28(3): 383-399.e9, 2018 09 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30043751
11.
NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus.
Nat Commun
; 9(1): 179, 2018 01 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29330524
12.
Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
Sci Signal
; 8(405): ra122, 2015 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26628680
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