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1.

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine.

Briggs, Kimberly J; Koivunen, Peppi; Cao, Shugeng; Backus, Keriann M; Olenchock, Benjamin A; Patel, Hetalben; Zhang, Qing; Signoretti, Sabina; Gerfen, Gary J; Richardson, Andrea L; Witkiewicz, Agnieszka K; Cravatt, Benjamin F; Clardy, Jon; Kaelin, William G.

Cell ; 166(1): 126-39, 2016 Jun 30.

Artículo en Inglés | MEDLINE | ID: mdl-27368101

2.

Activation of the hypoxia-inducible factor pathway by roxadustat improves glucose metabolism in human primary myotubes from men.

Mäkinen, Selina; Sree, Sreesha; Ala-Nisula, Tuulia; Kultalahti, Henric; Koivunen, Peppi; Koistinen, Heikki A.

Diabetologia ; 2024 May 30.

Artículo en Inglés | MEDLINE | ID: mdl-38814443

3.

Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice.

Ala-Nisula, Tuulia; Halmetoja, Riikka; Leinonen, Henri; Kurkela, Margareta; Lipponen, Henna-Riikka; Sakko, Samuli; Karpale, Mikko; Salo, Antti M; Sissala, Niina; Röning, Tapio; Raza, Ghulam S; Mäkelä, Kari A; Thevenot, Jérôme; Herzig, Karl-Heinz; Serpi, Raisa; Myllyharju, Johanna; Tanila, Heikki; Koivunen, Peppi; Dimova, Elitsa Y.

Pflugers Arch ; 2024 Feb 24.

Artículo en Inglés | MEDLINE | ID: mdl-38396259

4.

Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism.

Tapio, Joona; Halmetoja, Riikka; Dimova, Elitsa Y; Mäki, Joni M; Laitala, Anu; Walkinshaw, Gail; Myllyharju, Johanna; Serpi, Raisa; Koivunen, Peppi.

J Biol Chem ; 298(8): 102222, 2022 08.

Artículo en Inglés | MEDLINE | ID: mdl-35787374

5.

Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation.

Byts, Nadiya; Sharma, Subodh; Malm, Tarja; Kaakinen, Mika; Korhonen, Paula; Jaakkonen, Laura; Keuters, Meike; Huuskonen, Mikko; Pietilä, Ilkka; Koistinaho, Jari; Koivunen, Peppi; Myllyharju, Johanna.

J Biol Chem ; 298(3): 101721, 2022 03.

Artículo en Inglés | MEDLINE | ID: mdl-35151685

6.

Lower hemoglobin levels associate with higher baroreflex sensitivity and heart rate variability.

Tapio, Joona; Kiviniemi, Antti M; Perkiömäki, Juha; Junttila, M Juhani; Huikuri, Heikki V; Ukkola, Olavi; Koivunen, Peppi; Tulppo, Mikko P.

Am J Physiol Heart Circ Physiol ; 325(4): H629-H634, 2023 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-37566112

7.

Characterization of genetic variants in the EGLN1/PHD2 gene identified in a European collection of patients with erythrocytosis.

Delamare, Marine; Le Roy, Amandine; Pacault, Mathilde; Schmitt, Loïc; Garrec, Céline; Maaziz, Nada; Myllykoski, Matti; Rimbert, Antoine; Karaghiannis, Valéna; Aral, Bernard; Catherwood, Mark; Airaud, Fabrice; Mansour-Hendili, Lamisse; Hoogewijs, David; Peroni, Edoardo; Idriss, Salam; Lesieur, Valentine; Caillaud, Amandine; Si-Tayeb, Karim; Chariau, Caroline; Gaignerie, Anne; Rab, Minke; Haferlach, Torsten; Meggendorfer, Manja; Bézieau, Stéphane; Benetti, Andrea; Casadevall, Nicole; Hirsch, Pierre; Rose, Christian; Wemeau, Mathieu; Galacteros, Frédéric; Cassinat, Bruno; Bellosillo, Beatriz; Bento, Celeste; Van Wijk, Richard; Petrides, Petro E; Randi, Maria Luigia; McMullin, Mary Frances; Koivunen, Peppi; Girodon, François; Gardie, Betty.

Haematologica ; 108(11): 3068-3085, 2023 11 01.

Artículo en Inglés | MEDLINE | ID: mdl-37317877

8.

Remote ischemic preconditioning and hypoxia-induced biomarkers in acute myocardial infarction: study on a porcine model.

Anttila, Tuomas; Herajärvi, Johanna; Laaksonen, Henna; Mustonen, Caius; Honkanen, Hannu-Pekka; Y Dimova, Elitsa; Piuhola, Jarkko; Koivunen, Peppi; Juvonen, Tatu; Anttila, Vesa.

Scand Cardiovasc J ; 57(1): 2251730, 2023 12.

Artículo en Inglés | MEDLINE | ID: mdl-37641930

9.

Activation of the hypoxia response protects mice from amyloid-ß accumulation.

Ollonen, Teemu; Kurkela, Margareta; Laitakari, Anna; Sakko, Samuli; Koivisto, Henna; Myllyharju, Johanna; Tanila, Heikki; Serpi, Raisa; Koivunen, Peppi.

Cell Mol Life Sci ; 79(8): 432, 2022 Jul 19.

Artículo en Inglés | MEDLINE | ID: mdl-35852609

10.

Activation of the hypoxia response pathway protects against age-induced cardiac hypertrophy.

Röning, Tapio; Magga, Johanna; Laitakari, Anna; Halmetoja, Riikka; Tapio, Joona; Dimova, Elitsa Y; Szabo, Zoltan; Rahtu-Korpela, Lea; Kemppi, Anna; Walkinshaw, Gail; Myllyharju, Johanna; Kerkelä, Risto; Koivunen, Peppi; Serpi, Raisa.

J Mol Cell Cardiol ; 164: 148-155, 2022 03.

Artículo en Inglés | MEDLINE | ID: mdl-34919895

11.

Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains.

Myllykoski, Matti; Sutinen, Aleksi; Koski, M Kristian; Kallio, Juha P; Raasakka, Arne; Myllyharju, Johanna; Wierenga, Rik K; Koivunen, Peppi.

J Biol Chem ; 296: 100197, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-33334883

12.

HIDEA syndrome is caused by biallelic, pathogenic, rare or founder P4HTM variants impacting the active site or the overall stability of the P4H-TM protein.

Kraatari-Tiri, Minna; Soikkonen, Leila; Myllykoski, Matti; Jamshidi, Yalda; Karimiani, Ehsan G; Komulainen-Ebrahim, Jonna; Kallankari, Hanna; Mignot, Cyril; Depienne, Christel; Keren, Boris; Nougues, Marie-Christine; Alsahlawi, Zahra; Romito, Antonio; Martini, Javier; Toosi, Mehran B; Carroll, Christopher J; Tripolszki, Kornelia; Bauer, Peter; Uusimaa, Johanna; Bertoli-Avella, Aida M; Koivunen, Peppi; Rahikkala, Elisa.

Clin Genet ; 102(5): 444-450, 2022 11.

Artículo en Inglés | MEDLINE | ID: mdl-35908151

13.

Genetic Ablation of Transmembrane Prolyl 4-Hydroxylase Reduces Atherosclerotic Plaques in Mice.

Määttä, Jenni; Serpi, Raisa; Hörkkö, Sohvi; Izzi, Valerio; Myllyharju, Johanna; Dimova, Elitsa Y; Koivunen, Peppi.

Arterioscler Thromb Vasc Biol ; 41(7): 2128-2140, 2021 07.

Artículo en Inglés | MEDLINE | ID: mdl-34039020

14.

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.

Zheng, Xingnan; Zhai, Bo; Koivunen, Peppi; Shin, Sandra J; Lu, Gang; Liu, Jiayun; Geisen, Christoph; Chakraborty, Abhishek A; Moslehi, Javid J; Smalley, David M; Wei, Xin; Chen, Xian; Chen, Zhengming; Beres, Justine M; Zhang, Jing; Tsao, Jen Lan; Brenner, Mitchell C; Zhang, Yuqing; Fan, Cheng; DePinho, Ronald A; Paik, Jihye; Gygi, Steven P; Kaelin, William G; Zhang, Qing.

Genes Dev ; 28(13): 1429-44, 2014 Jul 01.

Artículo en Inglés | MEDLINE | ID: mdl-24990963

15.

Systemic long-term inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 ameliorates aging-induced changes in mice without affecting their life span.

Laitakari, Anna; Huttunen, Riikka; Kuvaja, Paula; Hannuksela, Pauliina; Szabo, Zoltan; Heikkilä, Minna; Kerkelä, Risto; Myllyharju, Johanna; Dimova, Elitsa Y; Serpi, Raisa; Koivunen, Peppi.

FASEB J ; 34(4): 5590-5609, 2020 04.

Artículo en Inglés | MEDLINE | ID: mdl-32100354

16.

Expression and Roles of Individual HIF Prolyl 4-Hydroxylase Isoenzymes in the Regulation of the Hypoxia Response Pathway along the Murine Gastrointestinal Epithelium.

Dengler, Franziska; Sova, Sofia; Salo, Antti M; Mäki, Joni M; Koivunen, Peppi; Myllyharju, Johanna.

Int J Mol Sci ; 22(8)2021 Apr 14.

Artículo en Inglés | MEDLINE | ID: mdl-33919829

17.

Biallelic loss-of-function P4HTM gene variants cause hypotonia, hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye abnormalities (HIDEA syndrome).

Rahikkala, Elisa; Myllykoski, Matti; Hinttala, Reetta; Vieira, Päivi; Nayebzadeh, Naemeh; Weiss, Simone; Plomp, Astrid S; Bittner, Reginald E; Kurki, Mitja I; Kuismin, Outi; Lewis, Andrea M; Väisänen, Marja-Leena; Kokkonen, Hannaleena; Westermann, Jonne; Bernert, Günther; Tuominen, Hannu; Palotie, Aarno; Aaltonen, Lauri; Yang, Yaping; Potocki, Lorraine; Moilanen, Jukka; van Koningsbruggen, Silvana; Wang, Xia; Schmidt, Wolfgang M; Koivunen, Peppi; Uusimaa, Johanna.

Genet Med ; 21(10): 2355-2363, 2019 10.

Artículo en Inglés | MEDLINE | ID: mdl-30940925

18.

The TET enzymes.

Koivunen, Peppi; Laukka, Tuomas.

Cell Mol Life Sci ; 75(8): 1339-1348, 2018 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-29184981

19.

Lack of P4H-TM in mice results in age-related retinal and renal alterations.

Leinonen, Henri; Rossi, Maarit; Salo, Antti M; Tiainen, Päivi; Hyvärinen, Jaana; Pitkänen, Marja; Sormunen, Raija; Miinalainen, Ilkka; Zhang, Chi; Soininen, Raija; Kivirikko, Kari I; Koskelainen, Ari; Tanila, Heikki; Myllyharju, Johanna; Koivunen, Peppi.

Hum Mol Genet ; 25(17): 3810-3823, 2016 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-27466183

20.

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

Koivunen, Peppi; Lee, Sungwoo; Duncan, Christopher G; Lopez, Giselle; Lu, Gang; Ramkissoon, Shakti; Losman, Julie A; Joensuu, Päivi; Bergmann, Ulrich; Gross, Stefan; Travins, Jeremy; Weiss, Samuel; Looper, Ryan; Ligon, Keith L; Verhaak, Roel G W; Yan, Hai; Kaelin, William G.

Nature ; 483(7390): 484-8, 2012 Feb 15.

Artículo en Inglés | MEDLINE | ID: mdl-22343896

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