Detalles de la búsqueda
1.
EZH2 inhibitor tazemetostat in patients with relapsed or refractory, BAP1-inactivated malignant pleural mesothelioma: a multicentre, open-label, phase 2 study.
Lancet Oncol
; 23(6): 758-767, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35588752
2.
Absorption, metabolism, and excretion of the antiemetic rolapitant, a selective neurokinin-1 receptor antagonist, in healthy male subjects.
Invest New Drugs
; 37(1): 139-146, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30032410
3.
Effects of rolapitant administered orally on the pharmacokinetics of dextromethorphan (CYP2D6), tolbutamide (CYP2C9), omeprazole (CYP2C19), efavirenz (CYP2B6), and repaglinide (CYP2C8) in healthy subjects.
Support Care Cancer
; 27(3): 819-827, 2019 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-30084103
4.
Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of cisplatin-based highly emetogenic chemotherapy in patients with cancer: two randomised, active-controlled, double-blind, phase 3 trials.
Lancet Oncol
; 16(9): 1079-1089, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-26272769
5.
Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut.
Cell Host Microbe
; 31(4): 634-649.e8, 2023 04 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37003258
6.
Population Pharmacokinetics of Rolapitant in Patients With Chemotherapy-Induced Nausea and Vomiting.
Clin Pharmacol Drug Dev
; 8(7): 850-860, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31418538
7.
A Phase 1 Assessment of the QT Interval in Healthy Adults Following Exposure to Rolapitant, a Cancer Supportive Care Antiemetic.
Clin Pharmacol Drug Dev
; 8(5): 603-611, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30256537
8.
Pharmacokinetics, Safety, and Tolerability of Rolapitant Administered Intravenously Following Single Ascending and Multiple Ascending Doses in Healthy Subjects.
Clin Pharmacol Drug Dev
; 8(2): 160-171, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29905976
9.
An Open-Label, Randomized, Pivotal Bioequivalence Study of Oral Rolapitant.
Clin Pharmacol Drug Dev
; 8(2): 152-159, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30624856
10.
Pharmacokinetics of Rolapitant in Patients With Mild to Moderate Hepatic Impairment.
J Clin Pharmacol
; 58(5): 686-693, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29329482
11.
Effects of Rolapitant Administered Intravenously or Orally on the Pharmacokinetics of Digoxin (P-glycoprotein Substrate) and Sulfasalazine (Breast Cancer Resistance Protein Substrate) in Healthy Volunteers.
J Clin Pharmacol
; 58(2): 202-211, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28906558
12.
The effect of food on the pharmacokinetics of niraparib, a poly(ADP-ribose) polymerase (PARP) inhibitor, in patients with recurrent ovarian cancer.
Cancer Chemother Pharmacol
; 81(3): 497-503, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29322231
13.
Effects of Rolapitant Administered Intravenously on the Pharmacokinetics of a Modified Cooperstown Cocktail (Midazolam, Omeprazole, Warfarin, Caffeine, and Dextromethorphan) in Healthy Subjects.
J Clin Pharmacol
; 58(8): 1074-1083, 2018 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-29693712
14.
Bioequivalence of Intravenous and Oral Rolapitant: Results From a Randomized, Open-Label Pivotal Study.
J Clin Pharmacol
; 57(12): 1600-1606, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28906561
15.
Derivation of Phase 3 dosing for peginterferon lambda-1a in chronic hepatitis C, Part 2: Exposure-response analyses for efficacy and safety variables.
J Clin Pharmacol
; 55(1): 73-80, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25042797
16.
Derivation of Phase 3 dosing for peginterferon lambda-1a in chronic hepatitis C, Part 1: Modeling optimal treatment duration and sustained virologic response rates.
J Clin Pharmacol
; 55(1): 63-72, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25043197
17.
A randomized, double-blind, placebo-controlled assessment of BMS-936558, a fully human monoclonal antibody to programmed death-1 (PD-1), in patients with chronic hepatitis C virus infection.
PLoS One
; 8(5): e63818, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23717490
18.
Adenosine A2A and beta-2 adrenergic receptor agonists: novel selective and synergistic multiple myeloma targets discovered through systematic combination screening.
Mol Cancer Ther
; 11(7): 1432-42, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22474168
19.
Development and validation of a liquid chromatography-tandem mass spectrometry assay for the simultaneous quantitation of prednisolone and dipyridamole in human plasma and its application in a pharmacokinetic study.
J Pharm Biomed Anal
; 49(5): 1241-9, 2009 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-19304431
20.
Biotransformation and in vitro assessment of metabolism-associated drug-drug interaction for CRx-102, a novel combination drug candidate.
J Pharm Biomed Anal
; 50(2): 200-9, 2009 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-19467820