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1.
Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11ß-HSD1 using a scaffold-hopping approach.
Bioorg Med Chem Lett
; 69: 128782, 2022 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35537608
2.
Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy.
J Pharmacol Exp Ther
; 374(1): 211-222, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32345620
3.
INCB040093 Is a Novel PI3Kδ Inhibitor for the Treatment of B Cell Lymphoid Malignancies.
J Pharmacol Exp Ther
; 364(1): 120-130, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29127109
4.
Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3.
J Med Chem
; 65(22): 15433-15442, 2022 11 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36356320
5.
A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity.
Front Oncol
; 10: 598477, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-33425754
6.
Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition.
Bioorg Med Chem Lett
; 19(13): 3525-30, 2009 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19457660
7.
INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3Kδ).
ACS Med Chem Lett
; 10(11): 1554-1560, 2019 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31749910
8.
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
J Med Chem
; 50(4): 603-6, 2007 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17256836
9.
Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.
Cancer Biol Ther
; 5(6): 657-64, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16627989
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